Treatment of basilar artery stenosis with an Apollo balloon-expandable stent: a single-centre experience with 61 consecutive cases: AbstractStent placement for basilar artery (BA) stenosis remains a technical and clinical challenge. This retrospective study introduces the experience with the Apollo balloon-expandable stent (BES) for patients with symptomatic BA stenosis in a single centre in China. Sixty one patients who had undergone intervention for severe symptomatic BA stenosis between May 2012...
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Elevated Prevalence of Azole-Resistant Aspergillus fumigatus in Urban versus Rural Environments in the United Kingdom: Antimicrobial Agents and Chemotherapy Elevated Prevalence of Azole-Resistant Aspergillus fumigatus in Urban versus Rural Environments in the United Kingdom.Sewell TR1, Zhang Y2, Brackin AP2, Shelton JMG2, Rhodes J2, Fisher MC2Author informationAntimicrobial Agents and Chemotherapy, 23 Aug 2019, 63(9)DOI: 10.1128/AAC.00548-19 PMID: 31235621 PMCID: PMC6709452Free to read This article...
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Music Training, Working Memory, and Neural Oscillations: A Review: This review focuses on reports that link music training to working memory and neural oscillations. Music training is increasingly associated with improvement in working memory, which is strongly related to both localized and distributed patterns of neural oscillations. Importantly, there is a small but growing number of reports of relationships between music training, working memory, and neural oscillations in adults. Taken together,...
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Clinical outcomes following proton therapy for adult craniopharyngioma: a single-institution cohort study: ConclusionsOur data support the safety and efficacy of proton therapy in the treatment of adult craniopharyngioma as part of primary or salvage treatment. We recommend early consideration of radiotherapy.Trial registrationClinical Trials.gov Identifier: NCT03224767. Accessed December 3, 2019 (Source: Journal of Neuro-Oncology)
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Long-term outcomes of multimodality management for parasagittal meningiomas: ConclusionsThis study demonstrated that PMs were a heterogeneous group of tumors with a high proportion of high-grade tumors that often displayed aggressive clinical behaviors. Low-grade PM benefited from radical resection, whereas high-grade de novo PM did not. Adjuvant radiotherapy significantly prolonged OS for high-grade primary PM, but did not impact survival of patients with subtotally resected low-grade tumors. Long-term...
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Brain Sciences, Vol. 10, Pages 126: Streptococcus thermophilus ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice: Brain Sciences, Vol. 10, Pages 126: Streptococcus thermophilus ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in MiceBrain Sciences doi: 10.3390/brainsci10020126Authors: Dargahi Matsoukas Apostolopoulos Probiotic bacteria have beneficial effects to the development...
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Brain Sciences, Vol. 10, Pages 128: Leg Dominance Effects on Postural Control When Performing Challenging Balance Exercises: Brain Sciences, Vol. 10, Pages 128: Leg Dominance Effects on Postural Control When Performing Challenging Balance ExercisesBrain Sciences doi: 10.3390/brainsci10030128Authors: Arunee Promsri Thomas Haid Inge Werner Peter Federolf Leg dominance reflects the preferential use of one leg over another and is typically attributed to asymmetries in the neural circuitry. Detecting...
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Bone Marrow Mesenchymal Stem Cell-Derived Hepatocyte-Like Cell Exosomes Reduce Hepatic Ischemia/Reperfusion Injury by Enhancing Autophagy: Stem Cells and Development, Ahead of Print.
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Safety of Human Adipose Stromal Vascular Fraction Cells Isolated with a Closed System Device in an Immunocompetent Murine Pressure Ulcer Model: Stem Cells and Development, Ahead of Print.
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miR-29a Promotes the Neurite Outgrowth of Rat Neural Stem Cells by Targeting Extracellular Matrix to Repair Brain Injury: Stem Cells and Development, Ahead of Print.
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Stem Cell Therapy in Brain Ischemia: The Role of Mitochondrial Transfer: Stem Cells and Development, Ahead of Print.
