Monday, September 14, 2020

Medicine by Alexandros G. Sfakianakis

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Associated analysis of PER1/TUBB2B with endometrial cancer development caused by circadian rhythm disorders: AbstractEndometrial cancer (EC) is one of the most common gynecologic malignancies, and the incidence rate of night shift among women workers is higher than that in the general population. Circadian rhythm disorder, mainly rhythm gene, is related to various tumor onset, including EC. This study described the sleep/night-shift features of EC patients, explored the mechanism of the circadian...
Nintedanib and a bi-specific anti-VEGF/Ang2 nanobody selectively prevent brain metastases of lung adenocarcinoma cells.: Nintedanib and a bi-specific anti-VEGF/Ang2 nanobody selectively prevent brain metastases of lung adenocarcinoma cells.Clin Exp Metastasis. 2020 Sep 12;:Authors: Kovalchuk B, Berghoff AS, Karreman MA, Frey K, Piechutta M, Fischer M, Grosch J, Heiland S, Breckwoldt MO, Hilberg F, Wick W, Winkler FAbstract Brain metastases (BM) are an ever-increasing challenge in oncology,...
Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.: Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.J Biol Chem. 2020 Sep 11;:Authors: Edwards MJ, Becker KA, Gripp B, Hoffmann M, Keitsch S, Wilker B, Soddemann M, Gulbins A, Carpinteiro E, Patel SH, Wilson GC, Pöhlmann S, Walter S, Fassbender K, Ahmad SA, Carpinteiro A, Gulbins EAbstract Sphingosine has been shown to prevent and eliminate bacterial infections of the respiratory tract,...
SARS-CoV-2 RNA contamination on surfaces of a COVID-19 ward in a hospital of Northern Italy: what risk of transmission?: OBJECTIVE: SARS-CoV-2 can reportedly exist on inanimate surfaces for a long duration, but there is limited data available from Italian COVID-19 hospital wards, especially for non-intensive care units hosting patients that do not require mechanical ventilation. Identification of the extent of environmental contamination can help in understanding possible virus transmission routes,...
A contemporary look at COVID-19 medications: available and potentially effective drugs: OBJECTIVE: There have been significant changes to the management of COVID-19 in recent months, including protocols and guidelines designed to prevent, diagnose, and treat the Novel Coronavirus (COVID-19). Several management options have been suggested and have since gained popularity, though we expect additional modifications to be made, as well as more new cases in the coming months, given a lack of definitive...
Nutraceuticals as immune-stimulating therapy to fight COVID-19. Combination of elements to improve the efficacy: COVID-19 pandemic has underlined that unknown viral infections, which jump from animals to humans, can be extremely dangerous. In case of new viruses as SARS-CoV2, available drugs can fail to contrast the virus aggressiveness leading patients to death. Long time is necessary to create a vaccine, but immediate solutions are necessary to stop the mortality COVID-19 related. We have learned...
An association between exposure to Middle East Respiratory Syndrome (MERS) and mortality rate of Coronavirus Disease 2019 (COVID-19): OBJECTIVE: Our objective was to find an association between exposure of a population to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and mortality rate due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) across different countries worldwide.MATERIALS AND METHODS: To find the relationship between exposure to MERS-CoV and mortality rate due...
SARS-CoV-2 infection: NLRP3 inflammasome as plausible target to prevent cardiopulmonary complications?: NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome has recently become an intriguing target of several chronic and viral diseases. Here, we argue that targeting NLRP3 inflammasome could be a strategy to prevent cardiovascular outcomes [fulminant myocarditis, heart failure, venous thromboembolism (VTE)] and acute respiratory distress syndrome (ARDS) in patients with SARS-CoV-2...
Imbalance between procoagulant factors and natural coagulation inhibitors contributes to hypercoagulability in the critically ill COVID-19 patient: clinical implications: OBJECTIVE: Coronavirus Disease-2019 (COVID-19) predisposes patients to thrombosis which underlying mechanisms are still incompletely understood. We sought to investigate the balance between procoagulant factors and natural coagulation inhibitors in the critically ill COVID-19 patient and to evaluate the usefulness of hemostasis...
Short report – Herpes simplex lesion in the lip semimucosa in a COVID-19 patient: OBJECTIVE: The present case report aims to make a discussion concerning oral manifestations in a patient with a confirmed diagnosis of COVID-19. Female patient, 20 years old, nursing technician, showed severe sore throat and headache without presence of fever. She tested positive for COVID-19 RT-PCR test in 2 episodes. She also showed lesions in the median lower lip semimucosa and severe pruritus, with a clinical course...
Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial.: Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial.Lancet Respir Med. 2020 Sep 09;:Authors: Lee LA, Bailes Z, Barnes N, Boulet LP, Edwards D, Fowler A, Hanania NA, Kerstjens...
A morphometric analysis of the immature human infraorbital canal.: A morphometric analysis of the immature human infraorbital canal.Surg Radiol Anat. 2020 Sep 12;:Authors: Smit S, Hutchinson EF, Kramer BAbstract PURPOSE: The importance of the infraorbital canal in the growth of the maxilla and associated mid-facial region has significance for innervation of this region as well as the associated dentition, yet little is known about the development of the canal. An analysis of its dimensions...
