Wednesday, February 27, 2019

Design of Specific Inhibitors of Quinolinate Synthase based on [4Fe-4S] Cluster Coordination

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C8CC09023H, Communication
Sandrine Ollagnier de Choudens, Jaione Saez Cabodevilla, Anne Volbeda, olivier hamelin, Jean-Marc Latour, océane Gigarel, Martin Clémancey, Claudine Darnault, Debora Reichmann, Patricia Amara, Juan C. Fontecilla-Camps
Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of...
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