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Lack of evidence for allopurinol for the prevention of a first gout attack in asymptomatic hyperuricemia: a systematic review:
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Circulating human microRNA biomarkers of oxalic acid-induced acute kidney injury: AbstractOxalic acid-induced nephrotoxicity and acute kidney injury result from formation of calcium oxalate crystals. Oxalic acid-induced acute kidney injury is a significant problem in many parts of the world. Circulating biomarkers that can accurately and reproducibly detect acute kidney injury are highly desirable. We used a high sensitivity discovery platform to identify signature microRNAs to distinguish healthy...
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Value and limitation of structure-based profilers to characterize developmental and reproductive toxicity potential: AbstractThe uncertainty regarding the safety of chemicals leaching from food packaging triggers attention. In silico models provide solutions for screening of these chemicals, since many are toxicologically uncharacterized. For hazard assessment, information on developmental and reproductive toxicity (DART) is needed. The possibility to apply in silico toxicology to identify and quantify...
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Role of the tumor microenvironment in regulating the anti-metastatic effect of KISS1: AbstractKISS1, a metastasis suppressor gene, has been shown to block metastasis without affecting primary tumor formation. Loss ofKISS1 leads to invasion and metastasis in multiple cancers, which is the leading cause of cancer morbidity and mortality. The discovery ofKISS1 has provided a ray of hope for early clinical diagnosis and for designing effective treatments targeting metastatic cancer. However, this goal...
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The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned?: AbstractObjectivesTo provide an overview of the three major deadly coronaviruses and identify areas for improvement of future preparedness plans, as well as provide a critical assessment of the risk factors and actionable items for stopping their spread, utilizing lessons learned from the first two deadly coronavirus outbreaks, as well as initial reports from the...
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Dairy, soy, and risk of breast cancer: those confounded milks: AbstractBackgroundAssociations between soy, dairy intakes and breast cancer risk are inconsistent. No studies exist with large numbers of dairy consumers and soy consumers to assess mutual confounding.MethodsThe study cohort contains 52 795 North American women, initially free of cancer, followed for 7.9 years (29.7% were Black). Dietary intakes were estimated from food frequency questionnaires and, for 1011 calibration study subjects,...
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Recent developments in strontium-based biocomposites for bone regeneration: AbstractRecent advances in biomaterial designing techniques offer immense support to tailor biomimetic scaffolds and to engineer the microstructure of biomaterials for triggering bone regeneration in challenging bone defects. The current review presents the different categories of recently explored strontium-integrated biomaterials, including calcium silicate, calcium phosphate, bioglasses and polymer-based synthetic implants...
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Impact of multidisciplinary tumor board discussion on palliation of patients with esophageal or gastro-esophageal junction cancer: a population-based study.: Conclusion: Our study shows that MDT discussion of patients with esophageal or GEJ cancer resulted in more patients treated with initial palliative radiotherapy and chemotherapy compared with patients not discussed by the MDT. Moreover, MDT discussion may have a positive effect on survival, highlighting the importance of MDT meetings at all...
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Prognostic impact of PD-L1 in oropharyngeal cancer after primary curative radiotherapy and relation to HPV and tobacco smoking.: Conclusion: PD-L1 expression had no prognostic significance in OPSCC patients treated with primary radiotherapy alone. A substantial proportion of OPSCC tumors show PD-L1 overexpression, especially in HPV p16+ tumors in patients with little or no smoking history. PMID: 32079442 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
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Cryopreservation of primary cultures of mammalian somatic cells in 96-well plates benefits from control of ice nucleation: Publication date: Available online 21 February 2020Source: CryobiologyAuthor(s): Martin I. Daily, Thomas F. Whale, Riitta Partanen, Alexander D. Harrison, Peter Kilbride, Stephen Lamb, G. John Morris, Helen M. Picton, Benjamin J. MurrayAbstractCryopreservation of mammalian cells has, to date, typically been conducted in cryovials, but there are applications where cryopreservation...
