Pharmacy, Vol. 8, Pages 191: Role of Pharmacists in Hormonal Contraceptive Access: A Survey of North Carolina Pharmacists: Pharmacy, Vol. 8, Pages 191: Role of Pharmacists in Hormonal Contraceptive Access: A Survey of North Carolina PharmacistsPharmacy doi: 10.3390/pharmacy8040191Authors: Gwen J Seamon Allison Burke Casey R Tak Amy Lenell Macary Weck Marciniak Mollie Ashe Scott The role of pharmacy in healthcare continues to evolve as pharmacists gain increased clinical responsibilities...
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JCM, Vol. 9, Pages 3318: Cystocele Repair by a Modified Surgical Technique of Bilateral Pubococcygeus Plication: Long-Term Surgical and Functional Results: JCM, Vol. 9, Pages 3318: Cystocele Repair by a Modified Surgical Technique of Bilateral Pubococcygeus Plication: Long-Term Surgical and Functional ResultsJournal of Clinical Medicine doi: 10.3390/jcm9103318Authors: Matteo Balzarro Emanuele Rubilotta Alessandro Antonelli Here we describe our modified surgical technique of bilateral pubococcygeus...
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Detection of Usutu virus infection in wild birds in the United Kingdom, 2020: In August 2020, as part of a long-term disease surveillance programme, Usutu virus was detected in five Eurasian blackbirds (Turdus merula) and one house sparrow (Passer domesticus) from Greater London, England. This was initially detected by reverse transcription-PCR and was confirmed by virus isolation and by immunohistochemical detection of flavivirus in tissues. Phylogenetic analysis identified Usutu virus African 3.2...
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Detection and discrimination of influenza B Victoria lineage deletion variant viruses by real-time RT-PCR: Background During the 2016/17 influenza season, influenza B/VIC lineage variant viruses emerged with two (K162N163) or three (K162N163D164) amino acid (aa) deletions in the haemagglutinin (HA) protein. There are currently five antigenically distinct HA proteins expressed by co-circulating influenza B viruses: B/YAM, B/VIC V1A (no deletion), B/VIC V1A-2DEL (2 aa deletion) and two antigenically...
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Molecular epidemiological typing of Neisseria gonorrhoeae isolates identifies a novel association between genogroup G10557 (G7072) and decreased susceptibility to cefixime, Germany, 2014 to 2017: Background Emerging antimicrobial resistance (AMR) challenges gonorrhoea treatment and requires surveillance.Aim This observational study describes the genetic diversity of Neisseria gonorrhoeae isolates in Germany from 2014 to 2017 and identifies N. gonorrhoeae multi-antigen sequence typing (NG-MAST)...
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Short-term outcomes after a neonatal arterial ischemic stroke: AbstractPurposeThe purpose of this study is to determine the frequency and radiological predictors of recurrent acute symptomatic seizures (RASS) and motor impairment at discharge after a neonatal arterial ischemic stroke (NAIS). MethodsIn a nonconcurrent cohort study, 33 full-term newborns with NAIS confirmed by MRI are admitted into our hospital between January 2003 and December 2012. Stroke size, calculated as...
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Down–regulating miR-217-5p Protects Cardiomyocytes against Ischemia/Reperfusion Injury by Restoring Mitochondrial Function via Targeting SIRT1: Abstract Downregulating miR-217-5p could protect cardiomyocytes against ischemia/reperfusion (I/R) injury, but its role in restoring mitochondrial function of I/R-injured cardiomyocytes remained unclear. H9C2 cardiomyocyte-derived cell line with I/R injury was established in vitro on the basis of hypoxia/reperfusion...
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Age- and movement-related modulation of cortical oscillations in a mouse model of presbycusis: Publication date: Available online 15 October 2020Source: Hearing ResearchAuthor(s): J.A. Rumschlag, J.W. Lovelace, K.A. RazakFigures (8)Show all figuresTables (3)Table 1Table 2Table 3Hearing ResearchAvailable online 15 October 2020, 108095In Press, Journal Pre-proofWhat are Journal Pre-proof articles?Age- and movement-related modulation of cortical oscillations in a mouse model of presbycusisAuthor links...
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Sialic acids expression in newborn rat lungs: implications for pulmonary developmental biology: Publication date: December 2020Source: Acta Histochemica, Volume 122, Issue 8Author(s): Maria de Fátima Martins, Ana Honório-Ferreira, Marco S. Reis, Catarina Cortez-Vaz, Carlos Alberto GonçalvesFigures (4)Tables (3)Table 1Table 2Table 3Acta HistochemicaVolume 122, Issue 8, December 2020, 151626Sialic acids expression in newborn rat lungs: implications for pulmonary developmental biologyAuthor links open...
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Penetrating Midface Trauma: A Case Report, Review of the Literature, and a Diagnostic and Management Protocol: Publication date: Available online 14 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Eric Holmgren, Derrek Schartz, Nithya Puttige Ramesh, Kimutai Sylvester, Clifford Eskeyigures (11)Show all figuresTables (3)Table 1Table 2Table 3Journal of Oral and Maxillofacial SurgeryAvailable online 14 October 2020In Press, Uncorrected ProofWhat are Uncorrected Proof articles?Craniomaxillofacial...
