Air polishing or hand and/or power-driven instruments in supportive periodontal therapy

paythelady.61 shared this article with you from Inoreader Air polishing or hand and/or power-driven instruments in supportive periodontal therapy Via The Dental Elf This review of air polishing devices (APDs) in comparison with hand instruments and/or power-driven instruments in supportive periodontal treatment and implant maintenance included 6 RCTs. 4 of the 6 included studies were considered to be at high risk of bias so the findings should be interpreted cautiously. The post Air polishing or hand and/or power-driven instruments in supportive periodontal therapy appeared first on National Elf Service. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of stress distribution between zirconia/alloy endocrown and CAD/CAM multi-piece zirconia post-crown: three-dimensional finite element analysis

paythelady.61 shared this article with you from Inoreader Comparison of stress distribution between zirconia/alloy endocrown and CAD/CAM multi-piece zirconia post-crown: three-dimensional finite element analysis Via Latest Results for Clinical Oral Investigations Abstract Objectives This study aimed to evaluate a digital multi-piece zirconia post-crown to restore a mandibular second molar with extensive coronal loss and limited restoration space, and to compare the stress distribution between endocrowns made of zirconia or alloy and CAD/CAM multi-piece zirconia post-crowns. Material and methods Four three-dimensional finite element analysis models of a mandibular second molar with extensive coronal loss and limited restoration space were created as follows: (A) intact molar; (B) zirconia endocrown restored molar; (C) multi-piece post-crown restored-molar with tapered nail; (D) multi-piece post-crown restored molar with T-shaped nail. Models C and D were divided into two subgroups according to the material type: C1/D1, zirconia; C2/D2, NiCr alloy. The maximum modified von Mises failure criterion (mvM) stresses were calculated, and the stress distribution was recorded to analyze the effects of the restoration and material types on the biomechanical properties of dentin and prosthesis. Results The maximum mvM stress of dentin in model B (33.80 MPa) was lower compared with models C (C1, 37.81 MPa; C2, 36.36 MPa) and D (D1, 36.34 MPa; D2, 34.97 MPa) under vertical load, but the opposite was observed under oblique load. The highest mvM stress was concentrated in the nail region located in the root canal, and the T-shaped nail values were greater than the tapered nail, whereas model D with T-shaped nail showed a lower mvM stress level in dentin compared with Model C with tapered nail. Conclusions The digital multi-piece zirconia post-crown is a potential approach to restore mandibular second molars with extensive coronal loss and limited restoration space. Clinical relevance The digital multi-piece zirconia post-crown has potential to restore mandibular second molars with extensive coronal loss and limited restoration space using an innovative approach. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The implicated clinical factors for outcomes in 304 patients with salivary duct carcinoma: Multi‐institutional retrospective analysis in Japan

paythelady.61 shared this article with you from Inoreader The implicated clinical factors for outcomes in 304 patients with salivary duct carcinoma: Multi‐institutional retrospective analysis in Japan Via Head & Neck Abstract Background Salivary duct carcinoma (SDC) is a high-grade salivary malignancy that frequently occurs as the carcinomatous component of carcinoma ex pleomorphic adenoma. We herein examined the clinical factors affecting outcomes in a large cohort of SDC. Methods We selected 304 SDC cases and investigated clinical characteristics and the factors affecting outcomes. Results The median age of the cases examined was 68 years, the most common primary site was the parotid gland (238 cases), and there was a male predominance (M/F = 5:1). Outcomes were significantly worse when the primary tumor site was the minor salivary glands (SG) than when it was the major SG. Outcomes were also significantly worse in pN(+) cases (161 cases) than in pN0 cases, particularly those with a metastatic lymph node number ≥11. The cumulative incidence of relapse and distant metastases was significantly higher in stage IV cases than in stage 0–III cases. Conclusions The absolute number of lymph node metastases, higher stages, and the minor SG as the primary tumor site were identified as factors affecting the outcome of SDC. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Subclonal heterogeneity sheds light on the transformation trajectory in IGLV3-21R110 chronic lymphocytic leukemia

paythelady.61 shared this article with you from Inoreader Subclonal heterogeneity sheds light on the transformation trajectory in IGLV3-21<sup>R110</sup> chronic lymphocytic leukemia Via Blood Cancer Journal - Issue - nature.com science feeds View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