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The future of cryoablation: An abscopal effect: Publication date: Available online 22 February 2020Source: CryobiologyAuthor(s): Jibing Chen, Wei Qian, Feng Mu, Lizhi Niu, Duanming Du, Kecheng XuAbstractCryoablation has become a popular modality to treat a variety of malignant tumors in solid organs and soft tissues. In the future, the use of cryoablation should focus on its abscopal effect. The present review discusses the increased immune response triggered by cryoablation alone or by cryoablation...
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Cryopreservation of the Common Carotid Artery of the Rabbit: Optimization of Dimethyl Sulfoxide Concentration and Cooling Rate: Publication date: Available online 24 February 2020Source: CryobiologyAuthor(s): Y.C. Song, D.E. Pegg, C.J. HuntAbstractThis paper describes the continuation of studies that demonstrated the suitability of CP-Tes solution as a medium for the introduction and removal of dimethyl sulfoxide in rabbit common carotid arteries and established the kinetics of cryoprotectant permeation...
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Pallidal Activity in Cervical Dystonia with and Without Head Tremor: AbstractThe relationship between two common movement disorders, dystonia and tremor, is controversial. Both deficits have correlates in the network that includes connections between the cerebellum and the basal ganglia. In order to assess the physiological relationship between tremor and dystonia, we measured the activity of 727 pallidal single-neurons during deep brain stimulation surgery in patients with cervical dystonia without...
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Stain and Label-Free Microscopy Enables Imaging of Extracellular Vesicles: Researchers at the Beckman Institute of the University of Illinois at Urbana–Champaign have developed a method that employs ultrashort laser pulses to visualize extracellular vesicles in tissue samples without using stains or labeling compounds. An increase in the number of these small vesicles is known to be associated with cancer, whereby cancer cells use them to communicate with each other. Therefore, visualizing them microscopically...
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VitalConnect Introduces Remote Arrhythmia Detection Using VitalPatch: In a world where cardiovascular diseases are the leading cause of death (with an estimated 17.9 million annual deaths globally, according to the WHO), the need to accurately and reliably monitor patients following cardiac procedures is ever-growing. This need is highlighted by the frequency of complications that occur following such procedures. For example, approximately 30% of patients experience problems with electrical conduction...
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Pill-Sized Chemical Heater for Point-of-Care Diagnostic Tests: Researchers at the University of Toronto have developed a miniaturized chemical heater that can precisely heat biological samples during diagnostic tests, but does not require electricity or any specialized equipment to work. The low-cost technology is based on the exothermic reaction that occurs when lithium encounters water, and the precise shape of the pill-sized heater dictates the heating profile it can produce. Performing diagnostic...
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Tozuda Head Impact Sensor: Interview with Jessie Garcia, Tozuda CEO and Founder: Tozuda, a company based in Philadelphia, has developed a head impact sensor that can be attached to a sports helmet, such as those worn by football or hockey players, and which will indicate if a dangerous impact has occurred. The sensor undergoes a simple color change if an impact that is powerful enough to cause a concussion occurs. The company has partnered with Protolabs, who were featured in another Medgadget interview...
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Handheld Eye Scanner to Detect Autism Spectrum Disorder: Researchers at Flinders University in Australia have developed a handheld eye scanner that could help to identify children with autism spectrum disorder. The device allows clinicians to obtain light-adapted electroretinograms, which involves detecting electrical signals in the retina. The device could help in diagnosing children with autism much earlier, meaning that they can get appropriate support as soon as possible. Parents who have had...
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Contour Treats Brain Aneurysms Using Single Device: Cerus Endovascular, a firm based in Fremont, California, won the EU's CE Mark for the Contour Neurovascular System, the company's flagship product. Designed to treat intracranial aneurysms, the Contour is a mesh braid that diverts and disrupts blood flow in and out of an aneurysm.The device is positioned at the neck of the aneurysm and doesn't enter deep into the fragile dome of the diseased structure. This helps to prevent accidents and sizing...
