Thursday, February 14, 2019

A Tumor-targeting Ru/Polysaccharide/Protein Supramolecular Assembly with High Photodynamic Therapy Ability

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C8CC09964B, Communication
Hongguang Fu, Yong Chen, Qilin Yu, Yu Liu
Supramolecular assembly with tumor-targeting property or photodynamic therapy (PDT) ability has recently become a focus of interest in biomaterial fields because of their high therapeutic efficacy against tumor cells. Herein,...
The content of this RSS Feed (c) The Royal Society of Chemistry


from Journals via hj on Inoreader https://rsc.li/2tmoTLh

Tips for psychologists on how to spread climate propaganda from Down Under

What-we-do-ClimateChange-Communication-5

From the Australian Psychological Society. Climate change communication Such gems as: Communicating effectively about a topic like climate change that is complex, confusing, uncertain, sometimes overwhelming, and often emotionally and politically loaded, is challenging. In order for people to become motivated and empowered to adopt the needed changes to reduce environmental threats, they must be…

from Climate Change Skeptic Blogs via hj on Inoreader http://bit.ly/2SD1OTU

The Marvelous and Mysterious Monarch

marvelous_monarchs-featured-1.jpg?is-pen

Guest essay by Kip Hansen   The marvelous Monarch Butterfly is an icon of biological mystery.  When I was born, circa 1950, monarchs were known to fly north into southern Texas every spring by the millions.  In the Fall, tourists would go to Cape May, New Jersey, timing their visits to watch the beauty and…

from Climate Change Skeptic Blogs via hj on Inoreader http://bit.ly/2DQfLnl

Low-toxicity Amphiphilic Molecules linked by an Aromatic Nucleus Show Broad-spectrum Antibacterial Activity and Low Drug Resistance

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C9CC00857H, Communication
Chu Wenchao, Yi Yang, Shangshang Qin, Jianfeng Cai, Mengmeng Bai, kong hongtao, En Zhang
Amphiphilic molecules linked by an aromatic nucleus were developed that showed high selectivity toward bacteria over mammalian cells, and low drug resistance. Promising compound 4g exhibited strong bactericidal activity against...
The content of this RSS Feed (c) The Royal Society of Chemistry


from Journals via hj on Inoreader https://rsc.li/2SSiYMu

Phosphine-Catalysed Asymmetric Dearomative Formal [4 + 2] Cycloadditions of 3-Benzofuranyl Vinyl Ketones

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C9CC00386J, Communication
Ben-Xian Xiao, Bo Jiang, Xue Song, Wei Du, Ying-Chun Chen
In contrast to the catalytic asymmetric dearomative reactions of indole substrates, the analogous benzofuran derivatives have been less explored. Here we report that the stereoselective domino Rauhut-Currier/Michael addition process of...
The content of this RSS Feed (c) The Royal Society of Chemistry


from Journals via hj on Inoreader https://rsc.li/2SXmXHw

High Selective Imaging of Lysosomal Azoreductase under Hypoxia Using pH-Regulated and Target-Activated Fluorescent Nanoprobes

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C9CC00462A, Communication
Cong Zhu, zhen zou, Caixia Huang, Jing Zheng, Na Liu, Jishan Li, Rong-Hua Yang
In this work, we propose a pH-regulated and target-activated fluorescent nanoprobe for high selective monitoring lysosomal azoreductase under hypoxia in living cells. We expect it will offer a potentially rich...
The content of this RSS Feed (c) The Royal Society of Chemistry


from Journals via hj on Inoreader https://rsc.li/2N5uZsN

Polymorphism in M(H2PO2)3 (M = V, Al, Ga) compounds with the perovskite-related ReO3 structure.

