Monday, February 4, 2019

Acetylene-based two-step diastereoselective synthesis of bridgehead dihydro-oxadiazines using ketones and hydrazine as the only reactants

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C9CC00315K, Communication
Elena Schmidt, Nadezhda Semenova, Elena Ivanova, Inna Tatarinova, Igor Ushakov, A. V. Vashchenko, Boris Trofimov
Pharmaceutically related bridgehead dihydro-1,3,4-oxadiazines are synthesized in up to 94% yield by the acid-catalyzed diastereoselective reaction of hydrazine hydrate with 6,8-dioxabicyclo[3.2.1]octanes (6,8-DOBCOs), the products of the superbase-promoted self-organization of acetylene...
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