From a Slave to a Surgeon: David Kearney McDonogh, the First Black Otolaryngologist

paythelady.61 shared this article with you from Inoreader From a Slave to a Surgeon: David Kearney McDonogh, the First Black Otolaryngologist Via SAGE-Journals: Otolaryngology-Head and Neck Surgery: Table of Contents Otolaryngology–Head and Neck Surgery, Ahead of Print. David McDonogh, born into chattel slavery in Louisiana in the early 1800s, accomplished the unfathomable by becoming the first Black otolaryngologist in the United States of America. With tireless determination and profound intellect, Dr McDonogh surmounted immeasurable adversity along his improbable journey to freedom and success as an eye, ear, nose, and throat doctor in New York. His doctorate in medicine was posthumously awarded to his great-great-granddaughter in 2018 by the Columbia University Vagelos College of Physicians and Surgeons. In this History of Otolaryngology piece, we share his extraordinary story. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A Novel External Auditory Canal Squamous Cell Carcinoma Cell Line Sensitive to CDK4/6 Inhibition

paythelady.61 shared this article with you from Inoreader A Novel External Auditory Canal Squamous Cell Carcinoma Cell Line Sensitive to CDK4/6 Inhibition Via SAGE-Journals: Otolaryngology-Head and Neck Surgery: Table of Contents Otolaryngology–Head and Neck Surgery, Ahead of Print. ObjectiveTo characterize cell line CAE606 derived from a squamous cell carcinoma (SCC) of the external auditory canal (EAC) and to show its usefulness as a model for testing candidate therapeutic agents.Study DesignPreclinical translational research.SettingBiomedical research institute.MethodsThe cell line was initiated from a moderately differentiated T2N0M0 EAC SCC. We studied its histologic and genetic features as well as growth and invasion parameters. Sensitivity to cell CDK4/6 cell cycle inhibitor palbociclib was analyzed.ResultsCAE606 cells expressed heavy molecular weight cytokeratin, p63, and vimentin. The population doubling time was 25.8 hours, and the cells showed fast collective cell migration in a wound-healing assay. Short tandem repeat analysis confirmed it to be derived from the primary tumor of the patient. Next-generation sequencing revealed alterations in cell cycle regulation genes, including inact ivating mutations in CDKN2A and TP53 and high-level amplification of CCND1 and EGFR. CAE606 showed a strong decrease of phospo-Rb expression upon exposure to the CDK4/6 inhibitor palbociclib, causing significant growth inhibition with an IC50 of 0.46 µM.ConclusionThis is the first report of a stable EAC SCC cell line. Its genetic features make it a useful tool for preclinical testing of new therapeutic agents for EAC SCC, particularly those targeting cell cycle regulation in combination with radio- and chemotherapy or other specific signaling pathway inhibitors. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Systemic Steroids for Otolaryngology–Head and Neck Surgery Disorders: An Evidence-Based Primer for Clinicians

paythelady.61 shared this article with you from Inoreader Systemic Steroids for Otolaryngology–Head and Neck Surgery Disorders: An Evidence-Based Primer for Clinicians Via SAGE-Journals: Otolaryngology-Head and Neck Surgery: Table of Contents Otolaryngology–Head and Neck Surgery, Ahead of Print. ObjectiveTo offer pragmatic, evidence-informed guidance on the use of systemic corticosteroids (SCS) for common otolaryngologic disorders.Data SourcesPubMed, Cochrane Library, and American Academy of Otolaryngology–Head and Neck Surgery Foundation clinical practice guidelines.Review MethodsA comprehensive search of published literature through November 2021 was conducted on the efficacy of SCS, alone or in combination with other treatments, for managing disorders in otolaryngology and the subdisciplines. Clinical practice guidelines, systematic reviews, and randomized controlled trials, when available, were preferentially retrieved. Interventions and outcomes of SCS use were compiled to generate summary tables and narrative synthesis of findings.ConclusionsEvidence on the effectiveness of SCS varies widely across otolaryngology disorders. High-level evidence supports SCS use for Bell's palsy, sinonasal polyposis, a nd lower airway disease. Conversely, evidence is weak or absent for upper respiratory tract infection, eustachian tube dysfunction, benign paroxysmal positional vertigo, adenotonsillar hypertrophy, or nonallergic rhinitis. Evidence is indeterminate for acute laryngitis, acute pharyngitis, acute sinusitis, angioedema, chronic rhinosinusitis without polyps, Ménière's disease, postviral olfactory loss, postoperative nerve paresis/paralysis, facial pain, and sudden sensorineural hearing loss.Implications for PracticeClinicians should bring an evidence-informed lens to SCS prescribing to best counsel patients regarding the risks, anticipated benefits, and limited data on long-term effects. Alternate routes of corticosteroid administration—such as sprays, drops, inhalers, and intralesional injections—may be preferable for many disorders, particularly those that are self-limited or require a prolonged duration of therapy. Prudent use of SCS reduces the risk of medication-related ad verse effects. Clinicians who are conversant with high-level evidence can achieve optimal outcomes and stewardship when prescribing SCS. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Subclonal heterogeneity sheds light on the transformation trajectory in IGLV3-21R110 chronic lymphocytic leukemia

paythelady.61 shared this article with you from Inoreader Subclonal heterogeneity sheds light on the transformation trajectory in IGLV3-21<sup>R110</sup> chronic lymphocytic leukemia Via Blood Cancer Journal - Issue - nature.com science feeds Blood Cancer Journal, Published online: 30 March 2022; doi:10.1038/s41408-022-00650-4 Subclonal heterogeneity sheds light on the transformation trajectory in IGLV3-21R110 chronic lymphocytic leukemia View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of the Osteogenic Effectiveness of an Autogenous Demineralized Dentin Matrix and Bio-Oss® in Bone Augmentation: A Systematic Review and Meta-analysis

