Chronic myelomonocytic leukemia-associated pulmonary alveolar proteinosis: A case report and review of literature

paythelady.612 shared this article with you from Inoreader Chronic myelomonocytic leukemia-associated pulmonary alveolar proteinosis: A case report and review of literature Μέσω pubmed: "world j clin cases"... World J Clin Cases. 2021 Feb 16;9(5):1156-1167. doi: 10.12998/wjcc.v9.i5.1156. ABSTRACT BACKGROUND: Pulmonary alveolar proteinosis (PAP) is a rare condition that can cause progressive symptoms including dyspnea, cough and respiratory insufficiency. Secondary PAP is generally associated with hematological malignancies including chronic myelomonocytic leukemia (CMML). To the best of our knowledge, this is the first reported case of PAP occurring secondary to CMML. CASE SUMMARY: We report the case of a 63-year-old male who presented with a recurrent cough and gradually progressive dyspnea in the absence of fever. Based upon clinical symptoms, computed tomography findings, bone marrow aspiration, flow cytometry studies and cytogenetic analyses, the patient was diagnosed with PAP secondary to CMML. He underwent whole lung lavage in March 2016 to alleviate his dyspnea, after which he began combined chemotherapeutic treatment with decit abine and cytarabine. The patient died in January 2020 as a consequence of severe pulmonary infection. CONCLUSION: This case offers insight regarding the mechanistic basis for PAP secondary to CMML and highlights potential risk factors. PMID:33644180 | PMC:PMC7896663 | DOI:10.12998/wjcc.v9.i5.1156 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.