Thursday, August 19, 2021

Establishment of an Experimental System for Intraperitoneal Chemotherapy in a Rat Model

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In Vivo. 2021 Sep-Oct;35(5):2703-2710. doi: 10.21873/invivo.12554.

ABSTRACT

AIM: To establish an experimental system for comparing different methods of intraperitoneal chemotherapy in a rat model.

MATERIALS AND METHODS: We used six-week-old Sprague-Dawley rats, and created an early postoperative intraperitoneal chemotherapy (EPIC) system using 18-gauge syringes and evacuators, and a hyperthermic intraperitoneal chemotherapy (HIPEC) system using two peristaltic pumps which controlled the flow rate and temperature. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) was achieved using a nozzle for dispersing aerosols at a flow rate up to 41.5 ml/min. The distribution and intensity of 0.2% trypan blue dye was compared among three methods.

RESULTS: The distribution was limited and the intensity was weak after EPIC, and the dye stained moderately in gravity-dependent regions after HIPEC. On the other hand, the distribution was the most comprehensive, and the intensity was the greatest after PIPAC.

CONCLUSION: This experimental system in a rat model may reflect the comparative effect among EPIC, HIPEC and PIPAC in humans.

PMID:34410959 | DOI:10.21873/invivo.12554

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