Tuesday, January 12, 2021

Clinical and survival analysis of nasopharyngeal carcinoma with consistently negative Epstein–Barr virus DNA

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Abstract

Background

To assess the clinical and survival features of nasopharyngeal carcinoma (NPC) with consistently negative Epstein–Barr virus (EBV) DNA level.

Methods

Propensity score matching (PSM) method was used to create well‐balanced cohorts. Kaplan–Meier method and Cox proportional hazards models were performed to conduct survival analysis.

Results

Four hundred and eighty patients were enrolled. Patients with consistently negative plasma EBV DNA level had a greater chance to present a relatively earlier T and N classification compared with those with positive EBV DNA level (p < .001; p = .015). And patients with consistently negative EBV level were significantly associated with preferable 3‐year DFS (95.0% vs. 84.4%, p = .004), DMFS (98.3% vs. 89.4%, p = .009), and OS (100% vs. 97.6%, p = .004).

Conclusions

NPC patients with consistently negative EBV DNA level performed an earlier clinical stage and negative EBV DNA level was related to preferable survival outcomes.

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