Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis

alwin shared this article with you from Inoreader Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis Via Innate Immunity In this study, we explored the pulmonary protective effect and the underlying mechanism of the NG-R1 on rats with ALI induced by severe acute pancreatitis (SAP). MiR-128-2-5p, ERK1, Tollip, HMGB1, TLR4, IκB, and NF-κB mRNA expression levels were measured using real-time qPCR, and TLR4, Tollip, HMGB1, IRAK1, MyD88, ERK1, NF-κB65, and P-IκB-α protein expression levels using Western blot. The NF-κB and the TLR4 activities were determined using immunohistochemistry, and TNF-α, IL-6, IL-1β, and ICAM-1 levels in the bronchoalveolar lavage fluid (BALF) using ELISA. Lung histopathological changes were observed in each group. NG-R1 treatment reduced miR-128-2-5p expression in the lung tissue, increased Tollip expression, inhibited HMGB1, TLR4, TRAF6, IRAK1, MyD88, NF-κB65, and p-IκB-α ex... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Circ_0026579 alleviates LPS-induced WI-38 cells inflammation injury in infantile pneumonia

alwin shared this article with you from Inoreader Circ_0026579 alleviates LPS-induced WI-38 cells inflammation injury in infantile pneumonia Via Innate Immunity Innate Immun. 2022 Jan;28(1):37-48. doi: 10.1177/17534259211069104.ABSTRACTCircular RNA (circRNA) represents an important regulator in infantile pneumonia progression. To clarify the role of circ_0026579 in this disease, LPS was used to treat WI-38 cells to mimic inflammation injury. The levels of inflammatory factors were determined by ELISA assay. Cell proliferation and apoptosis were measured by MTT assay, EdU staining and flow cytometry. The protein levels of cyclinD1, cleaved-caspase-3 and insulin-like growth factor 2 (IGF2) were examined using Western blot analysis. Cell oxidative stress was assessed by detecting MDA level and SOD activity. The expression of circ_0026579, miR-24-3p and IGF2 were analyzed using quantitative real-time PCR, and the interaction between miR-24-3p and circ... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis

alwin shared this article with you from Inoreader Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis Via Innate Immunity In this study, we explored the pulmonary protective effect and the underlying mechanism of the NG-R1 on rats with ALI induced by severe acute pancreatitis (SAP). MiR-128-2-5p, ERK1, Tollip, HMGB1, TLR4, IκB, and NF-κB mRNA expression levels were measured using real-time qPCR, and TLR4, Tollip, HMGB1, IRAK1, MyD88, ERK1, NF-κB65, and P-IκB-α protein expression levels using Western blot. The NF-κB and the TLR4 activities were determined using immunohistochemistry, and TNF-α, IL-6, IL-1β, and ICAM-1 levels in the bronchoalveolar lavage fluid (BALF) using ELISA. Lung histopathological changes were observed in each group. NG-R1 treatment reduced miR-128-2-5p expression in the lung tissue, increased Tollip expression, inhibited HMGB1, TLR4, TRAF6, IRAK1, MyD88, NF-κB65, and p-IκB-α ex... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hyperbaric Oxygen as Adjunctive Therapeutic in Management of Craniocervical Necrotizing Fasciitis: Case Series and Treatment Protocol

alwin shared this article with you from Inoreader Hyperbaric Oxygen as Adjunctive Therapeutic in Management of Craniocervical Necrotizing Fasciitis: Case Series and Treatment Protocol Via Journal of Oral and Maxillofacial Surgery Odontogenic infections are commonly encountered in OMS practices. Rarely, odontogenic infections can progress into craniocervical necrotizing fasciitis (CCNF). CCNF of the head and neck is a rare, potentially lethal disease process involving infection and subsequent destruction of fascial planes. Mortality ranges from 33% to 50% if the mediastinum is involved.1,2 CCNF diagnosis is based on clinical suspicion. Typical findings include dishwater-like purulence and easy spread of fascial planes using fingers.3 Treatment for CCNF usually consists of aggressive surgical debridement, source control, and intravenous antibiotics. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Outcomes of Oral Epithelial Dysplasia Managed by Observation versus Excision at a Canadian Tertiary Centre

alwin shared this article with you from Inoreader Outcomes of Oral Epithelial Dysplasia Managed by Observation versus Excision at a Canadian Tertiary Centre Via Journal of Oral and Maxillofacial Surgery There is a lack of consensus in the management of oral epithelial dysplasia (OED). The purpose of this study is: 1) to evaluate whether surgical excision with histologically negative margins impacts the 5-year malignant transformation rate of OED, and 2) to compare the disease-specific survival outcome of patients diagnosed with oral squamous cell carcinoma (OSCC) that progressed from OED to those presenting with OSCC on initial biopsy. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Head and Neck Langerhans Cell Histiocytosis in Children

alwin shared this article with you from Inoreader Head and Neck Langerhans Cell Histiocytosis in Children Via Journal of Oral and Maxillofacial Surgery Langerhans Cell Histiocytosis (LCH) is a sporadic myeloid neoplasm with proliferation of dendritic cells.1 In the United States, LCH has an estimated annual incidence of approximately 1 per million children.2 Controversy exists regarding management of LCH in head and neck: debridement, chemotherapy, or both. Few reports describe LCH in the OMS literature. The purpose of this study was to present experience with LCH of head and neck in children.This was a retrospective review of children with LCH at Children's Healthcare of Atlanta from 2009 to 2020. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Treatment of sagittal fracture of the mandibular condyle using resorbable-screw osteosynthesis

alwin shared this article with you from Inoreader Treatment of sagittal fracture of the mandibular condyle using resorbable-screw osteosynthesis Via Journal of Oral and Maxillofacial Surgery This study aimed to explore the applicability of resorbable-screw osteosynthesis in the treatment of SFMC. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Accuracy and precision of the CTA perforator localization technique for virtual surgical planning of composite osteocutaneous fibular free flaps in head and neck reconstruction.

