Melanoma is a highly heterogeneous tumor. The incidence of melanoma increases with age and its long-term prognosis is poor. The treatment of melanoma includes surgical removal, chemotherapy and immunotherapy; however, the effect of these treatments is limited on mutated melanoma. Osteopontin is an extrace llular protein which is expressed in numerous kinds of cells; it is related to the proliferation and invasion of cancer cells as well as the development of tumor microenvironment. The relationship between osteopontin and metastasis of melanoma has been clarified in recent years. This review focuses on the expression of osteopontin in patients with melanoma and associated signaling pathways involved in development and metastasis of melanoma; the potential role of osteopontin in immune modulation and prognosis prediction is also discussed here. Received 6 December 2020 Accepted 30 April 2021 Correspondence to Yun Zhao, MD, Department of Dermatology, General Hospital of the Yangtze River Shipping, Wuhan 430015, China, Tel: +86 18207196192; e-mail: 458459025@qq.com Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
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