Monday, January 7, 2019

A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C8CC09435G, Communication
Hidenori Okamura, Sidney Becker, Niklas Tiede, Stefan Wiedemann, Jonas Feldmann, Thomas Carell
Herein, we report a new prebiotically plausible pathway towards a pyrimidine nucleobase in continuous manner. The route involves simultaneous methylation and carbamoylation of cyanoacetylene-derived α,β-unsaturated thioamide with N-methyl-N-nitrosourea (MNU) in...
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