Atopic dermatitis (AD) has now been well documented to be associated with an important impact on quality of life and is a major driver of not only systemic comorbidities including other allergic diseases (such as asthma and food allergy) but also cardiovascular and autoimmune diseases.1 Sleep disturbance and adverse effects on mental health are common in patients with AD. A major contributor for these events is the skin and resultant systemic immune activation associated with AD.2 Recent studies support the importance of skin barrier dysfunction in driving cutaneous allergy.
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