2-Oxothiazolidine-4-carboxylic acid inhibits vascular calcification via induction of glutathione synthesis.: 2-Oxothiazolidine-4-carboxylic acid inhibits vascular calcification via induction of glutathione synthesis.J Cell Physiol. 2020 Sep 12;:Authors: Patel JJ, Bourne LE, Thakur S, Farrington K, Gorog DA, Orriss IR, Baydoun ARAbstract Arterial medial calcification (AMC), the deposition of hydroxyapatite in the medial layer of the arteries, is a known risk factor for cardiovascular events....
The use of a second core needle biopsy to predict response to neoadjuvant chemotherapy in breast cancer patients, especially in the HER2-positive population.: The use of a second core needle biopsy to predict response to neoadjuvant chemotherapy in breast cancer patients, especially in the HER2-positive population.Surgery. 2020 Sep 08;:Authors: Zhang Y, Shen J, Wu S, Zhou Y, Shao Z, Liu GAbstract BACKGROUND: Early and accurate assessment of the response to neoadjuvant chemotherapy offers...
Trastuzumab Deruxtecan (DS-8201a): The Latest Research and Advances in Breast Cancer.: Trastuzumab Deruxtecan (DS-8201a): The Latest Research and Advances in Breast Cancer.Clin Breast Cancer. 2020 Aug 18;:Authors: Andrikopoulou A, Zografos E, Liontos M, Koutsoukos K, Dimopoulos MA, Zagouri FAbstract The development of antibody-drug conjugates composed of a cytotoxic agent and a monoclonal antibody carrier offers an important alternative to classic chemotherapy strategies. Trastuzumab deruxtecan...
Are Bethesda III Thyroid Nodules More Aggressive than Bethesda IV Thyroid Nodules When Found to Be Malignant?: Are Bethesda III Thyroid Nodules More Aggressive than Bethesda IV Thyroid Nodules When Found to Be Malignant?Cancers (Basel). 2020 Sep 09;12(9):Authors: Turkdogan S, Pusztaszeri M, Forest VI, Hier MP, Payne RJAbstract The Bethesda classification system for thyroid fine needle aspirate (FNA) is used to predict the risk of malignancy and to guide the management of thyroid nodules....
Targeted Therapies for Epstein-Barr Virus-Associated Lymphomas.: Targeted Therapies for Epstein-Barr Virus-Associated Lymphomas.Cancers (Basel). 2020 Sep 09;12(9):Authors: Pei Y, Wong JHY, Robertson ESAbstract The Epstein-Barr virus (EBV) is the first human tumor virus identified that can transform quiescent B lymphocytes into lymphoblastoid cell lines (LCLs) in vitro. EBV can establish asymptomatic life-long persistence and is associated with multiple human malignancies, including non-Hodgkin...
Deletion of p53 and Hyper-Activation of PIK3CA in Keratin-15+ Stem Cells Lead to the Development of Spontaneous Squamous Cell Carcinoma.: Deletion of p53 and Hyper-Activation of PIK3CA in Keratin-15+ Stem Cells Lead to the Development of Spontaneous Squamous Cell Carcinoma.Int J Mol Sci. 2020 Sep 09;21(18):Authors: Chen SMY, Li B, Nicklawsky AG, Krinsky AL, Brunetti T, Woolaver RA, Wang X, Chen Z, Young CD, Gao D, Wang XJ, Wang JHAbstract Squamous cell carcinoma (SCC) is the second commonest...
Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) in Oropharyngeal Cancer Associated with EBV and HPV Coinfection.: Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) in Oropharyngeal Cancer Associated with EBV and HPV Coinfection.Viruses. 2020 Sep 09;12(9):Authors: Strycharz-Dudziak M, Fołtyn S, Dworzański J, Kiełczykowska M, Malm M, Drop B, Polz-Dacewicz MAbstract Recent reports have pointed to the link between persistent inflammation, oxidative stress, and carcinogenesis;...
Factors for Predicting the Therapeutic Efficacy of Laryngeal Contact Granuloma.: Factors for Predicting the Therapeutic Efficacy of Laryngeal Contact Granuloma.J Voice. 2020 Sep 08;:Authors: Nie Q, Li J, Zou S, Zhang RAbstract OBJECTIVE: To explore the factors affecting the therapeutic efficacy of laryngeal contact granuloma. METHODS: The clinical data of 534 patients with laryngeal contact granuloma treated in our hospital from April 2014 to December 2019 were studied. The multivariable...
The impact of delayed diagnosis on the outcomes of oral cancer patients: a retrospective cohort study.: The impact of delayed diagnosis on the outcomes of oral cancer patients: a retrospective cohort study.Int J Oral Maxillofac Surg. 2020 Sep 08;:Authors: Thomas A, Manchella S, Koo K, Tiong A, Nastri A, Wiesenfeld DAbstract The contemporary literature is discordant regarding the role of delayed diagnosis in the prognosis of patients with oral cancer. This study examined data on a previously...