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Leukocyte and platelet-rich fibrin have same effect as blood clot in the three-dimensional alveolar ridge preservation. A split-mouth randomized clinical trial: Publication date: Available online 15 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Pedro Christian Aravena, Stephania Pilar Sandoval, Felipe Eduardo Pizarro, María Isabel Simpson, Nicolás Castro-Adams, Guillaume Serandour, Cristian Rosas
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Effect of adding androgen deprivation therapy to permanent iodine-125 implantation with or without external beam radiation therapy on the outcomes in patients with intermediate-risk prostate cancer: A propensity score–matched analysis<a name="bfn1" href="#fn1" aria-label="open footnote" id="crosref0010"><sup>1</sup></a>: Publication date: Available online 14 October 2020Source: BrachytherapyAuthor(s): Shinya Sutani, Atsunori Yorozu, Kazuhito Toya, Yutaka Shiraishi, Toru Nishiyama,...
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Comparison of outcomes using radiotherapy or brachytherapy after resection of primary adenoid cystic carcinoma in oral and maxillofacial regions: Publication date: Available online 14 October 2020Source: BrachytherapyAuthor(s): C. Li, S.M. Liu, L. Zheng, M.W. Huang, Y. Shi, X.M. Lv, J.G. Zhang, X. Peng, J. Zhang
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Identification of male infertility-related long non-coding RNAs and their functions based on a competing endogenous RNA network: Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo identify male infertility-related long non-coding (lnc)RNAs and an lncRNA-related competing endogenous (ce)RNA network.MethodsExpression data including 13 normospermic and eight teratozoospermic samples from postmortem donors were downloaded from the GEO database (GSE6872). The limma...
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Spontaneous remission of untreated primary amyloidosis of the bladder after transurethral resection biopsy: a case report and literature review: Journal of International Medical Research, Volume 48, Issue 10, October 2020. We herein present a case involving a 23-year-old woman with gross hematuria. Cystoscopy revealed abnormal areas of the mucosa along the anterior and posterior bladder walls. These abnormalities were suspicious for neoplasia; however, a diagnosis was not established by subsequent...
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Study on the related factors of post‐herpetic neuralgia in hospitalized patients with herpes zoster in Sichuan Hospital of Traditional Chinese Medicine based on big data analysis: AbstractBackgroundAlthough various factors were reported to be related to post‐herpetic neuralgia (PHN), studies based on adequate and comprehensive data were absent.MethodsData was extracted from cases of hospitalized patients with herpes zoster in dermatology department, Sichuan hospital of traditional Chinese medicine...
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Atypical Bilateral Multifocal Congenital Toxoplasmosis Retinochoroiditis: Case Report With Literature Review: Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. BackgroundToxoplasmosis gondii is ubiquitously present on earth and infection, including congenital infection, is common. Neurological, developmental, and ocular effects can be devastating in the congenital toxoplasmosis population. At present, there is no standard, nation-wide neonatal screening...
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Massive Upper Gastrointestinal Bleeding Following LAMS (Lumen-Apposing Metal Stent) Placement: Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Pancreatic pseudocyst is a common complication of pancreatitis. Pseudocysts may require decompression when they become painful, infected, or start compressing surrounding organs. Decompression is achieved by endoscopic cystogastrostomy. Recently, the use of lumen-apposing metal stent (LAMS) for cystogastrostomy...
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Subacute Aspergillosis "Fungal Balls" Complicating COVID-19: Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Severe acute respiratory syndrome coronavirus-2 infection (SARS-CoV-2), commonly known as COVID-19 (coronavirus disease-2019), began in the Wuhan District of Hubei Province, China. It is regarded as one of the worst pandemics, which has consumed both human lives and the world economy. COVID-19 infection mainly affects the lungs triggering...
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A Progressive Case of Eosinophilic Myocarditis Due to Eosinophilic Granulomatosis With Polyangiitis in a Caucasian Male: Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Vasculitis is an inflammatory process involving blood vessels of various sizes, including the small vessels in the kidneys to the large vessels, such as the aorta. This inflammatory condition is usually autoimmune in nature and is associated with involvement of many locations, such...
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Oxygen therapy strategies and techniques to treat hypoxia in COVID-19 patients: OBJECTIVE: Hypoxia is one of the primary causes that leads to multiple organ injuries and death in COVID-19 patients. Aggressive oxygen therapy for the treatment of hypoxia is important in saving these patients. We have summarized the mechanisms, efficacy, and side effects of various oxygen therapy techniques and their status or the potential to treat hypoxia in COVID-19 patients. The benefit to risk ratio of each oxygen...
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A Comparison of Conventionally Versus Digitally Fabricated Denture Outcomes in a University Dental Clinic: AbstractPurposeThe purpose of this retrospective, cross‐sectional study is to evaluate if there is a difference in number of visits (including fabrication and post‐operative) and remake rate when comparing conventionally fabricated and digitally fabricated complete dentures by dental students in a pre‐doctoral student dental clinic.Materials and MethodsThis two‐year retrospective cross‐sectional...
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Lectin Drug Conjugate Therapy for Colorectal Cancer: AbstractDrug resistance represents an obstacle in colorectal cancer treatment because of its association with poor prognoses. rBC2LCN is a lectin isolated from Burkholderia that binds cell surface glycans that have fucose moieties. Since fucosylation is often enhanced in many types of cancers, this lectin could be an efficient drug carrier if colorectal cancer cells specifically present such glycans. Therefore, we examined the therapeutic efficacy...
