Wednesday, January 23, 2019

Sterol A-ring plasticity in hedgehog protein cholesterolysis supports a primitive substrate selectivity mechanism

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Chem. Commun., 2019, Advance Article
DOI: 10.1039/C8CC09729A, Communication
Daniel A. Ciulla, Andrew G. Wagner, Xinyue Liu, Courtney L. Cooper, Michael T. Jorgensen, Chunyu Wang, Puja Goyal, Nilesh K. Banavali, John L. Pezzullo, José-Luis Giner, Brian P. Callahan
The enzymatic agent of hedgehog protein cholesterolysis accommodates substrate sterols with undersized, oversized and distorted ring systems relative to cholesterol.
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