“Top” or “Bottom” Switches of a Cyclohexanone Monooxygenase Controlling the Enantioselectivity of the Sandwiched Substrate

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C8CC09951K, Communication

Yujing Hu, Jie Wang, Yixin Cen, He Zheng, M Huang, Xian Fu Lin, Qi Wu
Single mutation at the switch residues F432 (F432I/L) or L435 (L435A/G) efficiently reversed the inherent enantiopreference of WT CHMOAcineto in the Baeyer–Villiger oxidation of various 4-phenyl-cyclohexanone derivatives and 4-alkyl-cyclohexanones, producing...
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