paythelady.61 shared this article with you from Inoreader Comparison of the Osteogenic Effectiveness of an Autogenous Demineralized Dentin Matrix and Bio-Oss® in Bone Augmentation: A Systematic Review and Meta-analysis Via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 29 March 2022 Source: British Journal of Oral and Maxillofacial Surgery Author(s): Yanfei Li, Wanhang Zhou, Peiyi Li, Qipei Luo, Anqi Li, Xinchun Zhang View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cancer Risk Associated with Continuous Positive Airway Pressure: A National Study

paythelady.61 shared this article with you from Inoreader Cancer Risk Associated with Continuous Positive Airway Pressure: A National Study Via The Laryngoscope Objective In 2021 the U.S. FDA issued a Class 1 safety recall notice for specific devices due to a risk of carcinogen exposure. The objective of this study was to evaluate reports of cancer linked to CPAP devices to understand implications for the field of sleep medicine. Methods Cases of cancer involving CPAP devices were retrieved from the MAUDE database from 2014 to 2021 and analyzed with descriptive statistics. Results A total of 2571 patient injuries were associated with CPAP. Reports of cancer (n = 209; 4.62%) were the second most commonly documented patient problem associated with CPAP, although 1950 (43.13%) patients had a device problem without an associated injury. Of the 209 cancer cases associated with CPAP, 200 (95.7%) of the adverse event reports were received by the FDA in 2021. There were 174 (9.15%) descriptions of the CPAP polyurethane sound abatement foam degrading in association with a cancer diagnosis, but degradation was more commonly not associated with malignancy (n = 1728; 90.85%). Other frequently documented CPAP device problems included broken devices (n = 279; 6.92%), fire (n = 182; 4.51%), and patient–device incompatibility (n = 144; 3.57%). Conclusion Malignancy associated with CPAP devices has been reported; however, future studies are required to establish causation. Given 95.7% of those documented cases were reported in 2021, otolaryngologists should be prepared to discuss the risks of carcinogenesis associated with CPAP. The otolaryngology community should also be aware of the potential bandwagon effect and the implications for CPAP compliance. Level of Evidence 4 Laryngoscope, 2022 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Advances in Surgical Treatment of Rhinitis

paythelady.61 shared this article with you from Inoreader Advances in Surgical Treatment of Rhinitis Via Latest Results for Current Otorhinolaryngology Reports Abstract Purpose of Review Rhinitis is a heterogeneous diagnosis characterized by the presence of several nasal symptoms and it is only when pharmacotherapy fails that surgical treatment is considered. Over the years, multiple surgical techniques and approaches have been proposed to treat these patients. We aim to present a comprehensive literature review of the surgical management of rhinitis, including the most recent techniques and long-term outcome evaluations. Recent Findings Endoscopic techniques targeting the inferior turbinates, septum, and the parasympathetic neural supply to the nasal mucosa have evolved over the years to surgically address rhinitis; better understanding of rhinitis physiopathology has prompted the development of less invasive techniques with potentially similar outcomes and decreased morbidity. Summary For the management of allergic rhinitis, isolated outfracture of the inferior turbinate remains the least invasive technique and classical submucosal resection remains very much in favor among practitioners. A variety of methods to achieve adequate submucosal reduction of the inferior turbinate are also discussed, including the microdebrider, radiofrequency ablation, and coblation techniques. Regarding non allergic rhinitis, we assess both endoscopic vidian neurectomy and posterior nasal nerve neurectomy, two broadly effective, but elaborate, options necessitating general anesthesia and a visit to the operating room. We also discuss cryoablation of the posterior nasal nerve, which presents as a minimally invasive technique that can be performed as an in-office procedure. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Key Points on Functional Rhinoplasty Patient Evaluation

paythelady.61 shared this article with you from Inoreader Key Points on Functional Rhinoplasty Patient Evaluation Via Latest Results for Current Otorhinolaryngology Reports Abstract Purpose of Review The goal of this review is to discuss the key points in the evaluation of patients for functional nasal airway surgery to help optimize outcomes. Recent Findings Development of the clinical practice guideline for rhinoplasty was a recent effort to guide perioperative care and workup of patients undergoing rhinoplasty. This guideline highlighted the importance of patient reported outcome measures (PROMs) in evaluating surgical outcomes. There has also been an increase in publications regarding intervention in the pediatric population. Finally, there has been more work into the exact mechanics of nasal airway obstruction and lateral wall insufficiency. Summary Functional rhinoplasty lacks clear objective tests to help guide surgery. PROMs are important in evaluating surgical outcomes and advances in technology such as computational fluid dynamics, and virtual surgical planning will hopefully provide insight into airflow patterns and where surgical intervention should be focused to maximize patient outcomes. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.