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What causes hidradenitis suppurativa ? – 15 years after: AbstractThe 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30–April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote "Hopefully, this heralds a welcome new tradition: to get to the molecular heart of HS pathogenesis, which can only be achieved...
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Genome‐wide association analysis of psoriasis patients treated with anti‐TNF drugs: AbstractBackgroundWhile anti‐TNF therapies are effective against psoriasis, 30‐50% of patients do not show an adequate response to these drugs. Different candidate‐gene pharmacogenetics studies have identified single nucleotide polymorphisms that may predict anti‐TNF drugs response in psoriasis. Nevertheless, only one paper has undertaken a pharmacogenomic approach failing to find significant biomarkers of biological...
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An active endoscope with small sweep volume that preserves image orientation for arthroscopic surgery: AbstractBackgroundMicrosurgery is generally performed in narrow spaces with limited movement. Endoscopes that allow for angle changes have been developed using elastic materials, but they require a large bending space. We propose a new endoscope with a small sweep volume for angle changes.MethodsWe fabricated a prototype with a thumb‐operated joystick. The image sensor is attached to the tooltip....
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Emergency Airway Management During Awake Craniotomy: Comparison of 5 Techniques in a Cadaveric Model: Background: During awake craniotomy, securing the patient's airway might be necessary electively or emergently. The objective of this study was to compare the feasibility of airway management using a laryngeal mask airway (LMA) and 4 alternative airway management techniques in an awake craniotomy simulation. Methods: After completing a questionnaire, 9 anesthesia providers attempted airway...
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Electroencephalographic Alpha and Delta Oscillation Dynamics in Response to Increasing Doses of Propofol: Background: The electroencephalogram (EEG) may be useful for monitoring anesthetic depth and avoiding overdose. We aimed to characterize EEG-recorded brain oscillations during increasing depth of anesthesia in a real-life surgical scenario. We hypothesized that alpha power and coherency will diminish as propofol dose increases between loss of consciousness (LOC) and an EEG burst suppression...
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Role of Dexmedetomidine in Aneurysmal Subarachnoid Hemorrhage: A Comprehensive Scoping Review: Dexmedetomidine (DEX), an α2-adrenergic agonist, has been widely used for anesthesia, pain control, and intensive care unit sedation. Besides sleep-like sedation, DEX has many other beneficial effects, such as anti-inflammation, antioxidation, and anticell death. Subarachnoid hemorrhage (SAH), a severe and potentially fatal form of stroke, is a complex disease that is divided into 2 phases: early brain...
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A Curious Case of Persistent Throat Pain: This case report describes a man in his 20s who presented with persistent, severe, right-sided, throbbing throat pain and dysphagia and was found to have bony mass in the parapharyngeal space following a tonsillectomy.
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A Cost-effective Solution to Limit Aerosol Transmission of Infectious Agents During Mastoid Drilling: To the Editor We were interested by the recent article by Carron, et al "A Simple Technique for Droplet Control During Mastoid Surgery" because we have also been considering the challenges of performing mastoidectomy in the coronavirus disease 2019 era. Mastoidectomy is an aerosol-generating procedure (AGP) owing to the use of drills and presence of potentially virus-containing respiratory mucosa...
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Facial Nerve Intraneural Perineurioma Masquerading as a Schwannoma: This case report describes a woman in her 30s who presented with worsening left-sided facial weakness and was diagnosed with a perineurioma.
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Atypical Presentation of Langerhans Cell Histiocytosis of the Skull: This case report describes a man in his 20s who presented with a 4-week history of progressive swelling of the midline forehead, recurrent headache, and sinus pain, and was subsequently diagnosed with Langerhans cell histiocytosis.
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Eustachian Tube Rhabdomyomatous Mesenchymal Hamartoma in a Pediatric Patient: This case report describes a young girl who presented with a history of chronic, unilateral middle ear effusion that was treated with a pressure equalization tube.
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Predictors of OSA following Adenotonsillectomy in Children with Trisomy 21: AbstractObjectivesGiven that 30‐50% of children with trisomy 21 have persistent obstructive sleep apnea (OSA) after adenotonsillectomy, we evaluated whether demographic, clinical and polysomnographic factors predicted persistent OSA and OSA severity after adenotonsillectomy.DesignRetrospective study.SettingSecondary care hospital.ParticipantsRetrospective review of 32 children with the diagnosis of trisomy 21 and OSA by polysomnography...
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Evaluation of cerebral arteriovenous shunts: a comparison of parallel imaging time-of-flight magnetic resonance angiography (TOF-MRA) and compressed sensing TOF-MRA to digital subtraction angiography: AbstractPurposeTime-of-flight (TOF)-MR angiography (MRA) is an important imaging sequence for the surveillance and analysis of cerebral arteriovenous shunt (AVS), including arteriovenous malformation (AVM) and arteriovenous fistula (AVF). However, this technique has the disadvantage of a relatively...
