Tuesday, April 12, 2022

Post-Progression Treatments after Palbociclib plus Endocrine Therapy in HR+/HER2- Metastatic Breast Cancer Patients: What Is the Better Choice?

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Via Oncology
CONCLUSIONS: patients who were progressive on P+ET could still benefit from a subsequent ET. In patients who experienced a good efficacy from prior ET, without visceral metastatic sites, HT seems the most suitable option, when compared to CT, also in terms of safety.PMID:34875670 | DOI:10.1159/000521252 (Source: Oncology)
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The (extended) achondroplasia foramen magnum score has good observer reliability

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Abstract

Background

Achondroplasia is the most common skeletal dysplasia. A significant complication is foramen magnum stenosis. When severe, compression of the spinal cord may result in sleep apnea, sudden respiratory arrest and death. To avoid complications, surgical decompression of the craniocervical junction is offered in at-risk cases. However, practice varies among centres. To standardize magnetic resonance (MR) reporting, the achondroplasia foramen magnum score was recently developed. The reliability of the score has not been assessed.

Objective

To assess the interobserver reliability of the achondroplasia foramen magnum score.

Materials and methods

Base of skull imaging of children with achondroplasia under the care of Sheffield Children's Hospital was retrospectively and independently reviewed by four observers using the achondroplasia foramen magnum score. Two-way random-effects intraclass coefficient (ICC) was used to assess inter- and intra-observer reliability.

Results

Forty-nine eligible cases and five controls were included. Of these, 10 were scored normal, 17 had a median score of 1 (mild narrowing), 11 had a median score of 2 (effacement of cerebral spinal fluid), 10 had a score of 3 (compression of cord) and 6 had a median score of 4 (cord myelopathic change). Interobserver ICC was 0.72 (95% confidence interval = 0.62–0.81). Intra-observer ICC ranged from 0.60 to 0.86. Reasons for reader disagreement included flow void artefact, subtle T2 cord signal and myelopathic T2 cord change disproportionate to canal narrowing.

Conclusion

The achondroplasia foramen magnum score has good interobserver reliability. Imaging features leading to interobserver disagreement have been identified. Further research is required to prospectively validate the score against clinical outcomes.

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Retreatment of Recurrent or Second Primary Head and Neck Cancer After Prior Radiation: Executive Summary of the American Radium Society® (ARS) Appropriate Use Criteria (AUC): Expert Panel on Radiation Oncology - Head and Neck Cancer:

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Publication date: Available online 8 April 2022

Source: International Journal of Radiation Oncology*Biology*Physics

Author(s): Matthew C. Ward, Shlomo A. Koyfman, Richard L. Bakst, Danielle N. Margalit, Beth M. Beadle, Jonathan J. Beitler, Steven Shih-Wei Chang, Jay S. Cooper, Thomas J. Galloway, John A. Ridge, Jared R. Robbins, Assuntina G. Sacco, C. Jillian Tsai, Sue S. Yom, Farzan Siddiqui

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Status of IDH mutations in chondrosarcoma of the jaws

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The aim was to analyse the relationship between mutations of the isocitrate dehydrogenase gene (IDH) and clinical characteristics of chondrosarcoma of the jaw in order to provide new information on its molecular pathology. Tissue samples were collected from 25 patients diagnosed with chondrosarcoma of the jaw. IDH mutations were detected through polymerase chain reaction and direct sequencing. Clinicopathological data were analysed retrospectively. The study included 14 female and 11 male patients; the median patient age was 38 years. (Source: International Journal of Oral and Maxillofacial Surgery)
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Antibiotic-Induced Gut Microbiota Depletion Accelerates the Recovery of Radiation-Induced Oral Mucositis in Rats

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Publication date: Available online 8 April 2022

Source: International Journal of Radiation Oncology*Biology*Physics

Author(s): Ghanyah Al-Qadami, Gunjan Verma, Ysabella Van Sebille, Hien Le, Ian Hewson, Emma Bateman, Hannah Wardill, Joanne Bowen

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Acute Toxicity of Ultrahypofractionation Compared to Moderate Hypofractionation in Prostate Cancer Treatment – a Randomized Trial

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Publication date: Available online 10 April 2022

Source: International Journal of Radiation Oncology*Biology*Physics

Author(s): Winkle Kwan, Gaurav Bahl, David Kim, Allison Ye, Isabelle Gagne, Abraham Alexander, Samar Hejazi

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TCTAP C-175 Valve-In-Valve Transcatheter Aortic Valve Replacement in a Patient With Severe Left Ventricular Systolic Dysfunction in Previous Bentall Procedure

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Publication date: 19 April 2022

Source: Journal of the American College of Cardiology, Volume 79, Issue 15, Supplement

Author(s): Satej Janorkar, Sachin Shirke, Prashant Mishra, Nilesh Juvekar

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TCTAP C-176 Trans Catheter mitral Valve in Valve Replacement in a Severely Degenerated Bioprosthetic Valve

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Publication date: 19 April 2022

Source: Journal of the American College of Cardiology, Volume 79, Issue 15, Supplement

Author(s): Bhishma Chowdary Donepudi

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Long-Term Cardiovascular Outcomes After Bariatric Surgery in the Medicare Population

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Publication date: 19 April 2022

Source: Journal of the American College of Cardiology, Volume 79, Issue 15

Author(s): Amgad Mentias, Ali Aminian, Dalia Youssef, Ambarish Pandey, Venu Menon, Leslie Cho, Steven E. Nissen, Milind Y. Desai

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Principles of Surgery in Head and Neck Cutaneous Melanoma

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Surgical management of head and neck melanoma starts from the primary biopsy of the cutaneous site by a narrow excision with a 1 to 3  mm margins. The margin should include the whole breadth and sufficient depth of the lesion. The key is not to transect the lesion. With the advent of molecular testing, gene expression profiling, and immunotherapies, the surgical management of advanced melanoma has changed. Sentinel lymph node bio psy is an essential armamentarium for T2a and higher staging/greater than 1 mm thick and advance stage disease. Molecular pathogenesis and cancer immunology are recognized in the recent treatment protocols along with surgery in advanced stages of melanoma. (Source: Oral and Maxillofacial Surgery Clinics)
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Mohs Micrographic Surgery for the Treatment of Cutaneous Melanomas of the Head and Neck

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Surgical excision achieving clear histologic margins remains the mainstay treatment for primary cutaneous melanoma. Tumors of the head and neck, particularly those arising in chronically sun-damaged skin, often demonstrate extensive and asymmetric subclinical extension. Over the decades, this has proven to be a significant problem for tumors arising on the head and neck, as anatomic and functional complexities of these areas have led to suboptimal surgical treatment, yielding unacceptably high rates of local recurrence and persistently positive margins with traditional wide local excision. Patients who undergo Mohs micrographic surgery may have improved survival over those who undergo wide local excision. (Source: Oral and Maxillofacial Surgery Clinics)
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Poor Treatment Outcomes with Second-Line Chemotherapy in Advanced Synovial Sarcoma

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Via Oncology
CONCLUSION: Our exploratory study revealed that the response rate of second-line chemotherapy regimens for patients with synovial sarcoma was 9.4%. Therefore, there is an urgent need to develop more active therapeutic regimens for synovial sarcomas.PMID:35405680 | DOI:10.1159/000524500 (Source: Oncology)
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EMCrit 320 – MotR – Tension & Relaxation | Flow & Burnout

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Seek flow and avoid burnout...

EMCrit Project by Scott Weingart, MD FCCM.

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