Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study

alexandrossfakianakis shared this article with you from Inoreader Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study via International Journal of Epidemiology - Advance Access Abstract Background Low vitamin D status is often associated with systemic low-grade inflammation as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and direction of the association between vitamin D status and CRP using linear and non-linear Mendelian randomization (MR) analyses. Methods MR analyses were conducted using data from 294 970 unrelated participants of White-British ancestry from the UK Biobank. Serum 25-hydroxyvitamin D [25(OH)D] and CRP concentrations were instrumented using 35 and 46 genome-wide significant variants, respectively. Results In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ∼50 nmol/L of 25(OH)D (Pnon-linear� ��= 1.49E-4). Analyses using several pleiotropy-robust methods provided consistent results in stratified MR analyses, confirming the inverse association between 25(OH)D and CRP in the deficiency range (P = 1.10E-05) but not with higher concentrations. Neither linear or non-linear MR analysis supported a causal effect of serum CRP level on 25(OH)D concentration (Plinear = 0.32 and Pnon-linear = 0.76). Conclusion The observed association between 25(OH)D and CRP is likely to be caused by vitamin D deficiency. Correction of low vitamin D status may reduce chronic inflammation. View on Web

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p53 missense mutant G242A subverts natural killer cells in sheltering mouse breast cancer cells against immune rejection

alexandrossfakianakis shared this article with you from Inoreader p53 missense mutant G242A subverts natural killer cells in sheltering mouse breast cancer cells against immune rejection via ScienceDirect Publication: Experimental Cell Research Publication date: Available online 18 May 2022 Source: Experimental Cell Research Author(s): Mohammad B. Uddin, Kartik R. Roy, Ronald A. Hill, Sagor C. Roy, Xin Gu, Li Li, Qian-Jin Zhang, Zongbing You, Yong-Yu Liu View on Web

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Endoscopic modified transseptal bi-nostril approach for pituitary tumors. Efficacy of complex preservation of every turbinate and olfaction: A STROBE analysis

alexandrossfakianakis shared this article with you from Inoreader Endoscopic modified transseptal bi-nostril approach for pituitary tumors. Efficacy of complex preservation of every turbinate and olfaction: A STROBE analysis via ScienceDirect Publication: European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 18 May 2022 Source: European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): T. Takeda, K. Omura, E. Mori, R. Mori, Y. Ishii, N. Otori View on Web

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High dose chemoradiotherapy increases chance of organ preservation with satisfactory functional outcome for rectal cancer

alexandrossfakianakis shared this article with you from Inoreader High dose chemoradiotherapy increases chance of organ preservation with satisfactory functional outcome for rectal cancer via Radiation Oncology - Latest Articles High dose chemoradiotherapy offers a curative chance for patients with rectal cancer that are unfit or unwilling to undergo surgical resection, yet its long-term survival and functional outcomes have been rare... View on Web

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Transcranial electric and acoustic stimulation for tinnitus: study protocol for a randomized double-blind controlled trial assessing the influence of combined transcranial random noise and acoustic stimulation on tinnitus loudness and distress

alexandrossfakianakis shared this article with you from Inoreader Transcranial electric and acoustic stimulation for tinnitus: study protocol for a randomized double-blind controlled trial assessing the influence of combined transcranial random noise and acoustic stimulation on tinnitus loudness and distress via Trials - Latest Articles Tinnitus is the result of aberrant neuronal activity. As a novel treatment form, neuromodulation is used to modify neuronal activity of brain areas involved in tinnitus generation. Among the different forms of... View on Web

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PD-L1 expression in 117 sinonasal mucosal melanomas and its association with clinical outcome

alexandrossfakianakis shared this article with you from Inoreader PD-L1 expression in 117 sinonasal mucosal melanomas and its association with clinical outcome via Annals of Diagnostic Pathology Publication date: Available online 18 May 2022 Source: Annals of Diagnostic Pathology Author(s): Lining Wang, Honggang Liu View on Web

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‘T4b’ or not to ‘T4b’: addressing the resectability in T4b oral cavity squamous cell carcinoma

alexandrossfakianakis shared this article with you from Inoreader 'T4b' or not to 'T4b': addressing the resectability in T4b oral cavity squamous cell carcinoma via International Journal of Oral and Maxillofacial Surgery via MedWorm.com The treatment and management of patients with T4b oral cavity squamous cell carcinoma (OCSCC) has always been a strong topic of discussion and we commend the efforts made by Kumar et al.1 in their study assessing the role of the structures involved in T4b OCSCC. The authors performed a retrospective analysis of T4 OCSCC treated with surgery and the structures involved, and a comparative survival analysis was done. We are thankful to the authors for sharing their results, which may have therapeutic implications in addressing the surgical resection of T4b OCSCC. (Source: International Journal of Oral and Maxillofacial Surgery) View on Web

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Infrahyoid myocutaneous flap in head and neck reconstruction: a systematic review and meta-analysis

alexandrossfakianakis shared this article with you from Inoreader Infrahyoid myocutaneous flap in head and neck reconstruction: a systematic review and meta-analysis via International Journal of Oral and Maxillofacial Surgery via MedWorm.com The aim of this systematic review and meta-analysis was to analyse the literature on the infrahyoid myocutaneous flap (IHMCF) and evaluate its clinical outcomes. The MEDLINE, Embase, Web of Science, Cochrane Library, and Scopus databases were searched (inception to December 31, 2021). Meta-analyses were then conducted to estimate the overall rates of partial flap loss, total flap loss, salivary fistula, and surgical revision. The 21 studies that met the inclusion criteria included 768 patients undergoing head and neck reconstruction with 773 IHMCF. (Source: International Journal of Oral and Maxillofacial Surgery) View on Web

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Posterior tibial artery flap versus radial forearm flap in oral cavity reconstruction and donor site morbidity

alexandrossfakianakis shared this article with you from Inoreader Posterior tibial artery flap versus radial forearm flap in oral cavity reconstruction and donor site morbidity via International Journal of Oral and Maxillofacial Surgery via MedWorm.com The repair of soft tissue defects after oral cavity cancer resection is challenging. The aim of this study was to compare the outcomes and donor site morbidity of the radial forearm free flap (RFF) and posterior tibial artery perforator flap (PTAF) for oral cavity reconstruction after cancer ablation. All patients who underwent oral cavity reconstruction with a RFF or PTAF between January 2017 and December 2019 were included retrospectively in this study. All flaps were harvested with a long adipofascial extension. (Source: International Journal of Oral and Maxillofacial Surgery) View on Web

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