Effect of antibiotics on gut and vaginal microbiomes associated with cervical cancer development in mice.: Effect of antibiotics on gut and vaginal microbiomes associated with cervical cancer development in mice.Cancer Prev Res (Phila). 2020 Sep 11;:Authors: Karpinets TV, Solley TN, Mikkelson MD, Dorta-Estremera S, Nookala SS, Delgado Medrano AY, Petrosino JF, Mezzari MP, Zhang J, Futreal PA, Sastry KJ, Colbert LE, Klopp AAbstract Antibiotics affect microbial diversity in the gut, leading...
GFI1 functions to repress neuronal gene expression in the developing inner ear hair cells.: GFI1 functions to repress neuronal gene expression in the developing inner ear hair cells.Development. 2020 Sep 11;147(17):Authors: Matern MS, Milon B, Lipford EL, McMurray M, Ogawa Y, Tkaczuk A, Song Y, Elkon R, Hertzano RAbstract Despite the known importance of the transcription factors ATOH1, POU4F3 and GFI1 in hair cell development and regeneration, their downstream transcriptional cascades in...
Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma.: Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma.Cell Death Dis. 2020 Sep 11;11(9):743Authors: Dai W, Jin X, Han L, Huang H, Ji Z, Xu X, Tang M, Jiang B, Chen WAbstract...
Relevance of Intraparotid Metastases in Head and Neck Skin Squamous Cell Carcinoma.: Relevance of Intraparotid Metastases in Head and Neck Skin Squamous Cell Carcinoma.Laryngoscope. 2020 Sep 12;:Authors: Dür C, Salmina C, Borner U, Giger R, Nisa LNAbstract OBJECTIVES: Parotid lymph node metastases are common in head and neck cutaneous squamous cell carcinoma (cSCCHN). Here we evaluate the diagnostic, prognostic, and therapeutic implications of intraglandular lymph node (IGLN) metastases...
A phase 1, single centre, open label, escalating dose study to assess the safety, tolerability and immunogenicity of a therapeutic human papillomavirus (HPV) DNA vaccine (AMV002) for HPV-associated head and neck cancer (HNC).: A phase 1, single centre, open label, escalating dose study to assess the safety, tolerability and immunogenicity of a therapeutic human papillomavirus (HPV) DNA vaccine (AMV002) for HPV-associated head and neck cancer (HNC).Cancer Immunol Immunother. 2020 Sep 12;:Authors:...
Comparing Caliper versus Computed Tomography Measurements of Cranial Dimensions in Children.: Comparing Caliper versus Computed Tomography Measurements of Cranial Dimensions in Children.Laryngoscope. 2020 Sep 12;:Authors: Wu GT, Audlin JR, Grewal JS, Tatum SAAbstract OBJECTIVES/HYPOTHESIS: We have found no study assessing the accuracy of caliper cranium measurements compared to computed tomography (CT) measurements of the head. The objective of this study was to assess the reliability of...
Pediatric Tracheal Lobular Capillary Hemangioma: A Case Report and Review of the Literature.: Pediatric Tracheal Lobular Capillary Hemangioma: A Case Report and Review of the Literature.Laryngoscope. 2020 Sep 12;:Authors: Wang RY, Quintanilla NM, Chumpitazi BP, Gitomer S, Chiou EH, Ongkasuwan JAbstract Chronic cough is a common complaint in the pediatric population and can have many different etiologies. We present a rare case of a tracheal lobular capillary hemangioma (LCH), also known...
Polymorphisms in matricellular SPP1 and SPARC contribute to susceptibility to papillary thyroid cancer.: Polymorphisms in matricellular SPP1 and SPARC contribute to susceptibility to papillary thyroid cancer.Genomics. 2020 Sep 09;:Authors: Su X, Xu BH, Zhou DL, Ye ZL, He HC, Yang XH, Zhang X, Liu Q, Ma JJ, Shao Q, Yang AK, He CYAbstract There is a compelling need to identify novel genetic variants for papillary thyroid cancer (PTC) susceptibility. The Cancer Genome Atlas (TCGA) data showed...
Prognostic value of prognostic nutritional index in nasopharyngeal carcinoma: A meta-analysis containing 4511 patients.: Prognostic value of prognostic nutritional index in nasopharyngeal carcinoma: A meta-analysis containing 4511 patients.Oral Oncol. 2020 Sep 09;110:104991Authors: Tu X, Ren J, Zhao YAbstract OBJECTIVES: The prognostic nutritional index (PNI) is an index reflecting the nutritional and inflammatory status of patients and is explored for prognosis in nasopharyngeal carcinoma...
The prognostic value of TMB and the relationship between TMB and immune infiltration in head and neck squamous cell carcinoma: A gene expression-based study.: The prognostic value of TMB and the relationship between TMB and immune infiltration in head and neck squamous cell carcinoma: A gene expression-based study.Oral Oncol. 2020 Sep 09;110:104943Authors: Zhang L, Li B, Peng Y, Wu F, Li Q, Lin Z, Xie S, Xiao L, Lin X, Ou Z, Cai T, Rong H, Fan S, Li JAbstract OBJECTIVE: Whether tumor mutation...
Primary tumor resection of metastatic gastric cancer in a multimodal era: Two case reports.: Primary tumor resection of metastatic gastric cancer in a multimodal era: Two case reports.Int J Surg Case Rep. 2020 Aug 29;75:42-45Authors: Takeda FR, Garcia RN, Ueda SKN, Peixoto RD, Sallum RAA, Cecconello IAbstract INTRODUCTION: Although no consensus has been reached on the role of surgical treatment for metastatic gastric cancer, some reports suggest promising results on patients with a small...