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Activation of 5‐HT7 receptor but not NOS is necessary for chronic 5‐HT‐induced hypotension: New FindingsWhat is the central question of this study? What mechanisms account for the hypotension observed during chronic elevations in circulating 5‐hydroxytryptamine in rats? What is the main finding and its importance? Chronic 5‐hydroxytryptamine induced hypotension requires continued activation of the 5‐HT7 receptor subtype but does not require NO, an outcome that resolves previous conflicting...
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Sleep restriction alters physiological and emotional responses to emotion induction: New FindingsThe aim of the present study was to assess the effects of sleep restriction on self report and autonomic responses to neutral and sad film clips. Ratings of sadness and heart rate deceleration were greater while watching the sad clip, with no effect of sleep restriction; whereas heart rate variability and skin conductance were impacted by sleep restriction and to a lesser extent by film clips. Results...
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The acute effect of resistance exercise on limb blood flow: New FindingsWhat is the central question of this study? How does resistance exercise affect peripheral haemodynamics in the active and inactive limb? What is the main finding and its importance? Preliminary data indicate that resistance exercise increases flow and shear rate in the active limb transiently. The same exercise has minimal, short‐lasting influence on peripheral haemodynamics in the inactive limb, but further research is...
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Optimising sleep and performance during night float: A systematic review of evidence and implications for graduate medical education trainees: AbstractGraduate medical education (GME) training commonly requires residents and fellows to engage in night float shift work. This review aims to assess the effectiveness of interventions for trainees when preparing for, completing, and recovering from working night float shifts. We reviewed all available studies published prior to September 2019 using PubMed,...
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A case series of intestinal obstruction secondary to shiitake mushroom intake during Chinese New Year: AbstractShiitake mushroom is a common ingredient in East Asian cuisines. Food processing/preparation can cause the mushroom to be soft and slimy, leading to accidental swallowing. Due to its high insoluble fibre content, it remains the same size and shape in the intestinal tract. We present two cases of small bowel obstruction caused by shiitake mushroom requiring surgical intervention. Preoperative...
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Ankylosis of the temporomandibular joint—impression free CAD/CAM based joint replacement using patient-specific implants: AbstractIn recent years, alloplastic temporomandibular joint (TMJ) replacement has become a permissible procedure for the reconstruction of severely destroyed TMJs. The use of computer-aided design/computer-aided manufacturing (CAD/CAM) has extended the range of applications to complex anatomical situations. The aim of the treatment is to improve the usually restricted mouth opening...
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Effect of chitosan solutions with or without fluoride on the protection against dentin erosion in vitro: The aim of this study was to assess the protective effect of experimental solutions containing chitosan at different viscosities with or without fluoride (TiF4/NaF) on dentin loss in vitro. Bovine dentin samples (n = 15) were prepared and allocated to one of the following treatments: (i) 0.5% chitosan (500 mPas); (ii) 0.5% chitosan (2,000 mPas); (iii) 0.042% NaF and 0.049% TiF4; (iv) as (iii)...
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Rosai‐Dorfman disease of the pancreas: Cytologic analysis of three cases presenting as pancreatic masses: AbstractRosai‐Dorfman Disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a rare entity characterized by proliferating S100‐positive histiocytes. It is most commonly found in lymph nodes with extranodal involvement usually occurring in the head and neck. Pancreatic involvement is extremely rare. The pathology department archives were searched for fine needle aspirations and...
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Epilepsy and movement disorders in CDG: Report on the oldest‐known MOGS‐CDG patient: AbstractCongenital glycosylation disorders (CDG) are inherited metabolic diseases due to defective glycoprotein and glycolipid glycan assembly and attachment. MOGS‐CDG is a rare disorder with seven patients from five families reported worldwide. We report on a 19‐year‐old girl with MOGS‐CDG. At birth she presented facial dysmorphism, marked hypotonia, and drug‐resistant tonic seizures. In the following months, her...
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Novel GLI3 pathogenic variants in complex pre‐ and postaxial polysyndactyly and Greig cephalopolysyndactyly syndrome: AbstractPolydactyly is a limb malformation and can occur as nonsyndromic polydactyly, syndromic polydactyly, or along with other limb defects. A few genes have been identified that cause various forms of syndromic and nonsyndromic polydactyly, of which GLI3 has been extensively explored. In the present study, GLI3 gene was screened by direct resequencing in 15 polydactyly cases with...
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Multiple Cranial Neuropathies as the Presenting Sign in a Patient with Metastatic BRAF-Mutated Lung Adenocarcinoma with Leptomeningeal Involvement: Leptomeningeal carcinomatosis accounts for only 4% of cases of multiple cranial neuropathies. Here, we report the case of a patient who presented with multiple synchronous cranial neuropathies. After treatment for neuroborreliosis and broad infectious workup, endobronchial ultrasound-guided mediastinal lymph node biopsy confirmed a diagnosis of metastatic...
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RT-qPCR versus Digital PCR: How Do They Impact Differently on Clinical Management of Chronic Myeloid Leukemia Patients?: Real-time quantitative PCR (RT-qPCR) is the gold standard to quantify the BCR-ABL1 transcript for molecular response monitoring in chronic myeloid leukemia (CML) patients, and it plays a pivotal role in clinical decision-making process, even if it presents technical limits. Increasing data suggest that digital PCR (dPCR) is more accurate and reliable than RT-qPCR in CML minimal...
