Identification of specific clinical risk factors associated with the malignant transformation of oral epithelial dysplasia

xlomafota13 shared this article with you from Inoreader Identification of specific clinical risk factors associated with the malignant transformation of oral epithelial dysplasia Via Head & Neck Abstract Background Factors that increase the risk of malignant transformation of oral epithelial dysplasia (OED) are not completely elucidated. Methods A retrospective chart review was performed assessing risk factors for transformation of OED, and cancer staging for transformed cases at Sunnybrook Health Sciences Centre. Results Two-hundred four patients were diagnosed with OED, and 16.7% (34) underwent malignant transformation. Risk factors associated with transformation included: heavy tobacco smoking, excessive EtOH consumption, non-homogenous leukoplakia, size >200 mm2, moderate dysplasia or greater than moderate, progression of dysplasia grades, and immunosuppression. Transformed cases followed for a dysplastic lesion were associated with a stage-I cancer diagnosis, and cancer cases with no prior biopsy were associated with a stage-IV diagnosis. Conclusions In addition to commonly cited risk factors, immunosuppression was associated with malignant transformation, including the use of topical steroids. Analyzing risk factors can help clinicians define risk of progression in patients with OED. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.