Mental Fatigue Has Great Impact on the Fractal Dimension of Brain Functional Network

alkiviadis.1961 shared this article with you from Inoreader Mental Fatigue Has Great Impact on the Fractal Dimension of Brain Functional Network Via Hindawi Publishing Corporation Mental fatigue has serious negative impacts on the brain cognitive functions and has been widely explored by the means of brain functional networks with the neuroimaging technique of electroencephalogram (EEG).tempspacetempspaceRecently, several researchers reported that brain functional network constructed from EEG signals has fractal feature, raising an important question: what are the effects of mental fatigue on the fractal dimension of brain functional network? In the present study, the EEG data of alpha1 rhythm (8-10 Hz) at task state obtained by a mental fatigue model were chosen to construct brain functional networks.tempspacetempspaceA modified greedy colouring algorithm was proposed for fractal dimension calculation in both binary and weighted brain functional networks.tempspacetempspaceThe results i ndicate that brain functional networks still maintain fractal structures even when the brain is at fatigue state; fractal dimension presented an increasing trend along with the deepening of mental fatigue fractal dimension of the weighted network was more sensitive to mental fatigue than that of binary network.tempspacetempspaceOur current results suggested that mental fatigue has great regular impacts on the fractal dimension in both binary and weighted brain functional networks. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Curcumin for Protecting the Kidney with Ischemia Reperfusion Injury

alkiviadis.1961 shared this article with you from Inoreader A Preclinical Systematic Review of Curcumin for Protecting the Kidney with Ischemia Reperfusion Injury Via Hindawi Publishing Corporation Renal ischemia-reperfusion injury (RIRI) refers to a phenomenon associated with dysfunction of the kidney and tissue damage.tempspacetempspaceUnfortunately, no specific drugs have been found that effectively prevent and treat RIRI.tempspacetempspaceCurcumin (Cur), a polyphenol extracted from turmeric, possesses a variety of biological activities involving antioxidation, inhibition of apoptosis, inhibition of inflammation, and reduction of lipid peroxidation.tempspacetempspaceEight frequently used databases were searched using prespecified search strategies.tempspacetempspaceThe CAMARADES 10-item quality checklist was used to evaluate the risk of bias of included studies, and the RevMan 5.3 software was used to analyze the data.tempspacetempspaceThe risk of bias score of included studies ranged from 3 to 6 with an average score of 5.22.tempspacetempspaceCompared with the control group, Cur significantly alleviated renal pathology, reduced blood urea nitrogen and serum creatinine levels, and improved inflammatory indexes, oxidant, and apoptosis in RIRI animal models.tempspacetempspaceDespite the heterogeneity of the response to Cur in terms of serum creatinine, BUN, TNF-alpha, and SOD, its effectiveness for improving the injury of RIRI was remarkable.tempspacetempspaceIn the mouse model subgroup of serum creatinine, the effect size of the method of unilateral renal artery ligation with contralateral nephrectomy and shorter ischemic time showed a greater effect than that of the control group.tempspacetempspaceNo difference was seen in the methods of model establishment, mode administration, or medication times.tempspacetempspaceThe preclinical systematic review provided preliminary evidence that Cur partially improved RIRI in animal models, probably via anti-inflammatory, antioxidant, a ntiapoptosis, and antifibrosis activities and via improving microperfusion.tempspacetempspaceARRIVE guidelines are recommended; blinding and sample size calculation should be focused on in future studies.tempspacetempspaceThese data suggest that Cur is a potential renoprotective candidate for further clinical trials of RIRI. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Age-Related Change of Axial Length, Spherical Equivalent, and Prevalence of Myopia and High Myopia in School-Age Children

alkiviadis.1961 shared this article with you from Inoreader Age-Related Change of Axial Length, Spherical Equivalent, and Prevalence of Myopia and High Myopia in School-Age Children in Shanghai: 2014–2018 Via Hindawi Publishing Corporation Purpose. To investigate the age-related change of axial length (AL), spherical equivalent (SE), and prevalence of myopia and high myopia in children at 7–18-year-olds in Shanghai in 2014 and 2018, respectively. Methods. This was an observational study in Shanghai. The same 3 schools were selected in 2014 and 2018, respectively. AL, SE, prevalence of myopia and high myopia, height, and weight were measured. A questionnaire regarding the lifestyles was completed. Results. Mean age was smaller in 2018 than in 2014 (), and mean AL was shorter in 2018 than in 2014 (), whereas mean SE was greater in 2018 than in 2014 (). The prevalence of myopia and high myopia was lower in 2018 than in 2014 ( and , respectively). Mean AL increased with age from 7-year-olds to 18-year-olds in 2014 and 2018 (both ), respectivel y. Mean SE decreased with age in 2014 and 2018 (both ), respectively. The prevalence of myopia and high myopia increased with age in 2014 and 2018 (all ), respectively. Less mean time outdoors and more mean time of study of all children were observed in 2018 than in 2014 ( and , respectively). Conclusion. This study shows normative growth values for AL and SE in Shanghai children at the age of 7–18-year-olds, as well as the age-specific prevalence of myopia and high myopia. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Investigation of the miRNA and mRNA Coexpression Network and Their Prognostic Value in Hepatocellular Carcinoma

