Maleimide–thiol adducts stabilized through stretching

Maleimide–thiol adducts stabilized through stretching

Maleimide–thiol adducts stabilized through stretching, Published online: 04 February 2019; doi:10.1038/s41557-018-0209-2

Single-molecule force spectroscopy reveals that maleimide–thiol adducts can be stabilized by stretching through a force-dependent kinetic control mechanism. This unconventional use of mechanochemistry enabled us to produce stable polymer–protein conjugates by simply applying a mechanical force to the maleimide–thiol adducts through mild ultrasonication.

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