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Novalung FDA Cleared to Provide Long-Term Lung Failure Treatment: Critically ill patients with acute respiratory or cardiopulmonary failure who are on long-term mechanical ventilation too often suffer a variety of side effects. These can include ventilator associated lung injury, pneumonia, and diaphragm dysfunction. Moreover, related sedation and lack of movement can aggravate an already difficult situation.To help address these challenges, the FDA has just cleared the Novalung System, a product...
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Tactile Enhancement to Compensate for Loss of Sensation: A variety of medical conditions, including diabetic neuropathy, infections, and injuries, can lead to a reduced ability to feel touch with one's skin. This can be frustrating and uncomfortable, but it can also result in an inability to walk in comfort, notice wounds and injuries, and deal with everyday tasks.Now researchers in China are reporting in journal Applied Physics Reviews on a technology that significantly boosts a person's ability...
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Critical role for iron accumulation in the pathogenesis of fibrotic lung disease: AbstractIncreased iron levels and/or dysregulated iron homeostasis occurs in several lung diseases. Here, the effects of iron accumulation on the pathogenesis of pulmonary fibrosis and associated lung function decline was investigated using a combination of murine models of iron overload and bleomycin‐induced pulmonary fibrosis, primary human lung fibroblasts treated with iron and histological samples from patients...
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Recent advances in the biology of tumour hypoxia with relevance to diagnostic practice and tissue‐based research: AbstractIn this review article, we examine the importance of low levels of oxygen (hypoxia) in cancer biology. We provide a brief description of how mammalian cells sense oxygen. The hypoxia‐inducible factor (HIF) pathway is currently the best characterised oxygen sensing system, but recent work has revealed that mammals also use an oxygen‐sensing system found in plants to regulate the...
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Biology and therapeutic targeting of tumour‐associated macrophages: AbstractMacrophages sustain tumour progression by facilitating angiogenesis, promoting immunosuppression, and enhancing cancer cell invasion and metastasis. They also modulate tumour response to anti‐cancer therapy in pre‐clinical models. This knowledge has motivated the development of agents that target tumour‐associated macrophages (TAMs), some of which have been investigated in early clinical trials. Here, we provide a comprehensive...
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Plasma Membrane Receptors of Tissue Macrophages: Functions and Role in Pathology: AbstractThe cells of the Mononuclear Phagocyte System constitute a dispersed organ, which is distributed throughout the body. Macrophages in different tissues display distinctive mosaic phenotypes as resident and recruited cells of embryonic and bone marrow origin, respectively. They help to maintain homeostasis during development and throughout adult life, yet contribute to the pathogenesis of many disease processes,...
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Lung proliferative lesion‐promoting effects of left pulmonary ligation in A/J female mice: This present study was conducted in an attempt to examine proliferative lesion‐promoting effect in the lung by compensatory lung growth after left pulmonary ligation. To examine a strong proliferative lesion‐promoting effect in the lung, the effects of left pulmonary ligation on lung proliferative lesions induced by 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) were examined for 12 weeks. The number...
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The intercarotid or alar fascia, other cervical fascias, and their adjacent spaces – a plea for clarification of cervical fascia and spaces terminology: The precise description of fascias and spaces on the neck in this manuscript shows an important topography concering regional anaesthetic block techniques and surgical approaches. AbstractDue to varying descriptions and terminology of fascias of the neck, medical advice relying on this basic knowledge is insufficient. Our goal was to provide a precise...
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Juvenile papillomatosis of the breast (Swiss cheese disease) has frequent associations with PIK3CA and/or AKT1 mutations: Publication date: Available online 21 February 2020Source: Human PathologyAuthor(s): Carole Guillet, Markus Rechsteiner, Elisa Bellini, Matthias Choschzick, Linda Moskovszky, Konstantin Dedes, Bärbel Papassotiropoulos, Zsuzsanna VargaABSTRACTJuvenile papillomatosis (JP), the so-called Swiss cheese disease is a rare benign breast disease of young adults. An association (up to 28...
