Supercharging enables organized assembly of synthetic biomolecules

Supercharging enables organized assembly of synthetic biomolecules

Supercharging enables organized assembly of synthetic biomolecules, Published online: 14 January 2019; doi:10.1038/s41557-018-0196-3

Symmetrical protein oligomers perform key structural and catalytic functions in nature, but engineering such oligomers synthetically is challenging. Now, oppositely supercharged synthetic variants of normally monomeric proteins have been shown to assemble via specific, introduced electrostatic contacts into symmetrical, highly well-defined oligomers.

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