alkiviadis.1961 shared this article with you from Inoreader Investigation of the miRNA and mRNA Coexpression Network and Their Prognostic Value in Hepatocellular Carcinoma Via Hindawi Publishing Corporation Purpose. To identify pivotal differentially expressed miRNAs and genes and construct their regulatory network in hepatocellular carcinoma. Methods. mRNA (GSE101728) and microRNA (GSE108724) microarray datasets were obtained from the NCBI Gene Expression Omnibus (GEO) database. Then, we identified the differentially expressed miRNAs and mRNAs. Sequentially, transcription factor enrichment and gene ontology (GO) enrichment analysis for miRNA were performed. Target genes of these differential miRNAs were obtained using packages in language ( package multiMiR). After that, downregulated miRNAs were matched with target mRNAs which were upregulated, while upregulated miRNAs were paired with downregulated target mRNA using scripts written in Perl. An miRNA-mRNA network was constructed and visualized in Cytoscape software. For miRNAs in the network, survival analysis was performed. And for genes in the network, we did gene ontology (GO) and KEGG pathway enrichment analysis. Results. A total of 35 miRNAs and 295 mRNAs were involved in the network. These differential genes were enriched in positive regulation of cell-cell adhesion, positive regulation of leukocyte cell-cell adhesion, and so on. Eight differentially expressed miRNAs were found to be associated with the OS of patients with HCC. Among which, miR-425 and miR-324 were upregulated while the other six, including miR-99a, miR-100, miR-125b, miR-145, miR-150, and miR-338, were downregulated. Conclusion. In conclusion, these results can provide a potential research direction for further studies about the mechanisms of how miRNA affects malignant behavior in hepatocellular carcinoma. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Gut Microbiota-Bile Acid Crosstalk in Diarrhea-Irritable Bowel Syndrome

alkiviadis.1961 shared this article with you from Inoreader Gut Microbiota-Bile Acid Crosstalk in Diarrhea-Irritable Bowel Syndrome Via Hindawi Publishing Corporation The occurrence of diarrhea-predominant irritable bowel syndrome (IBS-D) is the result of multiple factors, and its pathogenesis has not yet been clarified.tempspacetempspaceEmerging evidence indicates abnormal changes in gut microbiota and bile acid (BA) metabolism have a close relationship with IBS-D.tempspacetempspaceGut microbiota is involved in the secondary BA production via deconjugation, 7α-dehydroxylation, oxidation, epimerization, desulfation, and esterification reactions respectively.tempspacetempspaceChanges in the composition and quantity of gut microbiota have an important impact on the metabolism of BAs, which can lead to the occurrence of gastrointestinal diseases.tempspacetempspaceBAs, synthesized in the hepatocytes, play an important role in maintaining the homeostasis of gut microbiota a nd the balance of glucose and lipid metabolism.tempspacetempspaceIn consideration of the complex biological functional connections among gut microbiota, BAs, and IBS-D, it is urgent to review the latest research progress in this field.tempspacetempspaceIn this review, we summarized the alterations of gut microbiota in IBS-D and discussed the mechanistic connections between gut microbiota and BA metabolism in IBS-D, which may be involved in activating two important bile acid receptors, G-protein coupled bile acid receptor 1 (TGR5) and farnesoid X receptor (FXR).tempspacetempspaceWe also highlight the strategies of prevention and treatment of IBS-D via regulating gut microbiota-bile acid axis, including probiotics, fecal microbiota transplantation (FMT), cholestyramine, and the cutting-edge technology about bacteria genetic engineering. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Identification of Monotonically Differentially Expressed Genes across Pathologic Stages for Cancers