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Riesenzelltumor des Knochens: ZusammenfassungDas histologische Bild des Riesenzelltumors des Knochens ist charakterisiert durch die zahlreichen osteoklastenähnlichen Riesenzellen. Diese sind aber nicht die eigentlichen Tumorzellen, sondern ein reaktives Infiltrat. Die Tumorzellen sind vielmehr mononukleäre mesenchymale Zellen, die sogar eine osteoblastische Liniendifferenzierung erkennen lassen. Die zweite Gruppe unter den mononukleären Zellen sind reaktive CD68-positive Makrophagen. An der Aktivierung...
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Investigation of the Effect of Secreted Factors from Mesenchymal Stem Cells on Disc Cells from Degenerated Discs: Low back pain is experienced by a large number of people in western countries and may be caused and influenced by many different pathologies and psychosocial factors including disc degeneration. Disc degeneration involves the increased expression of proinflammatory cytokines and matrix metalloproteinases (MMPs) in the disc environment, which leads to the loss of extracellular matrix (ECM)...
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Primary Epithelioid Angiosarcoma of the Uterus: A Rare Tumor with Very Aggressive Behavior: Angiosarcoma is a high-grade vascular tumor arising from endothelial cells of blood vessels. It represents less than 1% of the mesenchymal tumors. Uterine angiosarcoma is an extremely rare tumor with less than 25 cases reported in the literature. It usually presents in postmenopausal women as uterine mass and rarely can arise in a leiomyoma. It is included in the group of tumors of aggressive behavior and...
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Potency estimation of sugammadex for the reversal of moderate rocuronium-induced neuromuscular block: a non-randomized dose–response study: AbstractPurposeThere is no report investigating the precise potency of sugammadex for antagonizing various intensities of rocuronium-induced neuromuscular block. The aim of this study was to evaluate the ED95 of reversibility of sugammadex and reveal the safety factor of 2 mg/kg of sugammadex for moderate rocuronium-induced neuromuscular block.MethodsFifteen...
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Comparison of Mill Suss™-guided radial artery catheterization with the long-axis in-plane ultrasound-guided method under general anesthesia: a randomized controlled trial: AbstractContinuous arterial blood pressure measurement is an effective perioperative monitoring method in patients with high-risk comorbidities. Recently, ultrasound guidance has been reported to facilitate radial artery catheterization. A new device, Mill Suss™, has also been developed for visualization of the radial artery and...
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Research articleOpen AccessPublished: 21 February 2020Predictors of 1-year mortality in patients on prolonged mechanical ventilation after surgery in intensive care unit: a multicenter, retrospective cohort studyYueming Sun, Shuangling Li, Shupeng Wang, Chen Li, Gang Li, Jiaxuan Xu, Hongzhi Wang, Fei Liu, Gaiqi Yao, Zhigang Chang, Yalin Liu, Meixia Shang & Dongxin Wang BMC Anesthesiology volume 20, Article number: 44 (2020) Cite this article59 AccessesAbstractObjectivesThe requirement of prolonged...
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Research articleOpen AccessPublished: 21 February 2020Cytotoxicity of amide-linked local anesthetics on melanoma cells via inhibition of Ras and RhoA signaling independent of sodium channel blockadeQinghong Zheng, Xiaohong Peng & Yaqin Zhang BMC Anesthesiology volume 20, Article number: 43 (2020) Cite this article43 Accesses1 AltmetricMetricsdetailsAbstractBackgroundSubstantial clinical and preclinical evidence have indicated the association between amide-linked local anesthesia and the long-term...
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Research articleOpen AccessPublished: 24 February 2020Detrimental Effects of Filling Laryngotracheal Airways To Excessive Pressure (DEFLATE-P): a quality improvement initiativeAshley V. Fritz, Gregory J. Mickus, Michael A. Vega, J. Ross Renew & Sorin J. Brull BMC Anesthesiology volume 20, Article number: 46 (2020) Cite this articleAbstractBackgroundThis quality improvement (QI) project was performed at a single center to determine the incidence of postoperative complications associated with use...
