J Vet Intern Med. 2021 Jun 6. doi: 10.1111/jvim.16185. Online ahead of print.
ABSTRACT
BACKGROUND: Injectable radioactive iodine (I-131) frequently is used to treat hyperthyroidism in cats. In human medicine, residual activity after injection of radionuclides has been reported, and the actual quantity administered is recorded after administration.
OBJECTIVE: Our aim was to evaluate actual administered dose variability after administration of preprepared I-131 single unit dose s for the treatment of hyperthyroidism in cats.
ANIMALS: Twenty-seven cats with hyperthyroidism treated with I-131 between April 2017 and March 2019.
METHODS: Retrospective observational study of cats treated with preprepared single unit I-131 doses. For each dose, the measured activity before administration and residual activity were recorded. The measured dose and the actual dose administered were compared to the prescribed dose.
RESULTS: Measured activity before administration ranged from 88.4% to 103.3% of the prescribed dose. Mean residual activity was 5.2 ± 3.0 MBq (ranging from 1.5% to 15% of the prescribed dose). The actual dose administered (measured activity - residual activity) ranged from 79.1% to 100.2% of the prescribed dose. Seventeen of 28 (60.7%) of the actual administered doses differed between 10% and 20% of the prescribed dose. One administered dose had a >20% difference compared to the prescribed dose (79.10% of the prescribed dose).
CONCLUSION AND CLINICAL IMPORTANCE: Our study identified variability in the residual and actual administered activity of I-131 as compared to the prescribed dose, which should be taken into consideration when treating cats with (predrawn) I-131.
PMID:34096090 | DOI:10.1111/jvim.16185
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