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Acquired Pure Red Cell Aplasia Associated with Chronic Myelomonocytic Leukemia: Too Many of One, Not Enough of the Other: There is a growing body of literature outlining the association between certain hematological malignancies, such as chronic myelomonocytic leukemia (CMML), and systemic autoimmune diseases. Diagnosis and management can be difficult, particularly when autoimmune phenomena overlap with features of the underlying illness. This is especially the case in patients who develop immune-mediated...
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Microsatellite-Stable Radiation-Induced Angiosarcoma after Breast-Conserving Surgery: A Case Report: Radiation-induced angiosarcoma (RIAS) after breast-conserving surgery is quite rare. Risk factors for RIAS have yet to be identified, due largely to the very low incidence of this disease. The etiologic mechanisms of RIAS are not understood, although some reports suggest that genome instability may contribute to RIAS development. An 81-year-old Japanese woman presented to our hospital after developing...
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Associations of Objectively Measured Physical Activity and Sedentary Time with the Risk of Stroke, Myocardial Infarction or All-Cause Mortality in 70-Year-Old Men and Women: A Prospective Cohort Study: AbstractObjectiveTo study the associations of objectively measured physical activity (PA) and sedentary time (ST) with the combined outcome of incident stroke, myocardial infarction (MI) or all-cause mortality in older adults. MethodsN = 3343 men and women aged 70 who participated...
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Association among serum and salivary A. actinomycetemcomitans specific immunoglobulin antibodies and periodontitis: AbstractBackgroundThe aim of this study was to assess the association between serum and salivary Immunoglobulin (Ig) Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) specific antibodies in healthy controls (HC) and periodontitis (PT) patients. Furthermore, the objectives were to determine whether PT influenced serum A. actinomycetemcomitans specific antibodies and whether...
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Rates of lymphocytic thyroiditis and ultrasound features of citologically-interrogated thyroid nodules based on the area of residence in a Sicily province: AbstractPurposeTo verify the prevalence of autoimmune thyroiditis (AIT) and the ultrasound characteristics (composition and volume) of thyroid nodules with respect to the area of residence in the province of Messina, some areas having environmental issues. MethodsFine-needle aspiration-interrogated nodules (n = 902) of 809...
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The ketogenic diet corrects metabolic hypogonadism and preserves pancreatic ß-cell function in overweight/obese men: a single-arm uncontrolled study: AbstractBackgroundOverweight and obesity are increasingly spread in our society. Low testosterone levels are often present in these patients, the so-called metabolic hypogonadism, that further alters the metabolic balance in a sort of vicious cycle. Very low-calorie ketogenic diet (VLCKD) has been reported to efficiently reduce body weight, glycaemia,...
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The effect of dual-release versus conventional hydrocortisone on fatigue, measured by ecological momentary assessments: AbstractPurposeReplicating the physiological cortisol secretion is key in the treatment of glucocorticoid insufficient individuals and optimization may enhance quality of life. The study investigates fatigue measured by ecological momentary assessments in patients treated with conventional hydrocortisone compared with once-daily dual-release hydrocortisone (Plenadren). ...
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Vancomycin-Induced Linear IgA Bullous Dermatosis:
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Two Cases With Features of Lymphocyte Variant Hypereosinophilic Syndrome With STAT3 SH2 Domain Mutations: Lymphocyte variant hypereosinophilic syndrome (LV-HES) is a rare cause of eosinophilia that is due to eosinophilipoietic cytokine production by an immunophenotypically abnormal T-cell clone. The molecular pathogenesis of this disorder is largely unknown and only 1 case of LV-HES with a pathogenic STAT3 mutation has been described thus far. Here we report 2 cases of LV-HES with STAT3 SH2 domain...
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Mural Intracholecystic Neoplasms Arising in Adenomyomatous Nodules of the Gallbladder: An Analysis of 19 Examples of a Clinicopathologically Distinct Entity: Intracholecystic neoplasms (ICNs) (pyloric gland adenomas and intracholecystic papillary neoplasms, collectively also called intracholecystic papillary/tubular neoplasms) form multifocal, extensive proliferations on the gallbladder mucosa and have a high propensity for invasion (>50%). In this study, 19 examples of a poorly characterized...
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CT and FDG-PET radiologic biomarkers in p16+ oropharyngeal squamous cell carcinoma patients treated with definitive chemoradiotherapy: Survival among patients with human papilloma virus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is superior to those with non-HPV-associated OPSCC [1–3]. This is reflected in the most recent staging system, in which HPV-associated OPSCC is considered as a separate entity with unique TNM staging among head and neck cancers [4,5]. Although the standard...
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Intrathoracic migration of ventriculo-peritoneal shunt via Morgagni hernia: AbstractWe present the case of a 5-month-old patient presenting with pleural migration of ventriculo-peritoneal shunt catheter who returned 2 months later with respiratory distress. Ultimately, the diagnosis of a Morgagni hernia was made. This diagnosis, though rare, should be entertained in certain clinical settings.
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Application of 4D-CT Scanning in Differential Diagnosis of Arytenoid Subluxation and Vocal Fold Paralysis: To differentiate arytenoid subluxation and vocal fold paralysis by CT cine mode scanning combined with three-dimensional (3D) reconstruction image.
