1affa2-ehtfy.htmlNeurological Sciences, Vol. 41, Issue 2 - New Issue Alert.eml 2ay2mh-61xzs.htmlEuropean Journal of Nuclear Medicine and Molecular Imaging, Vol. 47, Issue 3 - New Issue Alert.eml 3anttp-3iw9k.htmlBehavior Research Methods, Vol. 52, Issue 1 - New Issue Alert.eml 4amvnh-cowp1.htmlBiomechanics and Modeling in Mechanobiology, Vol. 19, Issue 1 - New Issue Alert.eml 5a4vkl-pjcf3.htmlAnnals of Operations Research, Vol. 286, Issue 1 - New Issue Alert.eml 6amlra-qrdvt.htmlJournal of Earth...
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International Journal of Molecular SciencesIJMS, Vol. 21, Pages 1172: Transposon Insertion Mutagenesis in Mice for Modeling Human Cancers: Critical Insights Gained and New OpportunitiesIJMS, Vol. 21, Pages 1172: Transposon Insertion Mutagenesis in Mice for Modeling Human Cancers: Critical Insights Gained and New Opportunities International Journal of Molecular Sciences doi: 10.3390/ijms21031172 Authors: Beckmann Largaespada Transposon mutagenesis has been used to model many types of human cancer...
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AntibioticsAntibiotics, Vol. 9, Pages 73: Molecular Characterization Of Pathogenic Salmonella Spp From Raw Beef In Karachi, PakistanAntibiotics, Vol. 9, Pages 73: Molecular Characterization Of Pathogenic Salmonella Spp From Raw Beef In Karachi, Pakistan Antibiotics doi: 10.3390/antibiotics9020073 Authors: Altaf Hussain Wang Sun Gu Liu Yu Ahmad Jiang Hou The aim of the present study was to estimate the prevalence of Salmonella and investigate the dominant serovars distribution in raw beef and to...
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Risk factors and associated complications with unplanned intubation in patients with craniotomy for brain tumor.: Related ArticlesRisk factors and associated complications with unplanned intubation in patients with craniotomy for brain tumor.J Clin Neurosci. 2020 Feb 05;:Authors: Li YI, Ventura N, Towner JE, Li K, Roberts DE, Li YMAbstract Patients undergoing surgical resection of a brain tumor have the potential risk for beingintubated post-operatively, which may be associated with significant...
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The clinical characters and gene detection in a familial temporal lobe epilepsy with auditory aura.: Related ArticlesThe clinical characters and gene detection in a familial temporal lobe epilepsy with auditory aura.J Clin Neurosci. 2020 Feb 05;:Authors: Zhang L, Jia Y, Wang YAbstract Auditory aura was the very important clinical character in familial temporal Lobe epilepsy. LGI1 was the main pathogenic gene. The inheritance mode of this disease was autosomal dominant. We describes the clinical...
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Absolute Lymphocyte Count Predicts Abscopal Responses and Outcomes in Patients Receiving Combined Immunotherapy and Radiotherapy: A prospective-retrospective analysis of 3 phase I/II Trials.: Related ArticlesAbsolute Lymphocyte Count Predicts Abscopal Responses and Outcomes in Patients Receiving Combined Immunotherapy and Radiotherapy: A prospective-retrospective analysis of 3 phase I/II Trials.Int J Radiat Oncol Biol Phys. 2020 Feb 06;:Authors: Chen D, Verma V, Patel RR, Barsoumian HB, Cortez MA,...
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Protons show greater relative biological effectiveness for mammary tumorigenesis with higher ERα and HER2 positive tumors relative to γ-rays in APCMin/+ mice.: Related ArticlesProtons show greater relative biological effectiveness for mammary tumorigenesis with higher ERα and HER2 positive tumors relative to γ-rays in APCMin/+ mice.Int J Radiat Oncol Biol Phys. 2020 Feb 06;:Authors: Suman S, Shuryak I, Kallakury B, Brenner DJ, Fornace AJ, Johnson MD, Datta KAbstract PURPOSE: Exposure to ionizing...