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C9CC00118B, Communication
Hayden Evans, Zeyu Deng, Ines Collings, Yue Wu, Jessica L. Andrews, Kartik Pilar, Joshua Mark Tuffnell, Guang Wu, John Wang, S E E Dutton, Paul Bristowe, Ram Seshadri, Anthony K. Cheetham
Trivalent metal hypophosphites with the general formula M(H2PO2)3 (M = V, Al, Ga) adopt the ReO3 structure, with each compound displaying two structural polymorphs. High-pressure synchrotron X-ray studies reveal a...
The content of this RSS Feed (c) The Royal Society of Chemistry


from Journals via hj on Inoreader https://rsc.li/2N6cyE3

[ASAP] Direct Quantification of Rapid and Efficient Single-Stroke Actuation by a Martensitic Transition in a Thermosalient Crystal

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b12752
jacsat?d=yIl2AUoC8zA


from Journals via hj on Inoreader http://bit.ly/2TVSPdb

[ASAP] A Plasmon-Mediated Electron Emission Process

TOC Graphic

ACS Nano
DOI: 10.1021/acsnano.8b08444
ancac3?d=yIl2AUoC8zA


from Journals via hj on Inoreader http://bit.ly/2IgpMzr

[ASAP] P–N Junction Diode Using Plasma Boron-Doped Black Phosphorus for High-Performance Photovoltaic Devices

TOC Graphic

ACS Nano
DOI: 10.1021/acsnano.8b07730
ancac3?d=yIl2AUoC8zA


from Journals via hj on Inoreader http://bit.ly/2TRrgSe

[ASAP] Template-Free Construction of Highly Ordered Monolayered Fluorescent Protein Nanosheets: A Bioinspired Artificial Light-Harvesting System

TOC Graphic

ACS Nano
DOI: 10.1021/acsnano.8b08021
ancac3?d=yIl2AUoC8zA


from Journals via hj on Inoreader http://bit.ly/2BBKdRv

[ASAP] Exploring the Heterogeneity of Nanoparticles in Their Interactions with Plasma Coagulation Factor XII

TOC Graphic

ACS Nano
DOI: 10.1021/acsnano.8b08471
ancac3?d=yIl2AUoC8zA


from Journals via hj on Inoreader http://bit.ly/2TSl1gQ

Organo-modification of montmorillonite for enhancing the adsorption efficiency of cobalt radionuclides from aqueous solutions

Abstract

Montmorillonite clay was organically modified with thoron (TH) and was employed as an adsorbent for removal of cobalt(II) radionuclides from aqueous solutions. Batch adsorption experiments, under several operational parameters such as pH, contact time, initial adsorbate concentration, adsorbent dosage, ionic strength, and temperature, were conducted to determine the optimum conditions for efficient removal of cobalt(II) radionuclides. The obtained data showed that almost complete removals were achieved for cobalt(II) at pH values ≥ 3.5 using TH-modified montmorillonite (TMM), while only 63% were obtained by unmodified clay at pH ≥ 5.4. Adsorption kinetic data of cobalt(II) were better fitted by the pseudo-second order kinetic model and its adsorption rate was controlled by film diffusion. Both Langmuir and Freundlich models had the ability to well describe the equilibrium data of cobalt(II) radionuclides at the studied temperatures. The adsorption capacity of TMM (0.85 mmol/g) was found to be not only nine times that of unmodified montmorillonite (0.097 mmol/g), but also higher than those reported in literature using various unmodified and modified clays. Thermodynamic parameters (ΔH°, ΔS°, and ΔG°) were calculated. Among the examined desorbing agents, both Al3+ and EDTA were succeeded to desorb most of cobalt(II) radionuclides (desorption % ~ 90%) loaded onto TMM. The results of this study clarified that TMM can be considered as an effective adsorbent for removal of cobalt(II) radionuclides from aqueous solutions.



from Climate Change Skeptic Blogs via hj on Inoreader http://bit.ly/2tr3IYt

DC District Court Hands Trump’s EPA A Major Victory Over Environmentalists

RTX6AF0M.jpg?is-pending-load=1

From The Daily Caller Michael Bastasch | Energy Editor The District of Columbia District Court granted the Environmental Protection Agency's (EPA) petition to dismiss legal action against a policy to prohibit scientists from receiving agency funding while sitting on advisory boards. EPA issued the policy directive in 2017 under former Administrator Scott Pruitt. A coalition…

from Climate Change Skeptic Blogs via hj on Inoreader http://bit.ly/2S3BFse

Polar bears walking the streets on Novaya Zemlya are habituated garbage bears, not victims of climate change

What a bunch of sensationalist claptrap about the polar bears on Novaya Zemlya but I guess it sells papers and raises donations (WWF and PBI, I mean you).1

Nilsen_when the internet came to Novaya Zemlya_cites my blog post_14 Feb 2019

Seriously, if the bears were coming for us, people in Belushaya Guba would have died already, probably EATEN. These particular bears know there is stored food and refuse available that does not come packaged in human form and they know from experience that humans won't hurt them. As I pointed out in my last post, these bears have known this since early December, when they chose to stay on land over the winter and ignored the sea ice when it arrived.

