If the vocal cords are visible:Insert the introducer guide;Feel palpable vibrations (or clicks);Insert the endotracheal tube over the guide (without removing the laryngoscope);Rotate the endotracheal tube 90° clockwise before passing by vocal cords (keeping the bevel of the tube posteriorly directed eases its positioning and prevents arytenoid injury);Remove the guide, while maintaining the endotracheal tube positioned;Confirm proper endotracheal tube position.If the vocal cords are NOT visible:Insert...
Wed Jan 15, 2020 12:17
Environmental Research International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case ReportIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case Report International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020535 Authors: Abdulmalek Alsharidah Yahya Mahli Nayef Alshabyli Mohammed Alsuhaibani Basidiobolomycosis is...
Wed Jan 15, 2020 10:43
1a6u0b-88krq.html5 ways to connect with Ear, Nose & Throat Journal.eml 2akvsq-nlr70.htmlAnesthesiology Online First.eml 3a1hqh-p5qum.htmlAsian Pac J Trop Biomed - New issue online.eml 4a11r6-gh28h.htmlCancer Research_ January Table of Contents Alert.eml 5ahzkq-fi4ic.htmlClinical Infectious Diseases Advance articles.eml 6afh6m-5rebe.htmlEarly View Alert_ Head & Neck.eml 7a8lut-zyds3.htmlEarly View Alert_ Immunity, Inflammation and Disease.eml 8avzwt-incpw.htmlEarly View Alert_ International...
09:19
Journal of Cardiovascular Development and DiseaseJCDD, Vol. 7, Pages 4: The Prognostic Importance of TAPSE in Early and in Stable Cardiovascular DiseasesJCDD, Vol. 7, Pages 4: The Prognostic Importance of TAPSE in Early and in Stable Cardiovascular Diseases Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7010004 Authors: Paolo Giovanardi Enrico Tincani Marco Maioli Stefano Tondi The identification of predictors of major cardiovascular events (MACES) represents a big challenge,...
09:08
AntibioticsAntibiotics, Vol. 9, Pages 30: Acknowledgement to Reviewers of Antibiotics in 2019Antibiotics, Vol. 9, Pages 30: Acknowledgement to Reviewers of Antibiotics in 2019 Antibiotics doi: 10.3390/antibiotics9010030 Authors: Antibiotics Editorial OfficeAntibioticsWed Jan 15, 2020 02:00Antibiotics, Vol. 9, Pages 29: Chemical Composition and Antibacterial Activity of Essential Oils from the Algerian Endemic Origanum glandulosum Desf. against Multidrug-Resistant Uropathogenic E. coli IsolatesAntibiotics,...
09:06
Frequency and distribution of polyQ disease intermediate-length repeat alleles in healthy Italian population: AbstractBackgroundHuntington disease (HD) and spinocerebellar ataxia type 1-2-17 (SCA1-2-17) are adult-onset autosomal dominant diseases, caused by triplet repeat expansions in the HTT, ATXN1, ATXN2, and TBP genes. Alleles with a repeat number just below the pathological threshold are associated with reduced penetrance and meiotic instability and are defined as intermediate alleles (IAs).ObjectivesWe...
09:03
Extraluminal Duodenal Gangliocytic Paraganglioma Presenting with Intractable Back Pain in a Patient with End-Stage Renal Disease: References1.Dahl EV, Waugh JM, Dahlin DC. Gastrointestinal ganglioneuromas: brief review with report of a duodenal ganglioneuroma. Am J Pathol. 1957;33(5):953–65.CASPubMedPubMed CentralGoogle Scholar2.Easwar A, Middleton D, Ligato S. Cytological diagnosis of duodenal gangliocytic paraganglioma on ultrasound-guided fine needle aspirate: a case report with review of the...
09:03
Surgical Resection of Multiple Small Bowel Neuroendocrine Tumours Using Intraoperative Fluorescence Angiography with Indocyanine Green Dye: BackgroundNeuroendocrine tumours (NETs) are a heterogeneous group of malignancies with a small, but increasingly incidence. They usually arise sporadically, with the highest incidence being from the fifth decade onward [1, 2].Small bowel is the third most common site of NETs after the lung and rectum, but is the most common site of NETs that develop distant metastases....
09:02
Pyoderma Gangrenosum in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis: AbstractBackgroundPyoderma gangrenosum (PG) is an uncommon but severe extra-intestinal manifestation (EIM) of inflammatory bowel disease (IBD). The incidence and risk factors for PG are disputed.AimsTo assess the incidence of PG and identify factors associated with PG in IBD patients.MethodsA search of electronic databases (Ovid and PubMed) was conducted between 1966 and 2019. Studies that calculated the incidence...
