Monday, December 7, 2020

Leukotriene D4 Paradoxically Limits LTC4 Driven Platelet Activation and Lung Immunopathology

pa.ythelady61 shared this article with you from Inoreader
Capsule summary. LTD4, the conversion product of LTC4, potently elicits bronchoconstriction, but blocks LTC4-induced platelet activation, pulmonary eosinophilia, and IL-33 induction through CysLT2R. Conversion to LTD4 may limit the severity of allergic inflammation potentiated by LTC4 production.
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