Lack of sea ice is not the problem here. These are habituated garbage bears that are no longer safe to have around: the responsible option is to shoot them. It's harsh, I know, but the population will recover from the loss.

Belushaya Guba garbage dump_Daily Mail_11 Feb 2019

If you suddenly cut off their passive food supply (fence or close the dump, deal more carefully with individual refuse and stored food), all of these bears in the photos and videos being flashed across the Internet will become desperate and truly dangerous. Remember, just last summer an emaciated, desperate bear almost killed a cruise ship guard: he had a loaded gun and was actively looking for bears, yet the bear managed to ambush him. He'd have died if he'd been alone.

Of course the refuse and stored food problem needs to be dealt with, in Belushaya Guba and elsewhere across the Arctic, but these particular bears cannot be saved. Cleaning up these issues takes time, coordination, and money. Ask Churchill, Manitoba, who for years wrestled with these issues before a workable solution was agreed upon. And while few Arctic communities can afford to do it the Churchill way, virtually all must contend with the very real threat of polar bears both inside and outside their communities. Ask the Inuit of Arviat and Naujaat, who each lost a young man last summer to a predatory attack by a polar bear that happened well outside their respective villages and where lack of sea ice was not an issue.

Blaming this on climate change is the Paul Nicklen starving polar bear video all over again. You remember the one, the video that National Geographic got so much push-back about that they had to make a public apology for spreading misinformation?

Do climate change promoters really need another fiasco featuring polar bears?

Are they really thinking this incident will somehow be 'the one' that will convince the public that climate change should be a priority for them? They clearly do not understand that this is the same 'public' who have seen black bears and/or grizzlies at town dumps, and know that scavenging is a common behaviour of all bears. The public who probably have experience with what happens when you clean up community garbage tissues without destroying the particular bears who are habituated to it – they start attacking people. The public who knows that relocating habituated bears doesn't work – they always find their way back, either to the dump they know or another one. Google 'dump bears.'

Still no further word from Russia on this incident, everyone is still rehashing the original report: there has been ice right off Belushaya Guba since 11 February. But I'm guessing the bears won't be leaving of their own accord (see previous post for location of Belushaya Guba and other sea ice charts).

Barents Sea ice extent 2019 Feb 11_NIS

Footnote 1. Yes, WWF has assisted some communities protect themselves against polar bears but their role is primarily educational. In Arviat in 2014, WWF funded the cost of one paid community patrol guard, out of the four deemed necessary (pdf here). WWF likes to pat itself on the back for its work on this problem but while its better than nothing, the costs involved in securely storing food and garbage, as well as hiring patrol personnel, are probably the biggest hold-up for most communities. WWF brings in tens of millions every year but spends a pitance on keeping Arctic residents safe from polar bears.



from Climate Change Skeptic Blogs via hj on Inoreader http://bit.ly/2SWXazc

Latest Fake Claims About Greenland Ice Loss; and Polar Bears

--------

It's worse than we thought, says the Guardian:

image
Enlarged

Greenland is melting faster than scientists previously thought, with the pace of ice loss increasing four-fold since 2003, new research has found.

Enormous glaciers in Greenland are depositing ever larger chunks of ice into the Atlantic ocean, where it melts. But scientists have found that the largest ice loss in the decade from 2003 actually occurred in the southwest region of the island, which is largely glacier-free.

This suggests surface ice is simply melting as global temperatures rise, causing gushing rivers of meltwater to flow into the ocean and push up sea levels. South-west Greenland, not previously thought of as a source of woe for coastal cities, is set to "become a major future contributor to sea level rise" the research states.