An uncommon form of localized colonic eosinophilic vasculitis with extensive thrombosis of the spleen and liver: A case report and literature review.: An uncommon form of localized colonic eosinophilic vasculitis with extensive thrombosis of the spleen and liver: A case report and literature review.Int J Surg Case Rep. 2020 Sep 06;75:50-52Authors: Huang SH, Wu RC, Liao CKAbstract INTRODUCTION: Localized vasculitis of the gastrointestinal tract is an uncommon disease that mainly presents...
An atypical presentation of gigantiform torus palatinus: A case report: Atypical tori palatine and surgical management.: An atypical presentation of gigantiform torus palatinus: A case report: Atypical tori palatine and surgical management.Int J Surg Case Rep. 2020 Sep 04;75:66-70Authors: Bernaola-Paredes WE, Pereira AM, Albuquerque Luiz TA, Martins IS, Lima FF, Vallejo-Rosero KAAbstract INTRODUCTION: Torus palatinus (TP) is a slow growing maxillary exostosis, commonly found in the in the...
Approaching 10 years disease-free survival after isolated thoracic perfusion for advanced stage IV tonsil carcinoma: A case report.: Approaching 10 years disease-free survival after isolated thoracic perfusion for advanced stage IV tonsil carcinoma: A case report.Int J Surg Case Rep. 2020 Sep 03;75:71-74Authors: Aigner KR, Selak E, Aigner KAbstract INTRODUCTION: This is a report about the first case of an advanced stage IV tonsil carcinoma treated with isolated thoracic perfusion and chemofiltration....
Case report demonstrating abdominal tuberculosis presenting as an irreducible para-umbilical hernia.: Case report demonstrating abdominal tuberculosis presenting as an irreducible para-umbilical hernia.Int J Surg Case Rep. 2020 Sep 06;75:75-77Authors: Wellmann MH, Tariq HA, De Jager-Wood CAbstract INTRODUCTION: Abdominal tuberculosis is a common form of extrapulmonary tuberculosis. Clinical manifestations and presentations are diverse depending on the organ involved within the abdominal...
Extra digital glomus tumor: A very rare cause of chronic abdominal wall pain.: Extra digital glomus tumor: A very rare cause of chronic abdominal wall pain.Int J Surg Case Rep. 2020 Sep 06;75:78-80Authors: Dar PMUD, Wani AA, Malik LA, Mushtaq SAbstract INTRODUCTION: Glomus tumors are very rare benign vascular tumors, constituting less than 2% of soft tissue tumors. These tumors originate from the glomus body. 75% of these tumors occur in hand however rarely can be found in any body part....
Gallbladder volvulus, a rare cause of acute abdomen, a case report.: Gallbladder volvulus, a rare cause of acute abdomen, a case report.Int J Surg Case Rep. 2020 Sep 06;75:81-84Authors: Bouzas Cardaci M, Bivoleanu CVAbstract INTRODUCTION: The gallbladder volvulus is a rare surgical emergency and its defined as the rotation of the gallbladder on its mesentery along the axis of the cystic duct and cystic artery. Definitive diagnosis is usually made during surgery and a delay in treatment may...
Extensive parapharyngeal lymphangioma in a adult-Case report and review of literature.: Extensive parapharyngeal lymphangioma in a adult-Case report and review of literature.Int J Surg Case Rep. 2020 Aug 29;75:85-88Authors: Balineni P, C H VPK, Reddy E D, Reddy JSAbstract INTRODUCTION: Lymphangiomas are benign swellings most commonly seen in paediatric population. Head and neck are the common sites of presentation rarely can also been seen other sites as axilla, chest, abdomen, liver, spleen....
Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma.: Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma.Taiwan J Obstet Gynecol. 2020 Sep;59(5):698-705Authors: Wang CC, Chen BK, Chen PH, Chen LCAbstract OBJECTIVE: The aim of this study was to examine the antitumor activity of hinokitiol for its clinical...
Primary malignant peripheral nerve sheath tumour of the trachea: a case report and literature review.: Primary malignant peripheral nerve sheath tumour of the trachea: a case report and literature review.J Cardiothorac Surg. 2020 Sep 11;15(1):247Authors: Hu Y, Ren S, Han W, Zhang B, Shu L, Sun Y, Yu F, Liu WAbstract BACKGROUND: Malignant peripheral nerve sheath tumours (MPNSTs) of the trachea are extremely uncommon neoplasms with unknown genetic and clinical profiles. Only individual cases...
Clinical characteristics of KCNQ2 encephalopathy.: Clinical characteristics of KCNQ2 encephalopathy.Brain Dev. 2020 Sep 08;:Authors: Kim HJ, Yang D, Kim SH, Won D, Kim HD, Lee JS, Choi JR, Lee ST, Kang HCAbstract PURPOSE: KCNQ2 mutations are associated with benign familial neonatal epilepsy (BFNE) or developmental and epileptic encephalopathy (DEE). In this study, we aimed to delineate the phenotype of KCNQ2 encephalopathy and evaluate the treatment response. METHODS: Thirteen patients...
