Targeting telomeres: Molecular dynamics and free energy simulation of gold-carbene binding to DNA

payt.helady61 shared this article with you from Inoreader Targeting telomeres: Molecular dynamics and free energy simulation of gold-carbene binding to DNA Via Biophysical Journal DNA sequences in regulatory regions and in telomers at the ends of chromosomes frequently contain tandem repeats of guanine nucleotides that can form stacked structures stabilized by Hoogsten pairing and centrally bound monovalent cations. The replication and elongation of telomeres requires the disruption of these G-quadruplex structures. Hence, drug molecules such as gold(Au)-carbene that stabilize G-quadruplexes may also interfere with the elongation of telomeres and in turn could be used to control cell replication and growth. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.