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IL‐1β prevents ILC2 expansion, type 2 cytokine secretion and mucus metaplasia in response to early‐life rhinovirus infection in mice: AbstractBackgroundEarly‐life wheezing‐associated respiratory infection with human rhinovirus (RV) is associated with asthma development. RV infection of six day‐old immature mice causes mucous metaplasia and airway hyperresponsiveness which is associated with the expansion of IL‐13‐producing type 2 innate lymphoid cells (ILC2s) and dependent on IL‐25 and IL‐33. We...
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Orally applied bacterial lysate in infants at risk for atopy does not prevent atopic dermatitis, allergic rhinitis, asthma or allergic sensitization at school age: follow‐up of a randomized trial: AbstractBackgroundThe allergy preventive effects of gut immune modulation by bacterial compounds are still not fully understood.ObjectiveWe sought to evaluate the effect of bacterial lysate applied orally from the second until seventh months of life on the prevalence of allergic diseases at school age.MethodsIn...
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Hard Palate Mucoperiosteal Transplantation for Defects of the Upper Eyelid: A Pilot Study and Evaluation: Purpose: To use hard palate mucoperiosteum to reconstruct the upper eyelid wisely and to evaluate its function and outcome.Methods: In this case series, medial or lateral defects of the upper eyelid were reconstructed with a hard palate mucoperiosteum graft and a bandage contact lens to protect the cornea. Slit-lamp examinations, in vivo confocal microscopy, patient surveys, and pathologic examinations...
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Primitive Myxoid Mesenchymal Tumor of Infancy in the Orbit: A New Location for a Rare Tumor: Primitive myxoid mesenchymal tumor of infancy is a rare subtype of sarcoma. With the advent of relevant immunohistochemical and genetic analysis, it was defined by Alaggio et al. in a 2006 case series. Since then, 25 further cases are described in the literature—arising variably from the neck, chest, scalp, abdomen, back, or limbs. Here it is described for the first time arising in the orbit, confirmed by...
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Autoaugmentation mastopexy using the double-flap technique: AbstractBackgroundBreast drooping usually results from two concomitant factors: breast parenchymal involution, which leads to volume loss, altogether with a progressive laxity of the skin envelope which becomes inelastic and flabby (means so loose). The authors propose a double-flap technique which includes transposition of inferiorly based dermoglandular tissue underneath a superiorly based flap to achieve a central projection and upper...
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Comparison of Palpebral Marginal and Traditional Incision Techniques for Double-Eyelid Surgery: AbstractBackgroundThe palpebral marginal incision technique is a novel method for double-eyelid surgery. However, studies comparing palpebral marginal and traditional incisions are scarce. We aimed to compare the two techniques with respect to post-operative patient satisfaction and complications.MethodsThis retrospective analysis included 422 patients who underwent double-eyelid surgery with either the...
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Morphing as a Selection Tool in the Rhinoplasty Consult: A Cross-Sectional Study: Facial plast SurgDOI: 10.1055/s-0040-1701480Despite the recognized value of morphing in the literature, this preoperative tool has never been studied in the context of selection process in rhinoplasty. The main purpose of this article is to identify the use of morphing as a filter for unsuitable patients, the attrition rate from the initial consultation to surgery, and whether patients' appreciation on morphing influence...
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Surgical Techniques to Improve the Soft Tissue Triangle in Rhinoplasty: A Systematic Review: Facial plast SurgDOI: 10.1055/s-0040-1701520In this systematic review we aim to (1) describe the anatomy and function of the soft tissue triangle, (2) identify the existing rhinoplasty literature that discusses the role of the soft tissue triangle, (3) provide a summary of the outcome measures for soft tissue triangle techniques in rhinoplasty, and (4) demonstrate the need for further research reviewing soft...