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CYFRA 21-1 and MMP-9 as salivary biomarkers for the detection of oral squamous cell carcinoma: a systematic review of diagnostic test accuracy.: Related ArticlesCYFRA 21-1 and MMP-9 as salivary biomarkers for the detection of oral squamous cell carcinoma: a systematic review of diagnostic test accuracy.Int J Oral Maxillofac Surg. 2020 Feb 05;:Authors: AlAli AM, Walsh T, Maranzano MAbstract Tissue biopsy with histopathological examination is still considered the gold standard to diagnose oral...
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Co-Expression of Membrane-Bound Tumor Necrosis Factor-Alpha Receptor Types 1 and 2 by Tumor Cell Lines.: Related ArticlesCo-Expression of Membrane-Bound Tumor Necrosis Factor-Alpha Receptor Types 1 and 2 by Tumor Cell Lines.Int Arch Allergy Immunol. 2020 Feb 07;:1-8Authors: Alshevskaya AA, Belomestnova I, Lopatnikova JA, Zhukova J, Evsegneeva I, Koneva O, Karaulov AV, Sennikov SVAbstract INTRODUCTION: Density and co-expression of tumor necrosis factor (TNF) receptors may vary among cell populations....
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Pathologic Grading of Mucoepidermoid Carcinomas of the Salivary Gland and its Effect on Clinicopathologic Follow-up: An Institutional Experience.: Related ArticlesPathologic Grading of Mucoepidermoid Carcinomas of the Salivary Gland and its Effect on Clinicopathologic Follow-up: An Institutional Experience.Hum Pathol. 2020 Feb 06;:Authors: Shafique K, Zhang PJ, Montone KT, Song S, Livolsi VA, Baloch ZAbstract BACKGROUND: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary...
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European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Vascular Graft and Stent Graft Infections With the Endorsement of the European Association of Nuclear Medicine (EANM).: Related ArticlesEuropean Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Vascular Graft and Stent Graft Infections With the Endorsement of the European Association of Nuclear Medicine (EANM).Eur J Vasc Endovasc Surg. 2020 Jan 30;:Authors:...
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Polarity- and Intensity-Independent Modulation of Timing During Delay Eyeblink Conditioning Using Cerebellar Transcranial Direct Current Stimulation.: Related ArticlesPolarity- and Intensity-Independent Modulation of Timing During Delay Eyeblink Conditioning Using Cerebellar Transcranial Direct Current Stimulation.Cerebellum. 2020 Feb 08;:Authors: Mitroi J, Burroughs LP, Moussa-Tooks AB, Bolbecker AR, Lundin NB, O'Donnell BF, Hetrick WPAbstract Delay eyeblink conditioning (dEBC) is widely...
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Evaluation of the bioequivalence and food effect on the bioavailability of CC-486 (oral azacitidine) tablets in adult patients with cancer.: Related ArticlesEvaluation of the bioequivalence and food effect on the bioavailability of CC-486 (oral azacitidine) tablets in adult patients with cancer.Cancer Chemother Pharmacol. 2020 Feb 08;:Authors: Babiker HM, Milhem M, Aisner J, Edenfield W, Shepard D, Savona M, Iyer S, Abdelrahim M, Beach CL, Skikne B, Laille E, Tsai KT, Ho TAbstract PURPOSE:...
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[CAR-T cells in acute lymphoblastic leukemias: What's new?]: Related Articles[CAR-T cells in acute lymphoblastic leukemias: What's new?]Bull Cancer. 2020 Feb 05;:Authors: Grain A, Dourthe ME, Baruchel AAbstract The approval of tisagenlecleucel in B-lineage acute lymphoblastic leukemias in 2017 in the USA and in 2018 in Europe not only opened new hopes but forced to rethink the hospital organizations around this innovation. Indeed, if these treatments are very effective in the short term,...
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Preventative and management strategies of hypocalcemia after thyroidectomy among surgeons: An international survey study.: Related ArticlesPreventative and management strategies of hypocalcemia after thyroidectomy among surgeons: An international survey study.Am J Otolaryngol. 2020 Jan 25;:102394Authors: Sulibhavi A, Rubin SJ, Park J, Hashemi S, DePietro JD, Noordzij JPAbstract OBJECTIVE: To determine international surgeon practice patterns for transient postoperative hypocalcemia in patients...