alwin shared this article with you from Inoreader Accuracy and precision of the CTA perforator localization technique for virtual surgical planning of composite osteocutaneous fibular free flaps in head and neck reconstruction. Via Journal of Oral and Maxillofacial Surgery Virtual surgical planning (VSP), computer aided design/computer aided modeling (CAD/CAM), and three-dimensional (3D) printing technology have been shown to improve surgical accuracy and efficiency in head and neck reconstruction. However, persisting criticism of the technology is that it does not adequately address the soft-tissue related aspects of the reconstructive surgery. Prior publication on the computed tomographic angiography (CTA) perforator localization technique has demonstrated how soft tissue planning can be incorporated directly into existing VSP workflows. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Females Have Worse Overall and Disease-Specific Survival In HPV-Negative Oropharyngeal Squamous Cell Carcinoma

alwin shared this article with you from Inoreader Females Have Worse Overall and Disease-Specific Survival In HPV-Negative Oropharyngeal Squamous Cell Carcinoma Via Journal of Oral and Maxillofacial Surgery Although sex (male versus female) has been identified as an independent prognostic factor in human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC), the role of sex in HPV-negative OPSCC is less understood. The purpose of this study was to measure the association between sex and HPV-negative OPSCC disease-specific survival (DSS) and overall survival (OS). (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Pediatric-Antiresorptive Use: Should We Intervene on Third Molars Early?

alwin shared this article with you from Inoreader Commentary: Pediatric-Antiresorptive Use: Should We Intervene on Third Molars Early? Via Journal of Oral and Maxillofacial Surgery The recent article by Cimba et al raises an important question that has not been fully answered by the current literature.1 Pediatric patients affected by various skeletal disorders have received antiresorptive medications since around 1998.2 Historically, pamidronate has been the treatment of choice with a recent shift to zoledronate. To date, there have been no reported cases of medication related osteonecrosis of the jaws (MRONJ) in the pediatric population. The reason for this has not been fully elucidated. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Are Incisional Biopsies Reliable to Select Definitive Treatment in Patients with Ameloblastoma of the Jaws? A 15-year Interdisciplinary Retrospective Study

alwin shared this article with you from Inoreader Are Incisional Biopsies Reliable to Select Definitive Treatment in Patients with Ameloblastoma of the Jaws? A 15-year Interdisciplinary Retrospective Study Via Journal of Oral and Maxillofacial Surgery Ameloblastomas are tumors of odontogenic epithelium that, although benign, can have a locally aggressive course causing significant morbidity. WHO classifies ameloblastomas as 1 of 3 variants: solid/multicystic, unicystic, and peripheral. Resection, the standard treatment, is deemed curative, but can be debilitating to the patient. Unicystic subtype is considered less aggressive and could be treated with enucleation and curettage. The mercurial presentation of ameloblastomas makes the chosen treatment modality essential in decreasing the recurrence rates and associated morbidity. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Is Bone Grafting during Implant Placement a Protective Factor against the Development of Peri-implantitis? A Retrospective Cohort Analysis

alwin shared this article with you from Inoreader Is Bone Grafting during Implant Placement a Protective Factor against the Development of Peri-implantitis? A Retrospective Cohort Analysis Via Journal of Oral and Maxillofacial Surgery This study aims to identify if the use of bone grafting at time of implant placement is a protective factor against the development of peri-implantitis. A retrospective cohort study was conducted at the Philadelphia Veterans Affairs Medical Center from 2006 to 2013. Physician encounter notes within three months of implant placement were used to gather data about patients ' health status. Operative report notes were used to assess the use of bone grafting at time of implant placement. Implant status was assessed using dental encounter notes and radiographs from follow-up appointments at one, three, five and 10 years. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Open Reduction Internal Fixation of Mandibular Condylar Fractures: Factors Influencing Radiographic Anatomical Reduction

alwin shared this article with you from Inoreader Open Reduction Internal Fixation of Mandibular Condylar Fractures: Factors Influencing Radiographic Anatomical Reduction Via Journal of Oral and Maxillofacial Surgery Mandible fractures occur frequently, accounting for approximately 70% of all facial fractures. Of those, fractures of the mandibular condyle account for 25-35%.1,2 Over several decades, there has been much controversy over the standard treatment method for condylar fractures, with increasing support for open reduction internal fixation (ORIF). The aim of this study is to determine negative and positive factors that may influence radiographic reduction outcomes after ORIF of mandibular condylar fractures. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.