"We knew we had one big problem with increasing rates of ice discharge by some large outlet glaciers," said Michael Bevis, lead author of the paper (no doubt with Butthead) and a professor of geodynamics at Ohio State University. "But now we recognize a second serious problem: increasingly, large amounts of ice mass are going to leave as meltwater, as rivers that flow into the sea.

The research provides fresh evidence of the dangers posed to vulnerable coastal places as diverse as Miami, Shanghai, Bangladesh and various Pacific islands as climate change shrinks the world's land-based ice.

"The only thing we can do is adapt and mitigate further global warming - it's too late for there to be no effect," Bevis said. "This is going to cause additional sea level rise. We are watching the ice sheet hit a tipping point.

"We're going to see faster and faster sea level rise for the foreseeable future. Once you hit that tipping point, the only question is: How severe does it get?"

The study, published in Proceedings of the National Academy of Sciences, used data from NASA's gravity recovery and climate experiment (known as Grace) and GPS stations scattered across Greenland to analyze changes in ice mass.

This showed that Greenland lost around 280bn tons of ice per year between 2002 and 2016, enough to raise the worldwide sea level by 0.03 inches annually. If all of Greenland's vast ice sheet, 3km thick in places, was to melt, global sea levels would rise by seven meters, or more than 20ft, drowning most coastal settlements.

image
Enlarged

When the long term numbers are not scary enough, concentrate on one year's weather instead!

I will explain.

Science Daily has more detail on the Bevis paper here. For some reason, it does not appear on the PNAS site yet.

Science Daily elaborate on the "faster than 2003" claim:

Bevis' team used data from GRACE and from GPS stations scattered around Greenland's coast to identify changes in ice mass. The patterns they found show an alarming trend - by 2012, ice was being lost at nearly four times the rate that prevailed in 2003.

Bevis said a natural weather phenomenon - the North Atlantic Oscillation, which brings warmer air to West Greenland, as well as clearer skies and more solar radiation - was building on man-made climate change to cause unprecedented levels of melting and runoff. Global atmospheric warming enhances summertime melting, especially in the southwest. The North Atlantic Oscillation is a natural - if erratic - cycle that causes ice to melt under normal circumstances. When combined with man-made global warming, though, the effects are supercharged.

"These oscillations have been happening forever," Bevis said. "So why only now are they causing this massive melt? It's because the atmosphere is, at its baseline, warmer. The transient warming driven by the North Atlantic Oscillation was riding on top of more sustained, global warming."

But what happened in 2012?

Due to that weather event, the NAO, Greenland experienced an unusually mild year, with in particular a sunny summer.

Bevis asks:

"These oscillations have been happening forever. So why only now are they causing this massive melt? "

Because we have only been monitoring the melt for the last decade or two!

We know that global sea level rise was just as great in the early to mid 20th century, and there is therefore no evidence whatsoever that melting of the Greenland ice sheet was not just as great back then.

image
Enlarged

Unsurprisingly, therefore, the Surface Mass Balance of the Greenland ice sheet shrank slightly, due to both reduced snowfall and ice melt:

image
Enlarged

image
Enlarged

However, that was the exception. Last year, for instance, the SMB grew much more than the long term mean, as it did the year before.

Bevis' claim that ice loss in 2012 was greater than in 2003 is based on one year's weather, and not the long term trend.

It is worth emphasizing here that the SMB reflects both snowfall and ice melt, but not calving of glaciers. It is, of course, ice melt that Bevis is mainly concerned about here.

As we can see from the above temperature chart for SW Greenland, with the exception of 2012, temperatures since 2003 are little different to the 1920s to 40s, the last time the AMO was in warm phase, as it presently is.

There is simply no evidence at all of Greenland's climate getting any warmer over the long term.

As for the lurid threats of multi meter sea level rise, according to DMI loss of ice from the Greenland ice sheet (from all causes) since 2003 has accounted for about 0.65mm a year of global sea level rise, little more than 2 inches per century.

------------

Media Ignore Inconvenient Truths When Pushing Polar Bear Invasion Stories

This story could very well be headlined: "When the internet came to Novaya Zemlya."