alkiviadis.1961 shared this article with you from Inoreader Identification of Monotonically Differentially Expressed Genes across Pathologic Stages for Cancers Via Hindawi Publishing Corporation Given the fact that cancer is a multistage progression process resulting from genetic sequence mutations, the genes whose expression values increase or decrease monotonically across pathologic stages are potentially involved in tumor progression.tempspacetempspaceThis may provide insightful clues about how human cancers advance, thereby facilitating more personalized treatments.tempspacetempspaceBy replacing the expression values of genes with their GeneRanks, we propose a procedure capable of identifying monotonically differentially expressed genes (MEGs) as the disease advances.tempspacetempspaceUsing three real-world gene expression data that cover three distinct cancer types—colon, esophageal, and lung cancers—the proposed procedure has demonstrated excellent performance in detecting the potential MEGs.t empspacetempspaceTo conclude, the proposed procedure can detect MEGs across pathologic stages of cancers very efficiently and is thus highly recommended. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Estimation of the Content of Selected Active Substances in Primary and Secondary Herbal Brews by UV-VIS and GC-MS Spectroscopic Analyses

alkiviadis.1961 shared this article with you from Inoreader Estimation of the Content of Selected Active Substances in Primary and Secondary Herbal Brews by UV-VIS and GC-MS Spectroscopic Analyses Via Hindawi Publishing Corporation Primary and secondary herbal brews were tested for the content of polyphenolic compounds, flavonoids, and essential oil.tempspacetempspaceThe brewing process was carried out at an initial temperature of 95°C and different time parameters (5, 10, 15, and 30 min).tempspacetempspaceA secondary brewing was also carried out to estimate the reuse of the herbal material.tempspacetempspaceThe highest content of polyphenol compounds and flavonoids was determined in the primary peppermint brews (4017 mg L−1 and 360 mg L−1, respectively).tempspacetempspaceThe secondary brews were characterised by a lower content of active substances than the primary brews.tempspacetempspaceThe study showed that the herbal postbrewing material contained significant levels of essential oil (from 13.04% to 95.65%) and may be an alternative source of volatile bioactive compounds. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Analysis of a Fractional Reaction-Diffusion HBV Model with Cure of Infected Cells

alkiviadis.1961 shared this article with you from Inoreader Analysis of a Fractional Reaction-Diffusion HBV Model with Cure of Infected Cells Via Hindawi Publishing Corporation In this paper, we propose a fractional reaction-diffusion model in order to better understand the mechanisms and dynamics of hepatitis B virus (HBV) infection in human body. The infection transmission is modeled by Hattaf–Yousfi functional response, and the fractional derivative is in the sense of Caputo. The global stability of the model equilibria is analyzed by means of Lyapunov functionals. Finally, numerical simulations are presented to support our analytical results. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Using the Robson Classification to Explain the Fluctuations in Cesarean Section

alkiviadis.1961 shared this article with you from Inoreader Using the Robson Classification to Explain the Fluctuations in Cesarean Section Via Hindawi Publishing Corporation Purpose.tempspacetempspaceAs the rate of cesarean sections (CS) continues to rise in Flanders (northern part of Belgium), it is important to understand the reasons behind this evolution and to find ways to achieve appropriate CS rates.tempspacetempspaceFor this analysis, we categorized CS changes between 1992 and 2016, applying the Robson 10-Group Classification System (TGCS).tempspacetempspaceWe also applied the TGCS to analyze the information of the only clinics where between 2008 and 2016, the absolute CS rate had fallen by more than two percent.tempspacetempspaceMethods.tempspacetempspaceThis paper is based on a population-based cross-sectional study.tempspacetempspaceRobson's TGCS was used to analyze CS rates for the years 1992, 2000, 2008, and 2016, using the Flemish population-based birth register.temps pacetempspaceResults.tempspacetempspaceBetween 1992 and 2016, the overall CS rate increased from 11.8% in 1992 to 20.9% in 2016.tempspacetempspaceThe major contributors to that increase were (a) single, cephalic nulliparous women, at term in spontaneous labor (Robson group 1); (b) single, cephalic nulliparous women, at term in induced labor or CS before labor (group 2); and (c) multiparous women with single cephalic at term pregnancy with history of CS (group 5).tempspacetempspaceIn the subgroup of the seven clinics where the collective CS rate had decreased from 23.2% in 2008 to 19.3% in 2016, the main contributors to this decrease were Robson groups 1 and 2.tempspacetempspaceConclusions.tempspacetempspaceThe CS increase in Flanders between 1992 and 2016 is mainly the result of the absolute CS increase in the childbirth of nulliparous women with a single cephalic baby at term in spontaneous or induced labor and in women with a single cephalic presentation at term and a previous CS. tempspacetempspaceFurther research in these aforementioned groups is needed to identify the real reasons for the CS increase. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Maternal Deaths due to Obstetric Haemorrhage in Dodoma Regional Referral Hospital, Tanzania