Brain-responsive corticothalamic stimulation in the centromedian nucleus for the treatment of regional neocortical epilepsy.: Brain-responsive corticothalamic stimulation in the centromedian nucleus for the treatment of regional neocortical epilepsy.Epilepsy Behav. 2020 Sep 09;112:107354Authors: Burdette DE, Haykal MA, Jarosiewicz B, Fabris RR, Heredia G, Elisevich K, Patra SEAbstract OBJECTIVE: The aim of the study was to determine if corticothalamic responsive stimulation targeting the...
Clinical characteristics and outcomes in pregnant women with epilepsy.: Clinical characteristics and outcomes in pregnant women with epilepsy.Epilepsy Behav. 2020 Sep 09;112:107433Authors: Huang CY, Dai YM, Feng LM, Gao WLAbstract BACKGROUND: Epilepsy in pregnancy can lead to substantial maternal and neonatal morbidity and mortality. Early intervention in pregnant women with epilepsy (WWE), accurate assessment of the severity of their condition, and effective treatment are required to improve...
Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches.: Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches.Medicina (Kaunas). 2020 Sep 09;56(9):Authors: Filip L, Duică F, Prădatu A, Crețoiu D, Suciu N, Crețoiu SM, Predescu DV, Varlas VN, Voinea SCAbstract Endometriosis represents a frequently diagnosed gynecological affliction in the reproductive timespan of women,...
Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing.: Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing.Int J Environ Res Public Health. 2020 Sep 09;17(18):Authors: Adam-Bonci TI, Cherecheș-Panța P, Bonci EA, Man SC, Cutaș-Benedec A, Drugan...
PSMA-PET identifies PCWG3 target populations with superior accuracy and reproducibility when compared to conventional imaging: a multicenter retrospective study.: PSMA-PET identifies PCWG3 target populations with superior accuracy and reproducibility when compared to conventional imaging: a multicenter retrospective study.J Nucl Med. 2020 Sep 11;:Authors: Farolfi A, Hirmas N, Gafita A, Weber M, Barbato F, Wetter A, Mei R, Pianori D, Hadaschik B, Herrmann K, Castellucci P, Fanti S, Eiber M, Fendler...
Vitamin D Receptor Polymorphisms and Cancer.: Vitamin D Receptor Polymorphisms and Cancer.Adv Exp Med Biol. 2020;1268:53-114Authors: Gnagnarella P, Raimondi S, Aristarco V, Johansson HA, Bellerba F, Corso F, Gandini SAbstract Increasing scientific evidence supports the link between vitamin D and cancer risk. The active metabolite 1,25(OH)2D exerts its activity by binding to the vitamin D receptor (VDR), an intracellular receptor that mediates transcriptional activation and repression of...
Analysis of cardiac motion without respiratory motion for cardiac stereotactic body radiation therapy.: Analysis of cardiac motion without respiratory motion for cardiac stereotactic body radiation therapy.J Appl Clin Med Phys. 2020 Sep 12;:Authors: Ouyang Z, Schoenhagen P, Wazni O, Tchou P, Saliba WI, Suh JH, Xia PAbstract PURPOSE/OBJECTIVE(S): To study the heart motion using cardiac gated computed tomographies (CGCT) to provide guidance on treatment planning margins during cardiac stereotactic...
Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior: AbstractRationaleCurrently available PDE2 inhibitors have poor brain penetration that limits their therapeutic utility in the treatment of depression. Hcyb1 is a novel selective PDE2 inhibitor that was introduced more lipophilic groups with polar functionality to the scaffold pyrazolopyrimidinone to improve the blood-brain barrier (BBB) penetration. Our previous study suggested that Hcyb1...
Co-delivery of Paclitaxel and Curcumin by Biodegradable Polymeric Nanoparticles for Breast Cancer Chemotherapy.: Co-delivery of Paclitaxel and Curcumin by Biodegradable Polymeric Nanoparticles for Breast Cancer Chemotherapy.Int J Pharm. 2020 Sep 09;:119875Authors: Xiong Writing-Original Draft K, Zhang Y, Wen Q, Luo J, Lu Y, Wu Z, Wang B, Chen Y, Zhao L, Fu SAbstract Multi-drug chemotherapy has been one of the most popular strategies for the treatment of malignant tumors, and has achieved...
Solarium Use and Risk for Malignant Melanoma: Many Open Questions, Not the Time to Close the Debate.: Solarium Use and Risk for Malignant Melanoma: Many Open Questions, Not the Time to Close the Debate.Adv Exp Med Biol. 2020;1268:155-170Authors: Burgard B, Reichrath JAbstract To shed further light on the ongoing debate whether sunbed use may increase melanoma risk, we have critically assessed the scientific literature that is at present available, focussing on a meta-analysis that we published...
Lactobacillus fermentum promotes adipose tissue oxidative phosphorylation to protect against diet-induced obesity.: Lactobacillus fermentum promotes adipose tissue oxidative phosphorylation to protect against diet-induced obesity.Exp Mol Med. 2020 Sep 11;:Authors: Yoon Y, Kim G, Noh MG, Park JH, Jang M, Fang S, Park HAbstract The gut microbiota has pivotal roles in metabolic homeostasis and modulation of the intestinal environment. Notably, the administration of Lactobacillus spp. ameliorates...
Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases.: Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases.Exp Mol Med. 2020 Sep 11;:Authors: Jo DS, Park NY, Cho DHAbstract In recent decades, the role of the peroxisome in physiology and disease conditions has become increasingly important. Together with the mitochondria and other cellular organelles, peroxisomes support key metabolic platforms for the oxidation...
Human kidney organoids produce functional renin.: Human kidney organoids produce functional renin.Kidney Int. 2020 Sep 09;:Authors: Shankar AS, Du Z, Mora HT, van den Bosch TPP, Korevaar SS, Van den Berg-Garrelds IM, Bindels E, Lopez-Iglesias C, Groningen MC, Gribnau J, Baan CC, Danser AHJ, Hoorn EJ, Hoogduijn MJAbstract Renin production by the kidney is of vital importance for salt, volume, and blood pressure homeostasis. The lack of human models hampers investigation into the regulation...
Connexin 32 induces pro-tumorigenic features in MCF10A normal breast cells and MDA-MB-231 metastatic breast cancer cells.: Connexin 32 induces pro-tumorigenic features in MCF10A normal breast cells and MDA-MB-231 metastatic breast cancer cells.Biochim Biophys Acta Mol Cell Res. 2020 Sep 09;:118851Authors: Adak A, Unal YC, Yucel S, Vural Z, Turan FB, Yalcin-Ozuysal O, Ozcivici E, Mese GAbstract Connexins (Cx), the basic subunit of gap junctions, play important roles in cell homeostasis, and...
Expression of Concern: MiR-210 suppresses neuronal apoptosis in rats with cerebral infarction through regulating VEGF-notch signaling pathway: The Editorial Board of European Review for Medical and Pharmacological Sciences would like to issue an Expression of Concern for "MiR-210 suppresses neuronal apoptosis in rats with cerebral infarction through regulating VEGF-notch signaling pathway", by Y.-L. Jiang, W.-W. Liu, Y. Wang, W.-Y. Yang, published in Eur Rev Med Pharmacol Sci 2020; 24 (9): 4971-4978–DOI:...
Associations of BMI and Serum Urate with Developing Dementia: A Prospective Cohort Study.: Associations of BMI and Serum Urate with Developing Dementia: A Prospective Cohort Study.J Clin Endocrinol Metab. 2020 Sep 12;:Authors: Cao Z, Xu C, Yang H, Li S, Xu F, Zhang Y, Wang YAbstract CONTEXT: Recent studies suggested that higher BMI and serum urate levels were associated with lower risk of developing dementia. However, these reverse relationships remain controversial, and whether serum urate...
Ultrasonography for the Prediction of High-Volume Lymph Node Metastases in Papillary Thyroid Carcinoma: Should Surgeons Believe Ultrasound Results?: Ultrasonography for the Prediction of High-Volume Lymph Node Metastases in Papillary Thyroid Carcinoma: Should Surgeons Believe Ultrasound Results?World J Surg. 2020 Sep 11;:Authors: Liu C, Zhang L, Liu Y, Xia Y, Cao Y, Liu Z, Chen G, Liu N, Shang Z, Yang J, Sun Q, Li XAbstract BACKGROUND: Lymph node metastasis (LNM) often occurs in papillary...
A nucleus-directed bombesin derivative for targeted delivery of metallodrugs to cancer cells.: A nucleus-directed bombesin derivative for targeted delivery of metallodrugs to cancer cells.J Inorg Biochem. 2020 Aug 10;212:111214Authors: Barrabés S, Ng-Choi I, Martínez MÁ, Manzano BR, Jalón FA, Espino G, Feliu L, Planas M, de Llorens R, Massaguer AAbstract We have synthesized a set of bombesin derivatives with the aim of exploring their tumor targeting properties to deliver metal-based chemotherapeutics...
Exploring anticancer efficiency of mitochondria-targeted cyclometalated iridium(III) complexes.: Exploring anticancer efficiency of mitochondria-targeted cyclometalated iridium(III) complexes.J Inorg Biochem. 2020 Aug 08;212:111215Authors: Gu Y, Wen H, Bai L, Zhou Y, Zhang H, Tian L, Zhang Y, Hao J, Liu YAbstract We prepared and characterized new iridium(III) complexes: [Ir(NC)2(MPPIP)](PF6) (N-C = 2-phenylpyridine 1; benzo[h]quinolone 2; 1-phenylisoquinolone, 3, MPPIP = 2-(4-(4'-methylpiperazin-yl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline)....
Using 3D-reconstruction to analyse typical growth trends of the maxillary sinus in children.: Using 3D-reconstruction to analyse typical growth trends of the maxillary sinus in children.Int J Pediatr Otorhinolaryngol. 2020 Aug 29;138:110334Authors: Lee S, Fernandez JW, Mahadevan M, Tarr G, Mirjalili AAbstract OBJECTIVES: There remains a lack of consistent evidence surrounding the developmental anatomy of the maxillary sinus (MS), despite its clinical significance in radiological interpretation...
