In Vivo Comparison of Three Human Acellular Dermal Matrices for Breast Reconstruction

xlomafota13 shared this article with you from Inoreader <em>In Vivo</em> Comparison of Three Human Acellular Dermal Matrices for Breast Reconstruction Via In vivo (Athens, Greece) In Vivo. 2021 Sep-Oct;35(5):2719-2728. doi: 10.21873/invivo.12556. ABSTRACT BACKGROUND/AIM: Acellular dermal matrices (ADMs) have become popular in implant-based breast reconstruction. The aim of this study was to compare three commonly used ADM products in vivo in an animal model. MATERIALS AND METHODS: The nucleic acid content (residual double-stranded DNA) and the levels of the remaining growth factors after decellularization were measured for each ADM. Cytocompatibility with ADMs was documented using NIH 3T3 mouse fibroblast cells. In vivo, the implanted ADMs were histologically evaluated at 1, 2, 3, and 6 months (n=5) using male 8-week-old Sprague-Dawley rats. RESULTS: Fibroblasts grew in the SureDerm HD and DermACELL with no cytotoxicity. In a rat model, SureDerm HD and DermACELL incorporated more readily into the surrounding host tissue, as measured by rapid cell influx and collagen deposition, and showed more delaye d tissue remodeling with decreased matrix metalloproteinases levels compared to AlloDerm. CONCLUSION: SureDerm HD and DermACELL can be used as biological materials for breast reconstruction. PMID:34410961 | DOI:10.21873/invivo.12556 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.