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Aspergillus flavus malignant external otitis in a diabetic patient: case report and literature review.: Related ArticlesAspergillus flavus malignant external otitis in a diabetic patient: case report and literature review.Infection. 2020 Feb 08;:Authors: Pichon M, Joly V, Argy N, Houze S, Bretagne S, Alanio A, Wassef M, Verillaud B, Yazdanpanah YAbstract PURPOSE: Malignant external otitis is an aggressive and potentially life-threatening infection. This rare disorder is typically caused by...
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Limitations and drawbacks of the hospital-based universal neonatal hearing screening program: First report from the Arabian Peninsula and insights.: Related ArticlesLimitations and drawbacks of the hospital-based universal neonatal hearing screening program: First report from the Arabian Peninsula and insights.Int J Pediatr Otorhinolaryngol. 2020 Feb 03;132:109926Authors: Kolethekkat AA, Al Abri R, Hlaiwah O, Al Harasi Z, Al Omrani A, Sulaiman AA, Al Bahlani H, Al Jaradi M, Mathew JAbstract ...
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Evaluating the Psychometric Properties of the Kannada Version of EAT 10.: Related ArticlesEvaluating the Psychometric Properties of the Kannada Version of EAT 10.Dysphagia. 2020 Feb 08;:Authors: Krishnamurthy R, Balasubramanium RK, Hegde PSAbstract BACKGROUND: Eating Assessment Tool 10 is a symptom survey and has several advantages over other existing questionnaires. The instrument has also proven to be useful in establishing initial dysphagia symptom severity and to aid in measuring treatment...
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Challenging tracheal resection anastomosis: Case series.: Related ArticlesChallenging tracheal resection anastomosis: Case series.Auris Nasus Larynx. 2020 Feb 05;:Authors: Ebada HA, Abd El-Fattah AM, Salem EH, Elkotb MY, Kamal E, Tawfik AAbstract OBJECTIVES: This study was conducted to review our experience in Otorhinolaryngology Department, Mansoura University Hospitals, Egypt, in the last 2 years in the management of high-risk patients who underwent cricotracheal resection due to different...
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Cancer Rehabilitation:: Acute and Chronic Issues, Nerve Injury, Radiation Sequelae, Surgical and Chemo-Related, Part 2.: Related ArticlesCancer Rehabilitation:: Acute and Chronic Issues, Nerve Injury, Radiation Sequelae, Surgical and Chemo-Related, Part 2.Med Clin North Am. 2020 Mar;104(2):251-262Authors: Nori P, Kline-Quiroz C, Stubblefield MDAbstract Cancer affects millions of individuals, and approximately half will develop functional impairments. Cancers that commonly, either from direct...
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Risk factors for posttreatment recurrence in patients with intermediate-risk papillary thyroid carcinoma.: Related ArticlesRisk factors for posttreatment recurrence in patients with intermediate-risk papillary thyroid carcinoma.Am J Surg. 2020 Jan 30;:Authors: Kim Y, Roh JL, Song DE, Cho KJ, Choi SH, Nam SY, Kim SYAbstract BACKGROUND: Papillary thyroid carcinoma (PTC) is generally associated with favorable outcomes; however, intermediate-risk requires further evaluation. We therefore examined...
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Ludwig's angina and steroid use: A narrative review.: Related ArticlesLudwig's angina and steroid use: A narrative review.Am J Otolaryngol. 2020 Feb 01;:102411Authors: Tami A, Othman S, Sudhakar A, McKinnon BJAbstract BACKGROUND: Ludwig's angina, a rapidly progressive cellulitis causing airway obstruction, has traditionally been managed with antibiotics and surgical intervention. More controversial is the use of steroids in the management of patients with this condition. This article summarizes...
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Pathological and therapeutic implications of eosinophil-derived semaphorin 4D in eosinophilic chronic rhinosinusitis.: Related ArticlesPathological and therapeutic implications of eosinophil-derived semaphorin 4D in eosinophilic chronic rhinosinusitis.J Allergy Clin Immunol. 2020 Jan 16;:Authors: Tsuda T, Nishide M, Maeda Y, Hayama Y, Koyama S, Nojima S, Takamatsu H, Okuzaki D, Morita T, Nakatani T, Kato Y, Nakanishi Y, Futami Y, Suga Y, Naito Y, Konaka H, Satoh S, Naito M, Izumi M, Obata S, Nakatani...