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"Minimally Invasive Cortical Bone Collector: A New Tool in Rhinoplasty.": Publication date: Available online 20 February 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Gokhan SERT, Ozan Bitik, Ibrahim VargelAbstractBackground: In rhinoplasty, careful management of the dorsum to achieve a smooth transition from radix to tip is necessary to improve outcomes. Grafts and alloplastic materials were previously used for treatment of dorsal irregularities. Bone dust is one...
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PRO/AH/EDR> African swine fever - Europe (09): Ukraine, domestic, wild boar, update, OIE: African Swine Fever -- UkraineVolyn: event started on 17 Feb 2020. One outbreak (submitted) reported to date (24 Feb 2020). The event is continuing.Total animals affected:Species / Susceptible / Cases / Deaths / Killed and disposed of / SlaughteredWild boar / - / 1 / 1 / 0 / 0--Communicated by:ProMED-mail******[2] Vinnitsa: domestic swineDate: Thu 20 Feb 2020Source: OIE, WAHIS (World Animal Health Information...
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Adults don't need tetanus, diphtheria boosters if fully vaccinated as children: (Oregon Health & Science University) Adults do not need tetanus or diphtheria booster shots if they've already completed their childhood vaccination series against these rare, but debilitating diseases, research published in the journal Clinical Infectious Diseases indicates. The study found no significant difference in disease rates between countries that require adults to receive tetanus and diphtheria booster shots...
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Angelman syndrome: from mouse models to therapy: Publication date: Available online 21 February 2020Source: NeuroscienceAuthor(s): Diana C. Rotaru, Edwin J. Mientjes, Ype ElgersmaAbstractThe UBE3A gene is part of the chromosome 15q11-q13 region that is frequently deleted or duplicated, leading to several neurodevelopmental disorders. Angelman syndrome (AS) is caused by the absence of functional maternally derived UBE3A protein, while the paternal UBE3A gene is present but silenced specifically in...
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Eukaryotic elongation factor 2 kinase (eEF2K) a pharmacological target to regulate protein translation dysfunction in neurological diseases: Publication date: Available online 21 February 2020Source: NeuroscienceAuthor(s): Stefania Beretta, Laura Gritti, Chiara Verpelli, Carlo SalaAbstractTwo major processes tightly regulate protein synthesis, the initiation of mRNA translation and elongation phase that mediates the movement of ribosomes along the mRNA. The elongation phase is a high energy-consuming...
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Clinical Characteristics and Outcomes of invasive Lomentospora prolificans Infections: Analysis of Patients in the FungiScope® Registry: AbstractObjectivesInvasive fungal infections caused by Lomentospora prolificans are associated with very high mortality rates and can be challenging to treat given pan‐drug resistance to available antifungal agents. The objective of this study was to describe the clinical presentation and outcomes in a cohort of patients with invasive L. prolificans infections.MethodsWe...
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Three cases of advanced cutaneous squamous cell carcinoma treated with a combination of carboplatin and epirubicin:
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Stability study of hydromorphone and bupivacaine mixture by HPLC-UV: ObjectivesThe objective of this study was to evaluate the physical and chemical stability of hydromorphone hydrochloride and bupivacaine hydrochloride in concentrations of 15 mg.ml-1 and 10 mg.mL-1 in 0.9% sodium chloride injection. Test samples of hydromorphone/bupivacaine mixtures were stored at 37°C, body temperature encounterd during continuous intrathecal infusion, for 90 days. The solutions were packaged in 20 ml plastic syringes....
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Meropenem, rifampicin and gentamicin combination therapy in a patient with complicated urinary tract infection caused by extreme drug-resistant P. aeruginosa: In this article, we report a case of a 25-year-old male patient who was under follow-up for nephrolithiasis and repeated urological interventions. His last operation was carried out 9 months ago for insertion of a double-J catheter. Pseudomonas aeruginosa, which is susceptible to only colistin treatment, was detected in the urine culture....
