miR-638 suppresses proliferation by negatively regulating high mobility group A1 in ovarian cancer cells

xlomafota13 shared this article with you from Inoreader miR-638 suppresses proliferation by negatively regulating high mobility group A1 in ovarian cancer cells Via Experimental and therapeutic medicine Exp Ther Med. 2021 Nov;22(5):1319. doi: 10.3892/etm.2021.10754. Epub 2021 Sep 20. ABSTRACT Ovarian cancer is one of the most common gynecological diseases with high mortality rates. Previous studies have shown that microRNA (miR)-638 is associated with tumorigenesis. The present study aimed to assess the role and underlying mechanisms of miR-638 in ovarian cancer. miR-638 expression was detected in ovarian cancer tissues and miR-638 was overexpressed or knocked down in ovarian cancer OVCAR-3 and Caov-3 cells. The clinical results revealed that miR-638 expression was downregulated in ovarian cancer tissues compared with in adjacent normal tissues. miR-638 expression was also found to be relatively low in OVCAR-3 cells whilst being relatively high in Caov-3 cells among the five ovarian cancer cell lines tested. miR-638 overexpression inhibited cell viability, arrested the cell cycle at the G1 phase and promoted apoptosis in OV CAR-3 cells. By contrast, miR-638 knockdown increased Caov-3 cell viability, facilitated cell cycle progression and inhibited apoptosis. miR-638 reduced the expression of high mobility group A1 (HMGA1) by directly targeting its 3' untranslated region. HMGA1 overexpression reversed the inhibition of proliferation induced by miR-638 overexpression in OVCAR-3 cells. These results suggest that miR-638 may serve to be a suppressor of ovarian cancer by regulating HMGA1, which may provide a potential therapeutic target for ovarian cancer. PMID:34630673 | PMC:PMC8495545 | DOI:10.3892/etm.2021.10754 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.