The Oxford Fingernail Appearance Score - a new scoring system for fingernail deformity following paediatric finger tip trauma.: The Oxford Fingernail Appearance Score - a new scoring system for fingernail deformity following paediatric finger tip trauma.J Plast Reconstr Aesthet Surg. 2020 Aug 05;:Authors: Jain A, Stokes J, Gardiner MD, Cook JA, Jones A, Cooper C, Shirkey B, Sierakowski A, Beard D, Greig AVH, Dupré S, Adami RZ, Baker B, Fleet M, Miles D, Nicholas R, Nicola A, Plonczak A, Sleiwah...
Trapezoidal fractures: Overview and introduction of a novel diagnostic classification system.: Trapezoidal fractures: Overview and introduction of a novel diagnostic classification system.J Plast Reconstr Aesthet Surg. 2020 Aug 25;:Authors: Safran T, Hazan J, Viezel-Mathieu A, Joe Azzi A, Boily M, Thibaudeau SAbstract INTRODUCTION: Trapezoidal fractures account for only 0.4% of all carpal bone fractures. Owing to their rarity, there is paucity in the literature regarding the clinical findings...
Outcomes of free vascularized fibular flaps for the treatment of radiation-associated femoral nonunions.: Outcomes of free vascularized fibular flaps for the treatment of radiation-associated femoral nonunions.J Plast Reconstr Aesthet Surg. 2020 Sep 04;:Authors: Tibbo ME, Houdek MT, Bakri K, Rose PS, Sems SA, Moran SLAbstract INTRODUCTION: Nonunion is a known complication following fracture in the setting of radiotherapy. Free vascularized fibular (FVF) flaps have been used successfully...
Autologous fat grafting seems to alleviate postherpetic neuralgia - a feasibility study investigating patient-reported levels of pain.: Autologous fat grafting seems to alleviate postherpetic neuralgia - a feasibility study investigating patient-reported levels of pain.J Plast Reconstr Aesthet Surg. 2020 Aug 21;:Authors: Sollie M, Thomsen JB, Sørensen JAAbstract BACKGROUND: Postherpetic neuralgia (PHN) is a relatively common side effect after an outbreak of herpes zoster (HZ), characterized...
Histopathological Definitions of Extranodal Extension: A Systematic Review.: Histopathological Definitions of Extranodal Extension: A Systematic Review.Head Neck Pathol. 2020 Sep 12;:Authors: Abdel-Halim CN, Rosenberg T, Larsen SR, Høilund-Carlsen PF, Sørensen JA, Rohde M, Godballe CAbstract Extranodal extension (ENE) is a very strong prognostic factor in head and neck squamous cell carcinoma. However, significant variance in reported incidence of ENE suggests discordance in perception of...
Histopathological Definitions of Extranodal Extension: A Systematic Review.: Histopathological Definitions of Extranodal Extension: A Systematic Review.Head Neck Pathol. 2020 Sep 12;:Authors: Abdel-Halim CN, Rosenberg T, Larsen SR, Høilund-Carlsen PF, Sørensen JA, Rohde M, Godballe CAbstract Extranodal extension (ENE) is a very strong prognostic factor in head and neck squamous cell carcinoma. However, significant variance in reported incidence of ENE suggests discordance in perception of...
Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood.: Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood.Proc Natl Acad Sci U S A. 2020 Sep 11;:Authors: Mackey E, Thelen KM, Bali V, Fardisi M, Trowbridge M, Jordan CL, Moeser AJAbstract Mast cell (MC)-associated diseases, including allergy/anaphylaxis and neuroinflammatory pain disorders, exhibit a sex bias, with females at increase...
The sellar barrier on preoperative imaging predicts intraoperative cerebrospinal fluid leak: a prospective multicenter cohort study.: The sellar barrier on preoperative imaging predicts intraoperative cerebrospinal fluid leak: a prospective multicenter cohort study.Pituitary. 2020 Sep 12;:Authors: Villalonga JF, Solari D, Cavallo LM, Cappabianca P, Prevedello DM, Carrau R, Martinez-Perez R, Hardesty D, Fuchssteiner C, Saenz A, Abbritti RV, Valencia-Ramos C, Kaen A, Bernat AL, Cardenas E, Hirtler...
Poorly differentiated chordoma with whole‐genome doubling evolving from a SMARCB1‐deficient conventional chordoma: a case report: AbstractEvolution of poorly differentiated chordoma from conventional chordoma has not been previously reported. We encountered a case of a poorly differentiated chordoma with evidence of whole‐genome doubling arising from a SMARCB1‐deficient conventional chordoma. The tumor presented as a destructive sacral mass in a 43‐year‐old man and was comprised of a highly cellular...
The effects of microglia‐ and astrocyte‐derived factors on neurogenesis in health and disease: AbstractHippocampal neurogenesis continues throughout life and has been suggested to play an essential role in maintaining spatial cognitive function under physiological conditions. An increasing amount of evidence has indicated that adult neurogenesis is tightly controlled by environmental conditions in the neurogenic niche, which consists of multiple types of cells including microglia and astrocytes....
Anatomical Study of the Descending Genicular Artery and Implications for Image‐Guided Interventions for Knee Pain: AbstractIntroductionThe descending genicular artery (DGA) has recently been mentioned as accompanying some nerves in the medial aspect of the knee joint. This could be clinically relevant as the arteries could serve as landmarks for accurate nerve capture during ultrasound‐guided nerve blockade or ablation. The aim of this cadaveric study was to investigate the anatomical distribution...
