Tuesday, January 8, 2019

Transition metal substituted sandwich-type polyoxometalates with a strong metal–C (imidazole) bond as anticancer agents

GA?id=C8CC07884J

Chem. Commun., 2019, Advance Article
DOI: 10.1039/C8CC07884J, Communication
Hongxia Zhao, Li Tao, Fengmin Zhang, Ying Zhang, Yanqing Liu, Hongjie Xu, Guowang Diao, Lubin Ni
The metal–carbon bond plays a pivotal role in the structural stabilities and biological activities of metal-based anticancer drugs. The strong M–Cimi bond is first introduced into sandwich-type POMs [Na0.7M5.3(H2O)2(imi)2(Himi)(SbW9O33)2]6−, (M = NiII (1), CoII (2), imi = imidazole).
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