Abstract
Background
Temporomandibular joint osteoarthritis is a common degenerative joint disease. This disease negatively affects the daily life, speech and chewing functions of patients.
Objective
This study aimed to evaluate the effects of intraarticular injection of alendronate to osteoarthritis, which has a protective effect on bone and cartilage tissue and helps reduce inflammation in temporomandibular joint osteoarthritis.
Methods
A total of 24 Wistar Albino rats were used in the study. Rats were divided into 4 groups as study, saline, control, and sham. In both saline and control groups, monosodium iodoacetate was injected intraarticularly to induce osteoarthritis. Alendronate was administered intraarticularly to the study group weekly for 4 weeks. In the saline group, saline was administered by intraarticular injection. At the end of the 12th week, all groups were sacrificed. Mandibular condyle tissues were examined histopathologically.
Results
According to the results, osteoarthritic changes in the control group were higher than those in the study group (p<0.05). No significant reduction in osteoarthritic changes was observed in the saline group (p>0.05). Significant osteoarthritis findings were observed in all groups compared to the sham group (p<0.05).
Conclusion
Intraarticular injection of alendronate was found to have positive results on TMJ osteoarthritis. In addition, it was seen that alendronate has effects on reducing cartilage tissue degeneration and loss of matrix proteins.
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