Neuromodulation of the anterior thalamic nucleus as a therapeutic option for difficult-to-control epilepsy

xlomafota13 shared this article with you from Inoreader Neuromodulation of the anterior thalamic nucleus as a therapeutic option for difficult-to-control epilepsy Via Sociedad Luso-Española de Neurocirugía Neurocirugia (Astur). 2021 Feb 4:S1130-1473(21)00002-6. doi: 10.1016/j.neucir.2020.12.001. Online ahead of print. ABSTRACT Deep brain stimulation (DBS) consists of the electrical stimulation of the subcortical structures by implanting electrodes connected to a pulse generator. The thalamus, being a structure that has multiple connections with various parts of the central nervous system, is a suitable target for DBS. The anterior thalamic nucleus (ANT) serves as an important relay site for the limbic system by receiving input from the hippocampus and mammillary bodies, and sending input to the cingulate gyrus; thus forming the Papez circuit. Due to these connections, the ANT constitutes an ideal route for the propagation of epileptogenic activity. ANT-DBS has excellent results in the control of complex partial seizures. The vast majority of patients with ANT-DBS have shown a significant reduction in the frequency of their seizures of more than 50%. PMID:33551281 | DOI:10.1016/j.neucir.2020.12.001 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.