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A phase II multicenter randomized controlled trial to compare standard chemoradiation with or without recombinant human endostatin injection (Endostar) therapy for the treatment of locally advanced nasopharyngeal carcinoma: Long-term outcomes update.: Related ArticlesA phase II multicenter randomized controlled trial to compare standard chemoradiation with or without recombinant human endostatin injection (Endostar) therapy for the treatment of locally advanced nasopharyngeal carcinoma: Long-term...
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Pre-treatment tumor size impacts on response to nivolumab in head and neck squamous cell carcinoma.: Related ArticlesPre-treatment tumor size impacts on response to nivolumab in head and neck squamous cell carcinoma.Auris Nasus Larynx. 2020 Feb 05;:Authors: Inoue H, Yokota T, Hamauchi S, Onozawa Y, Kawakami T, Shirasu H, Notsu A, Yasui H, Onitsuka TAbstract OBJECTIVE: Baseline tumor size has been reported to be predictive of immune checkpoint inhibitor efficacy in melanoma and lung cancer....
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Surgical repair of radiation-induced carotid stenosis.: Related ArticlesSurgical repair of radiation-induced carotid stenosis.J Vasc Surg. 2020 Feb 05;:Authors: Renard R, Davaine JM, Couture T, Jayet J, Tresson P, Gaudric J, Chiche L, Koskas FAbstract OBJECTIVE: Carotid endarterectomy and carotid artery stenting are both valid therapeutic options for the treatment of radiation-induced carotid stenosis (RICS). The second has the advantage of being less invasive, although it seems to result...
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Tumor-specific prognosis of mutation-positive patients with head and neck paragangliomas.: Related ArticlesTumor-specific prognosis of mutation-positive patients with head and neck paragangliomas.J Vasc Surg. 2020 Feb 05;:Authors: Sen I, Young WF, Kasperbauer JL, Polonis K, Harmsen WS, Colglazier JJ, DeMartino RR, Oderich GS, Kalra M, Bower TCAbstract BACKGROUND: Genetic testing to identify succinate dehydrogenase (SDH) mutations in patients with head and neck paraganglioma (HNP) has been...
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The impact of peritumoral depapillation in cancers of the tongue.: Related ArticlesThe impact of peritumoral depapillation in cancers of the tongue.Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Feb 05;:Authors: Singh A, Singhavi H, Sathe P, Mair M, Qayyumi B, Shetty R, Bal M, Joshi P, Nair S, Chaturvedi PAbstract OBJECTIVES: We observed that a prominent strip of depapillated mucosa surrounded tongue carcinomas. This study evaluates its correlation with other prognosticating factors. ...
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Comparison of hand-sewn versus modified coupled arterial anastomoses in head and neck reconstruction: a single operator's experience.: Related ArticlesComparison of hand-sewn versus modified coupled arterial anastomoses in head and neck reconstruction: a single operator's experience.Int J Oral Maxillofac Surg. 2020 Feb 05;:Authors: Guo Z, Cui W, Hu M, Yu B, Han B, Li Y, Tang X, Li C, Li LAbstract Microvascular coupler devices have gained wide acceptance as an alternative to the traditional...
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Endonasal endoscopic surgery for pediatric anterior cranial fossa encephaloceles: A systematic review.: Related ArticlesEndonasal endoscopic surgery for pediatric anterior cranial fossa encephaloceles: A systematic review.Int J Pediatr Otorhinolaryngol. 2020 Feb 01;132:109919Authors: Lee JA, Byun YJ, Nguyen SA, Schlosser RJ, Gudis DAAbstract BACKGROUND: Endoscopic endonasal skull base surgery (ESBS) is a well-established management strategy for anterior cranial fossa (ACF) encephaloceles...
