Monday, November 30, 2020

A homozygous MPZL2 deletion is associated with non syndromic hearing loss in a moroccan family.

xloma.fota.13 shared this article with you from Inoreader
Related Articles

A homozygous MPZL2 deletion is associated with non syndromic hearing loss in a moroccan family.

Int J Pediatr Otorhinolaryngol. 2020 Nov 02;:110481

Authors: Amalou G, Bonnet C, Riahi Z, Bouzidi A, Elrharchi S, Bousfiha A, Charif M, Kandil M, Lenaers G, Petit C, Barakat A

Abstract
Adhesion glycoproteins are implicated in the pathophysiology of hearing loss, the most frequent inherited sensory disorder, affecting 1 in 1000 new-borns. Exome sequencing of a consanguineous Moroccan patient with mild hearing loss identified for the first time in a North African family a single homozygous mutation c.72delA in MPZL2 gene, encoding the Myelin Protein Zero-Like 2, reported as causing deafness in two other populations. Variable tandem repeat genotyping of this family revealed that the c.72delA MPZL2 allele shared a common haplotype with Turkish and Dutch families. These results confirm the pathogenicity of this MPZL2 mutation in recessive mild to moderate non-syndromic deafness.

PMID: 33234333 [PubMed - as supplied by publisher]

View on the web

No comments:

Post a Comment

Collaboration request

Hi there How would you like to earn a 35% commission for each sale for life by selling SEO services Every website owner requires the ...