Wednesday, February 13, 2019

PROTACs suppression of CDK4/6, crucial kinases for cell cycle regulation in cancer

GA?id=C9CC00163H

Chem. Commun., 2019, Advance Article
DOI: 10.1039/C9CC00163H, Communication
Bosheng Zhao, Kevin Burgess
PROTACs based on two selective, FDA approved, CDK4/6 inhibitors were formed. These PROTACs at nanomolar concentrations deplete CDK4/6.
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