lncRNA HNF1A‐AS1 was induced in both NSCLC tumor tissues and cell lines HNF1A‐AS1 induced NSCLC cell proliferation and cell cycle HNF1A‐AS1 induced NSCLC cell migration and invasion. Abstract Growing evidence have shown the important regulation of lncRNAs (long noncoding RNAs) in non–small cell lung cancer (NSCLC). lncRNA hepatocyte nuclear factor 1 homeobox A (HNF1A)‐antisense RNA 1 (AS1), an “oncogene”, was reported to regulate human tumors progression. However, the molecular mechanism of...
Wed Jun 26, 2019 21:17
1. DEX alleviates LPS triggered renal oxidative stress. 2. DEX ameliorates LPS‐induced renal inflammatory response. 3. DEX inhibits NLRP3 inflammasome activation via TLR4/NOX4/NF‐κB pathway in LPS induced kidney injury. 4. DEX attenuates LPS‐induced acute kidney injury by acting on α2AR, but not IR. Abstract Dexmedetomidine (DEX) prevents kidney damage caused by sepsis, but the mechanism of this effect remains unclear. In this study, the protective molecular mechanism of DEX in lipopolysaccharide...
Wed Jun 26, 2019 21:15
Graphic summary of phenotype of Bif‐1−/− mice. Abstract Skeletal tissue homeostasis is maintained via the balance of osteoclastic bone resorption and osteoblastic bone formation. Autophagy and apoptosis are essential for the maintenance of homeostasis and normal development in cells and tissues. We found that Bax‐interacting factor 1 (Bif‐1/Endophillin B1/SH3GLB1), involving in autophagy and apoptosis, was upregulated during osteoclastogenesis. Furthermore, mature osteoclasts expressed Bif‐1...
Wed Jun 26, 2019 21:15
miR‐488‐3p inhibited cell proliferation and induced cell apoptosis in esophageal squamous cell carcinoma (ESCC). miR‐488‐3p targeted zinc finger and BTB domain containing 2 (ZBTB2) in ESCC cells. miR‐488‐3p regulated p53 pathway through ZBTB2 in ESCC. ZBTB2 was required for the regulation of miR‐488‐3p on cell proliferation and apoptosis in ESCC. Abstract Esophageal squamous cell carcinoma (ESCC) is the eighth most prevalent cancer and the sixth leading cause for cancer‐associated mortality....
Wed Jun 26, 2019 21:14
In summary, the results of our study indicate that miR‐579 could function as a tumor suppressor gene. However, according to our findings the simultaneous use of this miRNA, along with standard clinical therapies may improve the treatment of glioblastoma tumors. Of course, this needs to be investigated further in the in vivo. Abstract Glioblastoma multiform (GBM) is a type of aggressive brain cancer with limited success in standard treatment. MicroRNAs are one of the most beneficial tools for...
Wed Jun 26, 2019 21:13
Cyclin D1 polymorphisms may lead to uncontrolled cell proliferation. G870A single‐nucleotide polymorphism influences breast cancer risk. Our study shows that AA genotype is significantly associated with breast cancer risk. Abstract Background Cyclin D1 (CCND1) polymorphisms, a regulator of the cell cycle progress from G1 to the S phase, may lead to uncontrolled cell proliferation and lack of apoptosis. G870A, a common single‐nucleotide polymorphism in CCND1 influences breast cancer risk. However,...
Wed Jun 26, 2019 21:13
1. With the development in research, the importance of microRNAs (miRNAs) in the occurrence and metastasis, and prognosis of lung squamous cell carcinoma (LUSC) have received extensive attention. And through mining the The Cancer Genome Atlas database, we constructed the miRNA‐mRNA interaction network and performed a series of bioinformatics analyses of differential miRNAs and mRNAs in LUSC. 2. Six pivotal genes (DLGAP5, CENPA, CHEK1, CALB1, LRRK2, and TOP2A), which are directly or indirectly involved...
Wed Jun 26, 2019 15:10
MAMs formation is increased in endothelial cells under hypoxia. Disruption of mitochondria‐associated membrane (MAM) restores mitochondrial function in Ca2+m, respiration, reactive oxygen species (ROS), and mitochondrial membrane potential. Thus, hypoxia‐induced inflammation and apoptosis are attenuated and nitric oxide synthesis is promoted. Abstract Mitochondrial dysfunction plays a principal role in hypoxia‐induced endothelial injury, which is involved in hypoxic pulmonary hypertension and...
Wed Jun 26, 2019 15:10
The study found that circRNA hsa_circ_0014130 (circPIP5K1A) acted as a tumor promoter through a novel circPIP5K1A/miR‐600/HIF‐1α axis, which provides candidate markers and therapeutic targets for non‐small cell lung cancer (NSCLC) Abstract Circular RNAs (circRNAs) have an important function in human diseases, especially in cancer. circRNA hsa_circ_0014130 (circPIP5K1A), a particularly abundant circRNA, participates in the tumorigenesis of non‐small cell lung cancer (NSCLC), although the underlying...
Wed Jun 26, 2019 15:09
No comments:
Post a Comment