alkiviadis.1961 shared this article with you from Inoreader Maternal Deaths due to Obstetric Haemorrhage in Dodoma Regional Referral Hospital, Tanzania Via Hindawi Publishing Corporation Background.tempspacetempspaceDespite the availability of comprehensive emergency obstetric care at Dodoma Regional Referral Hospital, deaths due to obstetric haemorrhage are still high.tempspacetempspaceThis study was carried out to analyse the circumstances that had caused these deaths.tempspacetempspaceMethods.tempspacetempspaceA retrospective review of all files of women who had died of obstetric haemorrhage from January 2018 to December 2019 was made.tempspacetempspaceResults.tempspacetempspaceA total of 18,296 women gave birth at DRRH; out of these, 61 died of pregnancy-related complications of the deceased while 23 (38%) died of haemorrhage, with many of them 10 (44%) between the age of 30 and 34.tempspacetempspaceMany were grand multiparous women 8 (35%) and almost half of them (11 (48%)) had stayed at DRRH for less than 24 hours.tempspacetempspaceMore than half (12 (52%)) had delivered by caesarean section followed by laparotomy due to ruptured uterus (8 (35%)).tempspacetempspaceThe leading contributing factors to the deaths of these women were late referral (6 (26%)), delays in managing postpartum haemorrhage due to uterine atony (4 (17%)), inadequate preparations in patients with the possibility of developing PPH (4 (17%)), and delay in performing caesarean section (3 (13%)).tempspacetempspaceConclusion.tempspacetempspaceMaternal mortality due to obstetric haemorrhage is high at Dodoma Regional Referral Hospital where more than one-third of women died between 2018 and 2019.tempspacetempspaceAlmost all of these deaths were avoidable.tempspacetempspaceThe leading contributing factors were late referral from other health facilities, inadequate skills in managing PPH due to uterine atony, delays in performing caesarean section at DRRH, and inadequate preparation for managing PPH i n patients with abruptio placentae and IUFD which are risk factors for the condition.tempspacetempspaceThere is a need of conducting supportive supervision, mentorship, and other modes of teaching programmes on the management of obstetric haemorrhage to health care workers of referring facilities as well as those at DRRH.tempspacetempspaceMonitoring of labour by using partograph and identifying pregnant women at risk should also be emphasized in order to avoid uterine rupture. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Can Mobile Technology Help Prevent the Burden of Dementia in Low- and Mid-Income Countries?

alkiviadis.1961 shared this article with you from Inoreader Can Mobile Technology Help Prevent the Burden of Dementia in Low- and Mid-Income Countries? Via Frontiers in Public Health | New and Recent Articles View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Lifetime Duration of Exposure to Biomechanical Factors at Work as a Mediator of the Relationship Between Socioeconomic Position and Walking Speed

alkiviadis.1961 shared this article with you from Inoreader Lifetime Duration of Exposure to Biomechanical Factors at Work as a Mediator of the Relationship Between Socioeconomic Position and Walking Speed Via Frontiers in Public Health | New and Recent Articles The study aimed to assess the proportion mediated by the duration of exposure to ergonomic factors at work on the relationship between socioeconomic position (SEP) and low walking speed. This cross-sectional study was performed on data collected at baseline on 19,704 men and 20,273 women 45–70 years old, currently or previously employed, enrolled in the Constances cohort. SEP was assigned through current or last occupation, categorized in three classes, based on the European Socioeconomic Classification. W alking speed was assessed through one measurement of normal walking for 3 m and dichotomized at the lowest quintile of the sex- and age- (5-year) specific distribution. Self-reported workplace exposure throughout working life to repetitive work, intense physical work, and lifting/carrying heavy loads was used to assess the duration of exposure to each factor, categorized in four classes. Through Poisson regression models, adjusted for BMI, smoking, alcohol intake, hypertension, physical activity, diabetes, cardiovascular diseases, and a cognitive score, the attenuation in the prevalence ratio (PR) of low walking speed by SEP produced by the inclusion of duration of exposure to each factor was evaluated. The mediating effect of work ergonomic exposures on the relationship between SEP and low walking speed was assessed using the weighted method by Vanderweele. In the fully adjusted model without ergonomic exposures, both men and women in the middle and the lowest SEP had a significant ly increased risk of low walking speed compared with those in the highest SEP (men: PR = 1.30 and PR = 1.46, respectively; women: PR = 1.24 and PR = 1.45, respectively). The inclusion in separate regression models of exposure duration to repetitive work, intense physical work, and handling of heavy loads produced modest risk attenuations in both men and women, all smaller or around 10%. Mediation analysis revealed in both sexes significant mediation effects for most ergonomic exposures considered, although also with low mediation effects. Significant differences in walking speed by SEP were observed in this large sample, but the proportion of such differences explained by the duration of exposure to ergonomic factors at work was low using either the risk attenuation or the mediation analysis methods. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.