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Saponin from Periploca forrestii Schltr Mitigates Oxazolone-Induced Atopic Dermatitis via Modulating Macrophage Activation: Atopic dermatitis (AD) is a relapsing, acute, and chronic skin disease featured by intractable itching, eczematous skin. Conventional therapies based on immunosuppression such as corticosteroids are associated with multiple adverse reactions. Periploca forrestii Schltr saponin (PFS) was shown to potently inhibit murine arthritis by protecting bone and cartilage injury and suppressing...
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Real-Life Data on the Efficacy of Canakinumab in Patients with Adult-Onset Still's Disease: Background. Interleukin-1 inhibition has revealed to be a successful treatment approach for patients with adult-onset Still's disease (AOSD). However, real-life experience is focused on the use of anakinra, while data about canakinumab (CAN) are mainly based on case reports and small case series. Patients and Methods. Patients classified with AOSD according to Yamaguchi criteria and treated with CAN were consecutively...
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Surgical clip occlusion of the V3 segment to prevent recurrent cerebral infarction associated with extracranial vertebral artery dissection: A case report: Surgical clip occlusion of the V3 segment to prevent recurrent cerebral infarction associated with extracranial vertebral artery dissection: A case report Category: Article Type: Ryo Aiura, Masaki Matsumoto, Tohru Mizutani, Tatsuya Sugiyama, Daisuke TaniokaDepartment of Neurosurgery, Showa University Hospital, Tokyo,...
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Successful non-operative management for atlanto-occipital dislocation resulting in spinal cord contusion in a patient with atlanto-occipital assimilation and severe Chiari I malformation: Successful non-operative management for atlanto-occipital dislocation resulting in spinal cord contusion in a patient with atlanto-occipital assimilation and severe Chiari I malformation Category: Article Type: Jordan R. Davis1, Matthew L. Kluckman1, Grant W. Mallory2, John L. Ritter1Departments...
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Biopsychosocial variations in quality of life outcome following microdiscectomy: Biopsychosocial variations in quality of life outcome following microdiscectomy Category: Article Type: Lena Mary Houlihan, James Meeke, Orla Dunlea, Michael G. J. O'Sullivan, Chris Lim, George KaarDepartment of Neurosurgery, Cork University Hospital, Cork, Ireland.DOI:10.25259/SNI_449_2020Copyright: © 2020 Surgical Neurology International This is an open-access article distributed under the...
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Primary Ewing's sarcoma of the C2 vertebra with progressive quadriparesis: Report of a rare case and review of the literature: Primary Ewing's sarcoma of the C2 vertebra with progressive quadriparesis: Report of a rare case and review of the literature Category: Article Type: Anandkumar Khatavi, Charanjit Singh Dhillon, Nilay Chhasatia, Chetan Pophale, Shafeek Nanakkal, Amit VarshneyDepartment of Spine, MIOT Hospital, Chennai, Tamil Nadu, India.DOI:10.25259/SNI_497_2020Copyright:...
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Prevalence of intracranial aneurysms among acute ischemic stroke patients: Prevalence of intracranial aneurysms among acute ischemic stroke patients Category: Article Type: Jiroje Jiranukool1, Peeraphong Thiarawat1, Waneerat Galassi2Department of Neurosurgery, Naresuan University, Phitsanulok, Thailand.Department of Radiology, Naresuan University, Phitsanulok, Thailand.Correspondence Address:Jiroje JiranukoolDepartment of Radiology, Naresuan University, Phitsanulok, Thailand.DOI:10.25259/SNI_506_2020Copyright:...
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Histopathological variation in the demyelinating sentinel lesion of primary central nervous system lymphoma: Histopathological variation in the demyelinating sentinel lesion of primary central nervous system lymphoma Category: Article Type: Madan Bajagain1, Tatsuki Oyoshi1, Tomoko Hanada1, Nayuta Higa1, Tsubasa Hiraki2, Kiyohisa Kamimura3, Shinichi Kuroki1, Koji Yoshimoto1Departments of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University,...
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Surgical management of vertebral metastatic gastrointestinal stromal tumor: Case illustration, literature review, and pooled analysis: Surgical management of vertebral metastatic gastrointestinal stromal tumor: Case illustration, literature review, and pooled analysis Category: Article Type: Yu Tung Lo, David Siu Kei Mak, Colum Patrick NolanDepartment of Neurosurgery, National Neuroscience Institute, Singapore.DOI:10.25259/SNI_485_2020Copyright: © 2020 Surgical Neurology...
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Radionuclide tumor necrosis factor-alpha activity in herniated lumbar disc correlates with severe leg pain: Radionuclide tumor necrosis factor-alpha activity in herniated lumbar disc correlates with severe leg pain Category: Article Type: Pablo Andrade1, Jasper van Aalst2, Matthias Bauwens3, Andreas Vogg4, Marinus J. van Kroonenburgh3, Felix M. Mottaghy3,4, Onno P. Teernstra2, Govert Hoogland2,5Department of Stereotactic and Functional Neurosurgery, University Hospital...
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Successful mechanical thrombectomy using a combined technique for internal carotid artery occlusion with persistent primitive trigeminal artery: Successful mechanical thrombectomy using a combined technique for internal carotid artery occlusion with persistent primitive trigeminal artery Category: Article Type: Yoshinobu Horio1, Kenji Fukuda2, Takaya Yoshinaga1, Ryuhei Takeyama1, Hironori Fukumoto1, Kiminori Sato1, Yoshihisa Kawano1, Tooru Inoue2Department of Neurosurgery,...