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Effect of probiotics in experimental otitis media with effusion.: Related ArticlesEffect of probiotics in experimental otitis media with effusion.Int J Pediatr Otorhinolaryngol. 2020 Feb 01;132:109922Authors: Kaytez SK, Ocal R, Yumusak N, Celi K H, Arslan N, Ibas MAbstract OBJECTIVES: The article's aim was to investigate the effects of probiotics in the experimental otitis media with effusion. MATERIALS AND METHODS: Twenty-four male Wistar albino rats were used. They were divided into...
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Immediate Ansa Cervicalis-to-Recurrent Laryngeal Nerve Anastomosis for the Management of Recurrent Laryngeal Nerve Infiltration by a Differentiated Thyroid Carcinoma.: Related ArticlesImmediate Ansa Cervicalis-to-Recurrent Laryngeal Nerve Anastomosis for the Management of Recurrent Laryngeal Nerve Infiltration by a Differentiated Thyroid Carcinoma.ORL J Otorhinolaryngol Relat Spec. 2020 Feb 07;:1-13Authors: Wang W, Liu F, Zhang C, Li M, Chen S, Gao Y, Chen M, Zheng HAbstract OBJECTIVES: The...
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Drug-Induced Sleep Endoscopy: Evaluation of a Selection Tool for Treatment Modalities for Obstructive Sleep Apnea.: Related ArticlesDrug-Induced Sleep Endoscopy: Evaluation of a Selection Tool for Treatment Modalities for Obstructive Sleep Apnea.Respiration. 2020 Feb 07;:1-7Authors: Vroegop AV, Vanderveken OM, Verbraecken JAAbstract Obstructive sleep apnea (OSA) is a very common disorder with important day and nighttime symptoms and long-term effects on health. Different treatment modalities...
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Tracheostomy Complications in the Emergency Department: A National Analysis of 38,271 Cases.: Related ArticlesTracheostomy Complications in the Emergency Department: A National Analysis of 38,271 Cases.ORL J Otorhinolaryngol Relat Spec. 2020 Feb 07;:1-8Authors: Kligerman MP, Saraswathula A, Sethi RK, Divi VAbstract BACKGROUND: Greater than 100,000 tracheotomies are performed annually in the USA, yet little is known regarding patients who present to the emergency department (ED) with tracheostomy...
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Otorhinolaryngologists nominated for the Nobel Prize 1901-1940.: Related ArticlesOtorhinolaryngologists nominated for the Nobel Prize 1901-1940.Eur Arch Otorhinolaryngol. 2020 Feb 08;:Authors: Hansson N, Drobietz M, Mudry AAbstract PURPOSE: Several scholars with links to ENT have received the Nobel Prize in physiology or medicine. This overview takes into account ENT Nobel nominees, who never received the award. METHODS: Drawing a comparison on the nominations collected in the archive...
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Electrophysiological and inner ear MRI findings in patients with bilateral vestibulopathy.: Related ArticlesElectrophysiological and inner ear MRI findings in patients with bilateral vestibulopathy.Eur Arch Otorhinolaryngol. 2020 Feb 08;:Authors: Eliezer M, Hautefort C, Van Nechel C, Duquesne U, Guichard JP, Herman P, Kania R, Houdart E, Attyé A, Toupet MAbstractPURPOSE: Bilateral vestibulopathy (BV) is an uncommon disorder and the etiology remained idiopathic in most cases. Delayed 3D-FLAIR sequences...
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The diagnostic criteria set forth by Cohen and Friedman include pain, exudates, edema, and granulation tissue of EAC and positive technetium 99 m (Tc99 m) scan.Patients with MOE usually complain of otalgia that is out of proportion and is also worse at night. Other symptoms include conductive deafness, headache, and temporomandibular joint pain.The cardinal signs on examination include woody induration of pinna, preauricular cellulitis, and tender EAC with granulation tissue.https://alsfakia1.blogspot.com/2020/02/skull-base-osteomyelitis-clinical-and.html#Medicine...
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Skull base osteomyelitis: clinical and radiologic analysis of a rare and multifaceted pathological entity.: Related ArticlesSkull base osteomyelitis: clinical and radiologic analysis of a rare and multifaceted pathological entity.Neurosurg Rev. 2020 Feb 08;:Authors: Schreiber A, Ravanelli M, Rampinelli V, Ferrari M, Vural A, Mattavelli D, Mataj E, Mazza V, Zorza I, Bonù ML, Signorini L, Chiari E, Sorrentino T, Doglietto F, Farina D, Maroldi R, Nicolai PAbstractSkull base osteomyelitis (SBO) is a...
