Switching two Nitrilase Regioselectivity toward Succinonitrile by Mutating the Active Center Pocket Key Residues Through a Semi-Rational Engineering

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C8CC10110H, Communication

zhi chen, Shuiqing Jiang, Hualei Wang, Liuzhu Wang, Dongzhi Wei
The 163Ala in bll6402NIT and 172Trp in blr3397NIT played a significant role in directing nitrilase regioselectivity. Amino acid mutation of two nitrilases in this two sites could alter the size...
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