Friday, January 4, 2019

Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines.

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C8CC08769E, Communication
Natalia Curado, Guillaume Dewaele-LeRoi, Sophie Poty, Jason S Lewis, Maria Contel
We describe the preparation of gold(I)-compounds that are amenable to efficient bioconjugation with monoclonal antibodies via activated ester or maleimide linkers. New Trastuzumab-gold conjugates were synthesized and fully characterized. These...
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