Tuesday, February 23, 2021

Patient iPSC-derived retinal organoids: Observable retinal diseases in-a-dish

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Histol Histopathol. 2021 Jan 22:18307. doi: 10.14670/HH-18-307. Online ahead of print.

ABSTRACT

Induced pluripotent stem cells (iPSCs), reprogrammed from human somatic cells, hold the capacity to differentiate into most human body cells. iPSCs can be differentiated into retinal organoids, a three-dimensional structured retina containing various retinal cells. Patient-specific retinal organoids provide a powerful disease model to recapitulate the disease to study the pathogenesis of inherited retinal dystrophies, to screen or discover new drugs, and most importantly to supply an unlimited cell source for retinal regeneration.

PMID:33491763 | DOI:10.14670/HH-18-307

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