Wednesday, August 3, 2022

Clinical characteristics, outcomes, and seasonality of acute respiratory infection associated with single and co‐detected rhinovirus species among hospitalized children in Amman, Jordan

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Abstract

Background

Rhinovirus (RV)-specific surveillance studies in the Middle East are limited. Therefore, we aimed to study the clinical characteristics, outcomes, and seasonality of RV-associated acute respiratory infection among hospitalized young children in Jordan.

Methods

We conducted a prospective viral surveillance study and enrolled children <2 years old admitted to a large public hospital in Amman, Jordan (2010–2013). Demographic and clinical data were collected by structured interviews and chart abstractions. Nasal and/or throat swabs were collected and tested for a panel of respiratory viruses, and RV genotyping and speciation was performed.

Results

At least one virus was detected in 2,641/3,168 children (83.4%). RV was the second most common virus detected (n=1,238; 46.9%) and was co-detected with another respiratory virus in 730 cases (59.0%). Children with RV co-detection were more likely than those with RV-only detection to have respiratory distress but had similar outcomes. RV-A accounted for about half of RV-positive cases (54.7%), while children with RV-C had a higher frequency of wheezing and reactive airway disease. RV was detected year-round and peaked during winter.

Conclusions

Though children with RV co-detection had worse clinical findings, neither co-detection nor species affected most clinical outcomes.

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