Tuesday, January 22, 2019

Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture

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Chem. Commun., 2019, 55,1020-1023
DOI: 10.1039/C8CC07706A, Communication
Open Access Open Access
Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jacob T. Bush, Robert K. Leśniak, Tzu-Lan Yeh, Roman Belle, Holger Kramer, Anthony Tumber, Rasheduzzaman Chowdhury, Emily Flashman, Jasmin Mecinović, Christopher J. Schofield
We describe covalently binding modulators of the activity of human prolyl hydroxylase domain 2 (PHD2) and studies towards a strategy for photocapture of PHD2 substrates.
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