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Endoscopic-assisted paramedian infratentorial supracerebellar approach for pineal cyst – How I do it Video clip: Endoscopic-assisted paramedian infratentorial supracerebellar approach for pineal cyst – How I do it Video clip Category: Article Type: Riki Tanaka1, Kazuhito Takeuchi2, Ahmed Ansari3, Kento Sasaki1, Kyosuke Miyatani1, Yasuhiro Yamada1, Tsukasa Kawase1, Yoko Kato1, Akihiko Horiguchi4Department of Neurosurgery, Fujita Health University Banbuntane Hospital,Department...
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The Latest on Uveal Melanoma Research and Clinical Trials: Updates from the Cure Ocular Melanoma (CURE OM) Science Meeting (2019): Uveal melanoma (UM) is a rare cancer in adults but its treatment is one of the clinical unmet needs in the melanoma field. Metastatic disease develops in approximately 50% of patients and is associated with poor survival due to the lack of effective treatment options. It provides a paradigm for cancers that show evidence of aberrant G-protein coupled receptor signaling,...
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Hypo-fractionated FLASH-RT as an effective treatment against glioblastoma that reduces neurocognitive side effects in mice: Purpose: Recent data has shown that single fraction irradiation delivered to the whole brain in less than tenths of a second using FLASH radiation therapy (RT), does not elicit neurocognitive deficits in mice. This observation has important clinical implications for the management of invasive and treatment-resistant brain tumors that involves relatively large irradiation volumes...
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Comparison of Dynamic Contrast-Enhancement Parameters between Gadobutrol and Gadoterate Meglumine in Posttreatment Glioma: A Prospective Intraindividual Study [FUNCTIONAL]: BACKGROUND AND PURPOSE:Differences in molecular properties between one-molar and half-molar gadolinium-based contrast agents are thought to affect parameters obtained from dynamic contrast-enhanced imaging. The aim of our study was to investigate differences in dynamic contrast-enhanced parameters between one-molar nonionic gadobutrol...
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Centrally Reduced Diffusion Sign for Differentiation between Treatment-Related Lesions and Glioma Progression: A Validation Study [ADULT BRAIN]: BACKGROUND AND PURPOSE:Differentiating between treatment-related lesions and tumor progression remains one of the greatest dilemmas in neuro-oncology. Diffusion MR imaging characteristics may provide useful information to help make this distinction. The aim of the study was to assess the diagnostic accuracy of the centrally reduced diffusion sign for differentiation...
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Location-Specific ASPECTS Paradigm in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis [ADULT BRAIN]: BACKGROUND:Weighting neuroimaging findings based on eloquence can improve the predictive value of ASPECTS, possibly aiding in informed treatment decisions for acute ischemic stroke.PURPOSE:Our aim was to study the contribution of region-specific ASPECTS infarction to acute ischemic stroke outcomes.DATA SOURCES:We searched MEDLINE and EMBASE for reports on ASPECTS in patients with acute...
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Image-Guided Biopsies in the Head and Neck: Practical Value and Approach [COMMENTARIES]:
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MRI-Based Assessment of the Pharyngeal Constrictor Muscle as a Predictor of Surgical Margin after Transoral Robotic Surgery in HPV-Positive Tonsillar Cancer [HEAD & NECK]: BACKGROUND AND PURPOSE:Transoral robotic surgery is an emerging strategy for treating human papillomavirus–positive cancers, but the role of MR imaging in predicting the surgical outcome has not been established. We aimed to identify preoperative MR imaging characteristics that predispose the outcome of transoral robotic surgery...
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125I seeds irradiation inhibits tumor growth and induces apoptosis by Ki-67, P21, survivin, livin and caspase-9 expression in lung carcinoma xenografts: Lung cancer is a fatal disease and a serious health problem worldwide. Patients are usually diagnosed at an advanced stage, and the effectiveness of chemotherapy for such patients is very limited. Iodine 125 s...
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Cranial Nerve III Palsy in the setting of COVID 19 Infection: No abstract available
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TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma: Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outco...
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Preclinical evaluation of 5-methyltetrahydrofolate-based radioconjugates—new perspectives for folate receptor–targeted radionuclide therapy: AbstractPurposeThe folate receptor (FR) is frequently overexpressed in a variety of tumor types and, hence, an interesting target for radionuclide therapy. The aim of this study was to evaluate a new class of albumin-binding radioconjugates comprising 5-methyltetrahydrofolate (5-MTHF) as a targeting agent and to compare their properties with those of the previously...
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Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities: SummaryLactoferrin has gained extensive attention due to its ample biological properties. In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins...
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Donafenib in Progressive Locally Advanced or Metastatic Radioactive Iodine-Refractory Differentiated Thyroid Cancer: Results of a Randomized, Multicenter Phase II Trial: Thyroid, Ahead of Print.