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Activation of TLR4 signaling inhibits progression of osteosarcoma by stimulating CD8-positive cytotoxic lymphocytes: AbstractBackgroundOsteosarcoma (OS) is the most common malignant bone tumor and the prognosis of advanced cases is still poor. Recently, there have been several reports suggesting the relationship between innate immunity and OS, but the detailed mechanism is unknown. We demonstrate the relationship between OS and Toll-like receptor 4 (TLR4) which is one of the most important factors...
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Surgery for Gastric Cancer: State of the Art: AbstractSurgery remains the undisputed mainstay in the management of gastric cancer, and advances in chemotherapy and radiation have improved outcomes in patients with resectable disease. A multidisciplinary approach, with active coordination across specialties dealing with management of gastric cancers provides improved quality of care and outcomes. Radical gastrectomy involves complete removal of tumor with adequate margins and appropriate lymph node...
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Hyperoxia During Exercise: Impact on Adenosine Plasma Levels and Hemodynamic Data: IntroductionAdenosine is an ATP derivative that is strongly implicated in the cardiovascular adaptive response to exercise. In this study, we hypothesized that during exercise the hyperemia, commonly observed during exercise in air, was counteracted by the downregulation of the adenosinergic pathway during hyperoxic exposure.MethodsTen healthy volunteers performed two randomized sessions including gas exposure (Medical...
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Bogong Moths Are Well Camouflaged by Effectively Decolourized Wing Scales: Moth wings are densely covered by wing scales that are assumed to specifically function to camouflage nocturnally active species during day time. Generally, moth wing scales are built according to the basic lepidopteran Bauplan, where the upper lamina consists of an array of parallel ridges and the lower lamina is a thin plane. The lower lamina hence acts as a thin film reflector having distinct reflectance spectra that can...
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Sanhua Decoction, a Classic Herbal Prescription, Exerts Neuroprotection Through Regulating Phosphorylated Tau Level and Promoting Adult Endogenous Neurogenesis After Cerebral Ischemia/Reperfusion Injury: Background: Ischemia stroke is the leading cause of death and long-term disability. Sanhua Decoction (SHD), a classic Chinese herbal prescription, has been used for ischemic stroke for about thousands of years. Here, we aim to investigate the neuroprotective effects of SHD on cerebral ischemia/reperfusion...
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A decade of FRAX: how has it changed the management of osteoporosis?: AbstractThe fracture risk assessment tool, FRAX®, was released in 2008 and provides country-specific algorithms for estimating individualized 10-year probability of hip and major osteoporotic fracture (hip, clinical spine, distal forearm, and proximal humerus). Since its release, 71 models have been made available for 66 countries covering more than 80% of the world population. The website receives approximately 3 million visits...
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Recombinant Hv RNASET2 protein induces marked connective tissue remodelling in the invertebrate model Hirudo verbana: AbstractThe RNASET2 ribonuclease, belonging to the highly conserved RH/T2/s RNase gene family, has been recently shown to modulate inflammatory processes in both vertebrates and invertebrates. Indeed, the RNASET2 protein acts as a chemoattractor for macrophages in both in vitro and in vivo experimental settings and its expression significantly increases following bacterial infections....
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Attenuated regenerative properties in human periodontal ligament–derived stem cells of older donor ages with shorter telomere length and lower SSEA4 expression: AbstractPeriodontal ligament (PDL) stem cell properties are critical in the periodontal tissue regeneration for periodontitis. Previously, we have demonstrated that cigarette smoking attenuates PDL-derived stem cell (PDLSC) regenerative properties. Here, we report the findings on the regenerative properties of human PDLSCs with different...
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Performance of a 6D Treatment Chair for Patient Positioning in an Upright Posture for Fixed Ion Beam Lines: Purpose: To evaluate the mechanical accuracy and the robustness of position alignment under x-ray-based image guidance of a treatment chair with six degrees of freedom (6DTC) which was developed for patient treatment in an upright posture at fixed horizontal beam lines in particle (proton, carbon ion, or others) radiotherapy facilities.Method and Material: The positional accuracy including...
