Tuesday, March 2, 2021

Effect of rifampicin on anticoagulation of warfarin: A case report

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World J Clin Cases. 2021 Feb 16;9(5):1087-1095. doi: 10.12998/wjcc.v9.i5.1087.

ABSTRACT

BACKGROUND: The drug interaction between warfarin and rifampicin is widely known, but there are still some difficulties in managing the combination of the two drugs.

CASE SUMMARY: A patient with brucellosis received strict monitoring from a Chinese pharmacist team during combination of warfarin and rifampicin. The dose of warfarin was increased to 350% in 3 mo before reaching the lower international normalized ratio treatment window. No obvious adverse reaction occurred during the drug-adjustment period. This is the first case report of long-term combined use of rifampicin and warfarin in patients with brucellosis and valve replacement in China based on the Chinese lower warfarin dose and international normalized ratio range.

CONCLUSION: Anticoagulation for valve replacement in Chinese patients differs from that in other races. Establish ment of a pharmacist clinic provides vital assistance in warfarin dose adjustment.

PMID:33644171 | PMC:PMC7896655 | DOI:10.12998/wjcc.v9.i5.1087

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