The formation of all-cis-(multi)fluorinated piperidines by a dearomatization–hydrogenation process

The formation of all-cis-(multi)fluorinated piperidines by a dearomatization–hydrogenation process

The formation of all-<i>cis</i>-(multi)fluorinated piperidines by a dearomatization–hydrogenation process, Published online: 21 January 2019; doi:10.1038/s41557-018-0197-2

Despite their huge potential in medicinal chemistry, current approaches for the synthesis of fluorinated piperidines are often impractical. A straightforward process for the rhodium-catalysed dearomatization–hydrogenation of fluoropyridines has now been described. This strategy enables the highly diastereoselective formation of a variety of all-cis-(multi)fluorinated piperidines and the study of their conformational behaviour.

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