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Feasibility of Bioimpedance Analysis to Assess the Outcome of Complex Decongestive Therapy in Cancer Treatment-Related Lymphedema: Background: Cancer treatment-related lymphedema (CTRL) affects patients physically, psychologically and emotionally, and remains a significant quality of life issue among patients with cancer. Reliable methods to measure changes in lymphedema are required for early detection, acute intensive treatment, and long-term management. Here, we evaluated the use of bioimpedance...
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Intracranial Metastases Originating From Pediatric Primary Spinal Cord Glioblastoma Multiforme: A Case Report and Literature Review: Primary spinal cord glioblastoma multiforme (scGBM) is an uncommon entity in pediatrics, and intracranial metastasis originating in spinal cord gliomas is very rare. A 7-year-old female presented with weakness in the limbs, paralysis of the lower limbs and incontinence. The initial MRI of the spinal cord revealed expansion and abnormal signals from T2 to T5. She was...
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Targeting Metabolic Deregulation Landscapes in Breast Cancer Subtypes: Metabolic deregulation is an emergent hallmark of cancer. Altered patterns of metabolic pathways result in exacerbated synthesis of macromolecules, increased proliferation, and resistance to treatment via alteration of drug processing. In addition, molecular heterogeneity creates a barrier to therapeutic options. In breast cancer, this broad variation in molecular metabolism constitutes, simultaneously, a source of prognostic...
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Potential Immune-Related Adverse Events Associated With Monotherapy and Combination Therapy of Ipilimumab, Nivolumab, and Pembrolizumab for Advanced Melanoma: A Systematic Review and Meta-Analysis: Background: The use of ipilimumab, nivolumab, and pembrolizumab as monotherapies or in combination has transformed the management of advanced melanoma even though these drugs are associated with a new profile of immune-related adverse events (irAEs). The incidence of irAEs from clinical trials of these...
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Concordance of Hormone Receptor Status and BRCA1/2 Mutation Among Women With Synchronous Bilateral Breast Cancer: Goals: BRCA1/2 mutations are associated with bilateral breast cancer. The extent of concordance between synchronous bilateral breast cancer (SBBC) tumors with respect to hormone receptor expression and BRCA1/2 mutations is unknown. We investigated the distribution of BRCA1/2 mutations and bilateral estrogen receptor (ER) status in SBBC.Methods: A retrospective analysis was performed on...
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Hypofractionated Radiotherapy Dose Scheme and Application of New Techniques Are Associated to a Lower Incidence of Radiation Pneumonitis in Breast Cancer Patients: Purpose: Radiation pneumonitis (RP) is one of the most severe toxicities experienced by patients with breast cancer after radiotherapy (RT). RT fractionation schemes and techniques for breast cancer have undergone numerous changes over the past decades. This study aimed to investigate the incidence of RP as a function of such changes in...
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From the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine: Cancer drug discovery is an inefficient process, with more than 90% of newly-discovered therapies failing to gain regulatory approval. Patient-derived models of cancer offer a promising new approach to identify new treatments; however, for rare cancers, such as sarcomas, access to patient samples is limited, which precludes...
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Penicilazaphilone C, a New Azaphilone, Induces Apoptosis in Gastric Cancer by Blocking the Notch Signaling Pathway: Penicilazaphilone C (PAC) is a novel azaphilonidal derivative isolated by our group that demonstrates good anticancer activities. Considering that its molecular mechanisms remain largely unknown, here we explore the molecular mechanisms of the anticancer activities of PAC against gastric cancer. The in vitro effects of PAC on cell growth, proliferation, and apoptosis were evaluated...
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Preclinical Models of Malignant Mesothelioma: Rodent models of malignant mesothelioma help facilitate the understanding of the biology of this highly lethal cancer and to develop and test new interventions. Introducing the same genetic lesions as found in human mesothelioma in mice results in tumors that show close resemblance with the human disease counterpart. This includes the extensive inflammatory responses that characterize human malignant mesothelioma. The relatively fast development of mesothelioma...
