MicroRNA-934 promotes colorectal cancer cell proliferation by directly targeting Dickkopf-related protein 2

xlomafota13 shared this article with you from Inoreader MicroRNA-934 promotes colorectal cancer cell proliferation by directly targeting Dickkopf-related protein 2 Via Experimental and therapeutic medicine Exp Ther Med. 2021 Sep;22(3):1041. doi: 10.3892/etm.2021.10473. Epub 2021 Jul 21. ABSTRACT Increasing evidence demonstrates that dysregulation of microRNAs (miRNAs/miRs) is implicated in the development of colorectal cancer. However, the biological functions of several differentially expressed miRNAs remain unknown. In the present study, a bioinformatic analysis of a previously published microarray data and reverse transcription-quantitative PCR analysis demonstrated that miR-934 expression was upregulated in colorectal cancer samples collected from patients. Mechanistically, Dickkopf-related protein 2 (DDK2) was identified as a novel target gene of miR-934 in colorectal cancer cells. Knockdown of DDK2 reversed the inactivation of Wnt signaling pathway induced using miR-934 inhibitor in colorectal cancer cells. In addition, DDK2 silencing reversed miR-934 inhibitor-induced cell proliferation inhibition and elevation of cell apoptosis. The results demonstrated that DDK2 mRNA expression was negatively associated with miR-934 expression in colorectal tumors. Collectively, the results of the present study demonstrated that the miR-934/DDK2 axis regulated colorectal cancer cell proliferation, suggesting that miR-934 may be a biomarker for patients with colorectal cancer. PMID:34373727 | PMC:PMC8343583 | DOI:10.3892/etm.2021.10473 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.