Protective role of histone deacetylase 4 from ultraviolet radiation‐induced DNA lesions: AbstractUltraviolet B (UVB) exposure is a core factor that leads to skin disease or carcinogenesis through the insufficient repair of DNA lesions. UVB‐induced DNA lesions are mainly removed by the nucleotide excision repair (NER) mechanism. The expression of histone deacetylase 4 (HDAC4) is altered in the skin upon UVB exposure, indicating its possible implication in UVB‐induced DNA lesions repair. Here, we investigated...
Tooth extraction without discontinuation of oral antithrombotic treatment: a prospective study.: AbstractObjectiveTo identify which variable, among those related to surgeries, to patients or to antithrombotic treatments, could be considered as a bleeding indicator, and to analyze effectiveness of the local hemostatic protocols used, incidence of bleeding and healing index, depending on the number of extracted teeth and patient antithrombotic treatment.MethodsPatients who underwent tooth extractions...
Functional tongue and floor of mouth reconstruction with a chimeric flap after total glossectomy: AbstractPurposePresently, the functional reconstruction of the tongue in patients after subtotal or total glossectomy with the removal of the oral floor muscles and spearing of the larynx remains a complicated and unsolved issue. The aim of this case is to describe a method reconstruction of the tongue in patients after total glossectomy with the removal of the oral floor muscles using the chimeric latissimus...
Efficacy of argon‐helium cryoablation andits effects on immune function of patients with neck malignant tumors: AbstractObjectivesOur study aimedto investigate the clinical efficacy of argon‐helium cryoablation and its effects on the immune function of patients with neck malignant tumors.DesignRetrospective study.SettingSingle‐institution academic tertiary care center.MethodsTotally 180 patients harboring head and neck malignant tumors were divided intothe the argon‐helium cryoablation group(n=150)...
Reliability assessment on intravascular photoacoustic imaging of lipid: Ex vivo animal and human sample validation: ABSTACTAlthough the lipid‐detecting IVPA imaging system has been developed in resolution, speed and catheter size, there is no parameterization study of the reliability on the IVPA imaging for lipid diagnosis. Here, the sensitivity, specificity and accuracy were calculated to assess the reliability of the IVPA imaging of lipid. Abdominal aortas from 6 rabbits with atherosclerosis, were...
Exposure-response assessment of cancer mortality in styrene-exposed boatbuilders: Objectives To improve exposure estimates and reexamine exposure–response relationships between cumulative styrene exposure and cancer mortality in a previously studied cohort of US boatbuilders exposed between 1959 and 1978 and followed through 2016.Methods Cumulative styrene exposure was estimated from work assignments and air-sampling data. Exposure–response relationships between styrene and select cancers were...
Maternal preconception and first trimester exposure to PM10 and the risk of oral clefts in offspring: a population-based, case-control study: Background Current literature describes limited and controversial evidence on the associations between maternal preconception and first trimester exposure to particulate matter with a diameter ≤10 µm (PM10) and the risk of oral cleft (OC).Methods We conducted a case–control study involving 3086 OC cases and 7950 controls, registered in the Maternal and Child...
Occupational exposure to whole-body vibrations and pregnancy complications: a nationwide cohort study in Sweden: Objectives Pregnancy complications are common contributors to perinatal mortality and morbidity. Still, the cause(s) of gestational hypertensive disorders and diabetes are largely unknown. Some occupational exposures have been inconsistently associated with pregnancy complications, but exposure to whole-body vibrations (WBV) has been largely overlooked even though it has been associated...
Maternal occupational exposure to solvents and gastroschisis in offspring: are gene-environment interactions playing a role?: In a recent issue of Occupational and Environmental Medicine, a study by Spinder et al1 reported the results of the association between maternal occupational exposure to solvents and gastroschisis in offspring. Spinder et al found that among 879 cases and 7817 controls, the overall prevalence of periconceptional solvent exposure was 7.3% and 7.4%, respectively, and exposure...
Cynical hostility relates to a lack of habituation of the cardiovascular response to repeated acute stress: AbstractHostility is associated with increased risk for cardiovascular disease. Heightened cardiovascular reactivity to psychological stress has been proposed as a potential mechanism. Recent work has emphasized a need to measure cardiovascular reactivity across multiple stress exposures to assess potential habituation over time. The aims of the current study were (a) to examine the relationship...
Frontal alpha asymmetry and emotional processing in youth with psychopathic traits: AbstractEmotional processing deficits are often considered central to psychopathy. There is evidence that those high in psychopathy pay less attention to emotional stimuli, and it is possible that these individuals experience diminished withdrawal motivation or heightened approach motivation in response to emotional stimuli. Studying emotional processing abnormalities, especially among youth, may be essential for...
A prediction modeling based on SNOT-22 score for endoscopic nasal septoplasty: a retrospective study: Background To create a nomogram prediction model for the efficacy of endoscopic nasal septoplasty, and the likelihood of patient benefiting from the operation. Methods A retrospective analysis of 155 patients with nasal septum deviation (NSD) was performed to develop a predictive model for the efficacy of endoscopic nasal...
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