Nomograms for predicting survival outcomes in intensity‐modulated radiotherapy era of nasopharyngeal carcinoma: A study based on Epstein–Barr virus DNA biological responses

xlomafota13 shared this article with you from Inoreader Nomograms for predicting survival outcomes in intensity‐modulated radiotherapy era of nasopharyngeal carcinoma: A study based on Epstein–Barr virus DNA biological responses Via Head & Neck Abstract Background Treatment of nasopharyngeal carcinoma (NPC) is evolving toward Intensity‐modulated radiotherapy (IMRT) era, which requires patient‐specific reestimation of survival outcomes in modern health care. Methods A total of 488 detectable pre‐treatment Epstein–Barr virus (EBV) DNA patients (stage II‐IVa) treated with induction chemotherapy (IC) and IMRT were examined (training set, n = 325; validation set, n = 163). Results Concurrent chemotherapy (CC) was still an independent prognosticator for overall survival (OS) and progression‐free survival (PFS). Both nomograms included age, T classification, N classification, post‐IC EBV DNA, and CC. Predictions correlated well with observed 3‐/5‐year OS and PFS. The concordance index was 0.776 (95% confidence interval (CI) 0.69–0.86) for OS and 0.742 (95% CI 0.65–0.83) for PFS in the validation cohort. The nomograms can successfully classify patients into low‐ and high‐risk groups. Conclusion The validated nomograms provided useful prediction of OS and PFS for detectable pre‐treatment EBV DNA patients with NPC in IMRT era. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.