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Tyrosine Kinase Inhibitor Resistance Increased the Risk of Cerebral Radiation Necrosis After Stereotactic Radiosurgery in Brain Metastases of Non-small-Cell Lung Cancer: A Multi-Institutional Retrospective Case-Control Study: Objective: This study aimed to investigate the relationship between the timing of stereotactic radiosurgery (SRS) intervention and the complications of cerebral radiation necrosis (CRN) in patients with brain metastases of lung adenocarcinoma who received tyrosine kinase inhibitor...
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CDX2: A Prognostic Marker in Metastatic Colorectal Cancer Defining a Better BRAF Mutated and a Worse KRAS Mutated Subgroup: Background: Survival of metastatic colorectal cancer (mCRC) patients has improved, but mainly for trial patients. New predictive and prognostic biomarkers validated in the general mCRC population are needed. Caudal-type homeobox 2 (CDX2) is an intestine-specific transcription factor with potential prognostic and predictive effect, but the importance in mCRC has not been fully...
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Hypofractionated Irradiation Suppressed the Off-Target Mouse Hepatocarcinoma Growth by Inhibiting Myeloid-Derived Suppressor Cell-Mediated Immune Suppression: Background: Stereotactic radiotherapy treats hepatocellular carcinoma (HCC) at different stages effectively and safely. Besides its direct killing of cancer cells, radiotherapy stimulates host immunity against hepatoma. However, the role of myeloid-derived suppressor cells (MDSCs) in on-target and off-target anti-HCC effects induced by hypofractionated...
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Inversion of PM2.5 atmospheric refractivity profile based on AlexNet model from the perspective of electromagnetic wave propagation: AbstractHuman civilization has reached an unprecedented height, but the industrialization of economic development also brings global warming, ozone depletion, acid rain, fresh water resources crisis, energy shortage, and environmental problems. In autumn and winter, haze becomes the usual state in the modern society, and PM2.5 has been becoming an important form of...
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Hematological parameters and hair mercury levels in adolescents from the Colombian Caribbean: AbstractMercury (Hg) is one of the heavy metals of concern for fish-eating populations. This pollutant can be released from many sources and generates diverse toxic effects in humans. The aim of this study was to evaluate hematological parameters and their relationship with total Hg (T-Hg) levels in the hair of adolescents from Tierrabomba, an island close to an industrialized area, and also from San Onofre,...
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Changes of various insecticides during in vitro human digestion: AbstractThis study was performed to determine the effects of in vitro human digestion on the concentrations of five insecticides, namely 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD), 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE), bifenthrin, and fipronil. In vitro models included all the steps of human digestion, i.e., passage through the mouth, stomach, small intestine,...
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Changes in extrapulmonary organs and serum enzyme biomarkers after chronic exposure to Buenos Aires air pollution: AbstractUrban air pollution is a serious environmental problem in developing countries worldwide, and health is a pressing issue in the megacities in Latin America. Buenos Aires is a megacity with an estimated moderate Air Quality Index ranging from 42 to 74 μg/m3. Exposure to Urban Air Particles from Buenos Aires (UAP-BA) induces morphological and physiological respiratory alterations;...
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Changes in extrapulmonary organs and serum enzyme biomarkers after chronic exposure to air pollution
Changes in extrapulmonary organs and serum enzyme biomarkers after chronic exposure to Buenos Aires air pollution: AbstractUrban air pollution is a serious environmental problem in developing countries worldwide, and health is a pressing issue in the megacities in Latin America. Buenos Aires is a megacity with an estimated moderate Air Quality Index ranging from 42 to 74 μg/m3. Exposure to Urban Air Particles from Buenos Aires (UAP-BA) induces morphological and physiological respiratory alterations;...
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Evaluation of self-calibrated non-linear phase-contrast correction in pediatric and congenital cardiovascular magnetic resonance imaging: AbstractBackgroundThe need for background error correction in phase-contrast flow analysis has historically posed a challenge in cardiac magnetic resonance (MR) imaging. While previous studies have shown that phantom correction improves flow measurements, it impedes scanner workflow.ObjectiveTo evaluate the efficacy of self-calibrated non-linear phase-contrast...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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