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Anticoagulant and antiplatelet combined therapy in patients 75 years and over with atrial fibrillation: a prospective observational study assessing adherence to clinical guidelines: ObjectiveAccording to current guidelines on atrial fibrillation (AF), the addition of an antiplatelet therapy to an anticoagulant for a stable vascular disease does not decrease the ischaemic hazard but increases the risk of bleeding. The aim of the study was to assess compliance of practices with existing clinical guidelines...
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Comparative efficacy and safety of interventions for preventing chemotherapy-induced oral mucositis in adult cancer patients: a systematic review and network meta-analysis: ObjectiveTo examine the comparative efficacy and safety of interventions for preventing chemotherapy-induced oral mucositis (OM) in adult cancer patients.MethodsWe searched PubMed, Embase and the Cochrane Central systematically for the randomised control trials (RCTs) of interventions for preventing OM. Network meta-analysis (NMA)...
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Promoting clinical pharmacy services through advanced medication review in the emergency department: ObjectivesTo determine if an advanced medication review carried out in the emergency department (ED) increases the number of pharmacotherapy recommendations (PR) and the severity of the detected prescribing errors.MethodsWe designed an analytic observational prospective cohort study with preintervention assessment (PRE) and postintervention assessment (POST). In PRE, prescription review was done by...
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Aortic dissection after ramucirumab infusion: A female patient in her seventies affected by a signet-ring cell carcinoma G3pT4N3 (24/29), with lymphovascular invasion, HER2-negative. After completing three cycles of first-line systemic treatment in combination with cisplatin (CDDP) + 5-fluorouracil (5FU), a new systemic therapy line with paclitaxel + Cyramza (ramucirumab) was planned. On the day after the first administration the patient manifested a Standford type A aortic dissection (AD), with...
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Systematic review of stability data pertaining to selected antibiotics used for extended infusions in outpatient parenteral antimicrobial therapy (OPAT) at standard room temperature and in warmer climates: AimTo determine if there are sufficient stability data to confirm appropriate prescribing of antibiotics commonly used in outpatient parenteral antimicrobial therapy (OPAT) in warmer climates.Data sourcesFour databases were systematically searched using the terms 'beta-lactams', or 'antibiotics',...
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Seizures and quinolone antibiotics in children: a systematic review of adverse events: BackgroundQuinolone antibiotics have a broad spectrum of activity including against Gram-negative organisms (especially Pseudomonas), but their use has been associated with the development of seizures. Our objective was to evaluate the association between the administration of quinolones and seizures for three groups of children: those with epilepsy; those with other CNS disorders; and those without any CNS disorder.MethodWe...
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Smallpox bioterrorism: Smallpox bioterrorism: The misuse of smallpox as an agent of bioterrorism. Smallpox was eradicated in 1977. Routine vaccinations stopped in the US in 1972. More than 40% of Americans and many others around the world have not been vaccinated and are vulnerable. Those who were vaccinated only once are also thought vulnerable. Smallpox is contagious It spreads from person to person through the air and kills about 30% of unvaccinated persons. Should smallpox be reintroduced,...
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Walking pneumonia: Walking pneumonia: A lay term used to refer to atypical pneumonia and typically doesn't require bedrest or hospitalization. Pneumonia is an infection of the lung; atypical pneumonia refers to pneumonia caused by certain bacteria, including Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumoniae. Typically, the pneumonia produced by Mycoplasma and Chlamydophila is characterized by mild symptoms. The most common symptoms of pneumonia are chills and fever,...
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Better outcomes for patients with gout: AbstractGout is increasing in prevalence despite effective pharmacotherapies. Barriers to effective management are largely educational deficiencies. Sufferers, usually men, need to understand more about gout, especially that maintaining serum urate below 0.36 mmol/L will eliminate recurrent attacks. Also, of great importance is appreciating that sub-optimal adherence to urate-lowering therapy (ULT) will result in a return of attacks. Prescribers also need to...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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