Tripodal Molecular Propeller Perturbs Microtubule Dynamics: Indole acts as a Blade and Plays Crucial Role in Anticancer Activity

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C9CC00074G, Communication

Surajit Barman, Gaurav Das, Prasenjit Mondal, Krishnangsu Pradhan, Batakrishna Jana, Debmalya Bhunia, Abhijit Saha, Chirantan Kar, Surajit Ghosh
Indole rich tripodal microtubule inhibitor is designed, which binds at DCVJ site of tubulin and inhibits its polymerization. It causes apoptotic death of cancer cells without affecting normal cells and...
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