An efficient, step-economical strategy for the design of functional metalloproteins

An efficient, step-economical strategy for the design of functional metalloproteins

An efficient, step-economical strategy for the design of functional metalloproteins, Published online: 18 February 2019; doi:10.1038/s41557-019-0218-9

A concise strategy for engineering functional, supramolecular protein complexes has now been developed based on single-mutation-mediated covalent tethering. Metalloproteins designed with this method can sustain large alterations to the metal coordination environment, bind small molecules, exhibit reversible redox activity and sustain large alterations to the protein structure.

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