Monday, February 18, 2019

Diastereoselective synthesis of cyclopropanes bearing trifluoromethyl-substituted all-carbon quaternary centers from 2-trifluoromethyl-1,3-enynes beyond fluorine elimination

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C9CC00785G, Communication
Shujie Chen, Jinhui Zhang, Mingfeng Yang, Fenggang Liu, Zhipeng Xie, Yun-Lin Liu, Wenxia Lin, Daru Wang, Xiangrui Li, Jiahai Wang
Here, a one-pot two-step procedure for the diastereoselective synthesis of cyclopropanes bearing trifluoromethyl-substituted all-carbon quaternary centers was described. Trifluoromethyl-activated 1,3-enynes undergo cyclopropanation reactions with sulfur ylides under mild reaction conditions...
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