A four‐gene signature (NCF2, MYO1F, S1PR4, and FCN1) alone or combined with two risk factors (male sex and hyperlipidemia) could act as a noninvasive diagnostic biomarker for obstructive coronary artery disease (CAD) and ST‐segment elevation myocardial infarction (STEMI). Abstract This study aims to explore the predictive noninvasive biomarker for obstructive coronary artery disease (CAD). By using the data set GSE90074, weighted gene co‐expression network analysis (WGCNA), and protein–protein...
Thu Jun 27, 2019 22:00
A dominantly inherited form of early‐onset dystonia 16 (DYT16) has been identified to arise due to a frameshift (FS) mutation in P rotein Act ivator (PACT). To examine the effect of the resulting truncated mutant PACT protein on the RNA‐activated protein kinase (PKR) pathway, we examined the biochemical properties of the mutant protein and its effect on mammalian cells. Our results indicate that the FS mutant protein forms aggregates in cells and activates PKR leading to caspase activation...
Thu Jun 27, 2019 15:59
The present study aims to investigate the mechanism of simvastatin stimulates osteogenic differentiation in rat BMSCs, specifically focus on the role of Hedgehog signaling pathway, through identifying Gli1‐interacting proteins during this process, and present a model of the molecular network for the osteogenic response of BMSCs to simvastatin stimulation. Abstract Simvastatin has been shown to promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Our study aimed to...
Thu Jun 27, 2019 15:15
Cardio‐annulation was discovered during an in vitro culture of cardiac cells. The structure contains cardiomyocytes, fibroblasts, telocytes, and abundant stem cells. These results provide insight into the relationship among cardiac cells in vitro. Abstract To explore the formation, morphological characteristics, cell composition, and differentiation potential of cardiomyocyte annulation (cardio‐annulation) during in vitro culture of cardiac cells. Cardiac cells were isolated and cultured. A live‐cell...
Thu Jun 27, 2019 15:14
Constant oxygen treatment exerts a promotive effect without significant oxidative stress injury in lung development of preterm rat neonates. Whlie intermittent hyperoxia and hypoxia inhibited lung development, decreased antioxidative capacity, and dysregulated HIF‐1α/VEGF signaling in preterm rat neonates. Abstract Impaired lung development is a major negative factor in the survival of preterm neonates. The present study was aimed to investigate the impact of constant oxygen, intermittent hyperoxia,...
Thu Jun 27, 2019 15:14
Abstract Thyroid cancer (TC) is one of the primary tumors arisen from endocrine system. The purpose of this study was to investigate the underlying mechanism by which RAP1B (Ras‐related protein Rap‐1b) modulates microRNA (miR)‐206 related effects on TC cells. Expression of miR‐206 and RAP1B was analyzed in cells and tissues. miR‐206 mimics or inhibitors and RAP1B vector were used in functional experiments to investigate the effects of miR‐206 and RAP1B on cell activities including proliferation,...
Thu Jun 27, 2019 15:12
Saffron and its active pharmacological constituents modulate the pathogenesis of cancer via regulating apoptosis, cell proliferation, cell cycle progression, oxidation‐reduction state, and inflammation. This review summarizes the recent findings regarding the chemopreventive properties of saffron in gastrointestinal cancers for a better understanding and hence better management of these malignancies. Abstract Gastrointestinal (GI) cancers are major causes of cancer‐related mortality worldwide and...
Thu Jun 27, 2019 15:12
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