Locals started to post photos and video of the more than 50 polar bears in their neighborhood.

Over the last week, social media, as well as online newspapers globally, have gone mad over the news coming out from one of the remotest towns on the planet, the closed military settlement of Belushaya Guba.

The little-known town on the Russian Arctic archipelago has since last autumn been struggling with polar bears walking the streets and around the corners of the apartment - and office buildings. Even walking by a baby-stroller inside an entrance, one of the video-recordings show.

Regional authorities have declared a state of emergency after the bears no longer react to noise - and light signals from guards trying to scare them off.

Belushaya Guba, like the entire Novaya Zemlya, is closed off military area. The newly upgraded air base Rogachevo is just a few kilometers outside of town.

But why don't the bears want to leave the settlement? As previously reported by the Barents Observer, the Kara Sea off the east coast of Novaya Zemlya is this winter packed with very close drift ice.

Now, it appears like the human food-waste has a much more central role in the story than just the warming Arctic.

But first a look at the many media, including the Barents Observer, that last week jumped to conclusions pointing at climate changes when the stories about polar bears in trouble, or making trouble, found its way to global newsrooms.

The blog portal Polar Bear Science has collected links to many of the newspapers reporting about the sensational images from Novaya Zemlya.

The Guardian writes, "What polar bears in a Russian apartment block reveal about the climate crisis."

image
guardian polar bear invasion

The Washington Post writes under the headline, "A 'mass invasion' of polar bears is terrorizing an island town. Climate change is to blame" and the CBC makes a similar conclusion, headlining its article: "Russian Arctic town overrun by polar bears, climate change blamed."

Mats Forsberg has sailed expeditions since 1982 and has assisted in TV productions about the polar bears in the Arctic. He has first-hand knowledge of polar bears' behavior.

"These bears are well-fed," he says to the Barents Observer after reviewing some of the videos.

"I would say these bears are not hanging around the houses due to climate changes. They have a huge amount of food dumped into nature by humans," Forsberg says and concludes: "This is purely an on-site human-made problem."

Some of the videos posted by local residents on Vkontakte show how tens of polar bears are eating garbage at the local dump site in Belushaya Guba. The bears actually look fat.

Evaluating media's reporting, the blog site Polar Bear Science concludes: "Global warming is blamed for the problem but as is so often the case, that claim does not stand up to scrutiny."

The blog is run by Susan Crockford, a zoologist with more than 35 years experience, including published work on the Holocene history of Arctic animals.



from Climate Change Skeptic Blogs via hj on Inoreader http://www.icecap.us/

[ASAP] KLi(HC3N3O3)·2H2O: Solvent-drop Grinding Method toward the Hydro-isocyanurate Nonlinear Optical Crystal

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b13280
jacsat?d=yIl2AUoC8zA


from Journals via hj on Inoreader http://bit.ly/2SMOaNj

[ASAP] Zeolitic Intermetallics: LnNiSi (Ln = La–Nd)

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b12784
jacsat?d=yIl2AUoC8zA


from Journals via hj on Inoreader http://bit.ly/2SUvT0g

[ASAP] Protein Flexibility and Stiffness Enable Efficient Enzymatic Catalysis

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b10836
jacsat?d=yIl2AUoC8zA


from Journals via hj on Inoreader http://bit.ly/2N7fMr5

[ASAP] Room-Temperature and Selective Triggering of Supramolecular DNA Assembly/Disassembly by Nonionizing Radiation

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b10355
jacsat?d=yIl2AUoC8zA


from Journals via hj on Inoreader http://bit.ly/2SPtaFr

[ASAP] The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b11027
jacsat?d=yIl2AUoC8zA


from Journals via hj on Inoreader http://bit.ly/2SWV2HI

[ASAP] Probing the Dynamics of the Imine-Based Pentafoil Knot and Pentameric Circular Helicate Assembly

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b12800
jacsat?d=yIl2AUoC8zA


from Journals via hj on Inoreader http://bit.ly/2N7fJLV

Collaboration request

Hi there How would you like to earn a 35% commission for each sale for life by selling SEO services Every website owner requires the ...