How specific molecular-targeted agents can make obsolete a 'one size fits all' approach in EGFR-mutated NSCLC treatment (Review)

xlomafota13 shared this article with you from Inoreader How specific molecular-targeted agents can make obsolete a 'one size fits all' approach in <em>EGFR</em>-mutated NSCLC treatment (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Oct;22(4):1150. doi: 10.3892/etm.2021.10584. Epub 2021 Aug 10. ABSTRACT Despite many advances in the latest period, lung cancer remains the cancer with the highest mortality. The latest developments concerning lung cancer treatment have changed the clinical practice by prolonging patient survival; however, unfortunately, there remains a high mortality rate firstly due to disease aggressivity and secondly through lack of early diagnosis and screening programs. Currently, researchers and clinicians are talking about personalized cancer treatment, and a complete diagnostic evaluation should consider, in addition to staging and histology, molecular aberrations, and genetics of the tumor tissue. The development of tyrosine kinase inhibitors (TKIs) has led to an improvement in survival for patients with EGFR mutations, this being the most studied driver mutation in adenocarcinoma; and at the same time an important predicti ve factor for patient outcome following the treatment with TKIs. Reseach must investigate the different TKI combination strategies in order to overcome resistance and to increase patient survival. Currently, there are ongoing clinical trials that will probably change the therapeutic approach for EGFR-mutated advanced or metastatic NSCLC patients. PMID:34504595 | PMC:PMC8393358 | DOI:10.3892/etm.2021.10584 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.