Tuesday, January 22, 2019

A clickable glutamine (CliQ) derivative for the traceless reversible modification of peptides and proteins

Chem. Commun., 2019, Accepted Manuscript
DOI: 10.1039/C8CC09404G, Communication
Samuel D Whedon, Marissa K Parker, Elizabeth L Tyson, Tobias Ritterhoff, Patrick Shelton, Champak Chatterjee
The Cu(I)-mediated click reaction of proteins with affinity tags enables their selective isolation from complex mixtures. However, irreversible protein modification limits the interpretation of results from subsequent biophysical and biochemical...
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