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Transcription Factor Profiling Identifies Spatially Heterogenous Mediators of Follicular Thyroid Cancer Invasion: AbstractWhile minimally invasive follicular thyroid cancer (miFTC) generally has low risk of recurrence or death, encapsulated angioinvasive (eaFTC) or widely invasive (wiFTC) histological subtypes display significantly worse prognosis. Drivers of invasion are incompletely understood. Therefore, tissue samples including miFTC, eaFTC, and wiFTC tumors, as well as histologically normal...
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Differential effects of GABA A receptor activation in the prelimbic and orbitofrontal cortices on anxiety: AbstractRationaleThe development of effective anxiety treatments has been hindered by limited understanding of the neurobiological mechanisms involved in anxiety regulation. Whilst gamma-aminobutyric acid (GABA) neurotransmission in the prefrontal cortex (PFC) is one mechanism consistently implicated in anxiety regulation, PFC subregions may contribute uniquely. ObjectivesThe...
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Urothelial toxicity of esketamine in the treatment of depression: AbstractRationaleKetamine is the first widely used substance with rapid-onset antidepressant action. However, there are uncertainties regarding its potential urothelial toxicity, particularly after repeated application. In the context of rising recreational ketamine use, severe side effects affecting the human urinary tract have been reported. It is assumed that ketamine interacts with bladder urothelial cells and induces apoptosis....
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ScienceDirect Publication: TalantaGraphite-polystyrene composite with enhanced electrochemical and electroanalytical performancePublication date: Available online 15 October 2020Source: TalantaAuthor(s): Andrei M. Surkov, Rodrigo G. Queiroz, Rafael S. Rinco, Alejandro G. Rios Ivano G. R. Gutz, Alexandre L.B. Baccaro, Lúcio AngnesScienceDirect Publication: TalantaThu Oct 15, 2020 13:18Ionic-liquid doped polymeric composite as passive colorimetric sensor for meat freshness as a use casePublication...
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BrachytherapyComparison of outcomes using radiotherapy or brachytherapy after resection of primary adenoid cystic carcinoma in oral and maxillofacial regionsPublication date: Available online 14 October 2020Source: BrachytherapyAuthor(s): C. Li, S.M. Liu, L. Zheng, M.W. Huang, Y. Shi, X.M. Lv, J.G. Zhang, X. Peng, J. ZhangBrachytherapyThu Oct 15, 2020 17:32Effect of adding androgen deprivation therapy to permanent iodine-125 implantation with or without external beam radiation therapy on the outcomes...
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Climate change likely drove early human species to extinction, modeling study suggestsOf the six or more different species of early humans, all belonging to the genus Homo, only we Homo sapiens have managed to survive. Now, a study combining climate modeling and the fossil record in search of clues to what led to all those earlier extinctions suggests that climate change -- the inability to adapt to either warming or cooling temperatures -- likely played a major role in sealing their fate.Evolutionary...
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bioRxiv Subject Collection: Evolutionary BiologySelfing is the safest sex for Caenorhabditis tropicalis [NEW RESULTS]Mating systems have profound effects on genetic diversity and compatibility. The convergent evolution of self-fertilization in three Caenorhabditis species provides a powerful lens to examine causes and consequences of mating system transitions. Among the selfers, C. tropicalis is the least genetically diverse and most afflicted by outbreeding depression. We generated a chromosomal-scale...
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NanomaterialsNanomaterials, Vol. 10, Pages 2038: Comparative Study of Nanostructured CuSe Semiconductor Synthesized in a Planetary and Vibratory MillNanomaterials, Vol. 10, Pages 2038: Comparative Study of Nanostructured CuSe Semiconductor Synthesized in a Planetary and Vibratory Mill Nanomaterials doi: 10.3390/nano10102038 Authors: Marcela Achimovičová Matej Baláž Vladimír Girman Juraj Kurimský Jaroslav Briančin Erika Dutková Katarína Gáborová Copper(II) selenide, CuSe was prepared from Cu and...
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International Journal of Molecular SciencesIJMS, Vol. 21, Pages 7642: Antineoplastic Activity of Chrysin against Human Hepatocellular Carcinoma: New Insight on GPC3/SULF2 Axis and lncRNA-AF085935 ExpressionIJMS, Vol. 21, Pages 7642: Antineoplastic Activity of Chrysin against Human Hepatocellular Carcinoma: New Insight on GPC3/SULF2 Axis and lncRNA-AF085935 Expression International Journal of Molecular Sciences doi: 10.3390/ijms21207642 Authors: Iman O. Sherif Laila A. Al-Mutabagani Dina Sabry Nehal...
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International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 7498: ICT-Enabled Mobile Work: Challenges and Opportunities for Occupational Health and Safety SystemsIJERPH, Vol. 17, Pages 7498: ICT-Enabled Mobile Work: Challenges and Opportunities for Occupational Health and Safety Systems International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207498 Authors: Robelski Sommer The development and dissemination of new technologies has brought...
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AntibioticsAntibiotics, Vol. 9, Pages 701: Antibiogram Profiles and Risk Factors for Multidrug Resistance of Salmonella enterica Recovered from Village Chickens (Gallus gallus domesticus Linnaeus) and Other Environmental Sources in the Central and Southern Peninsular MalaysiaAntibiotics, Vol. 9, Pages 701: Antibiogram Profiles and Risk Factors for Multidrug Resistance of Salmonella enterica Recovered from Village Chickens (Gallus gallus domesticus Linnaeus) and Other Environmental Sources in the...
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