09:01
Mutational Mosaics of Cell-Free DNA from Pancreatic Cyst Fluids: AbstractBackgroundPancreatic cyst fluids (PCFs) enriched in tumor-derived DNA are a potential source of new biomarkers. The study aimed to analyze germinal variants and mutational profiles of cell-free (cf)DNA shed into the cavity of pancreatic cysts.MethodsThe study cohort consisted of 71 patients who underwent endoscopic ultrasound fine-needle aspiration of PCF. Five malignant cysts, 19 intraductal papillary mucinous neoplasms (IPMNs),...
09:01
Polyp Detection Rate Correlates Strongly with Adenoma Detection Rate in Trainee Endoscopists: AbstractBackgroundThe adenoma detection rate (ADR) is a widely accepted quality benchmark for screening colonoscopy but can be burdensome to calculate. Previous studies have shown good correlation between polyp detection rate (PDR) and ADR, but this has not been validated in trainees. Additionally, the correlation between PDR and detection rates for sessile serrated polyps (SSPDR) and advanced neoplasia...
09:01
iASPP-Mediated ROS Inhibition Drives 5-Fu Resistance Dependent on Nrf2 Antioxidative Signaling Pathway in Gastric Adenocarcinoma: AbstractAimsInhibitor for the apoptosis-stimulating protein of p53 (iASPP) has been reported to be correlated with 5-fluorouracil (5-Fu) resistance in renal cell carcinoma. Here, we uncover mechanisms of iASPP-Nrf2-ROS regulation of 5-Fu resistance which are important for the development of alternative treatment strategies for gastric adenocarcinoma treatment.MethodsWe...
09:01
Early Treatment Uptake and Cost Burden of Hepatitis C Therapies Among Newly Diagnosed Hepatitis C Patients with a Particular Focus on HIV Coinfection: AbstractBackgroundDespite the high efficacy and safety associated with direct-acting antivirals (DAAs), access to HCV treatment has been frequently restricted because of the high DAA drug costs.ObjectivesTo (1) compare HCV treatment initiation rates between HCV monoinfected and HCV/HIV coinfected patients before (pre-DAA period) and after (post-DAA...
09:01
Estudio observacional de aleatorización mendeliana | El café protege contra los cálculos biliares sintomáticos en la población generalLa ingesta de café está asociada con un bajo riesgo de enfermedad sintomática por cálculos biliaresIntraMed RSS -2hTiempo del médico empleado en el uso de la historia clínica electrónicaEstudio descriptivo que incluyó datos de aproximadamente 100 millones de encuentros de pacientes con aproximadamente 155.000 médicos durante los encuentros ambulatoriosIntraMed RSS...
08:59
Lichen planus related to transforming growth factor beta inhibitor in a patient with metastatic chondrosarcoma: a case report: AbstractTransforming growth factor beta‐1 (TGF‐β1) is expressed in normal epidermis. TGF‐β1 potently inhibits keratinocyte proliferation and immunomodulatory properties, mainly by suppressing immune responses to self‐antigens. Lichen planus (LP) is a form of dermatitis caused by cell‐mediated immune dysfunction, but the exact pathogenic pathways are unknown, which poses therapeutic...
08:59
CD10 and P63 Expression in a Sarcomatoid Undifferentiated Melanoma: A Cautionary (and Molecularly Annotated) Tale: AbstractUndifferentiated melanoma should be considered in the differential diagnosis of sarcomatoid cutaneous malignancies to ensure that patients receive the correct treatment. Dermatopathologists should recognize the pitfalls of relying too heavily on immunohistochemistry to establish this diagnosis and consider ancillary tests, including single nucleotide polymorphism (SNP) copy number...
08:58
Cutaneous "Fibroma‐Like" Perivascular Epithelioid Cell Tumor (PEComa): a case report and review of literature: AbstractPerivascular epithelioid cell tumors (PEComas) are a group of lesions sharing the common features of co‐expression of melanocytic and myogenic markers, with focal association of the cells with vascular walls. The PEComa group exhibits a wide range of morphologies. A "fibroma‐like" variant of PEComa has been recently described. The case reported herein is that of an infant with tuberous...
08:58
Morphological Characteristic of Melanoma B16 Progression in C57BL/6 Mice with High and Low Resistance to HypoxiaThe features of B16 melanoma progression in male C57BL/6 mice with initially high and low resistance to hypoxia were studied. To assess the resistance to hypoxia, the mice were placed in a low-pressure chamber at a simulated altitude of 10,000 m. One month after testing, B16 melanoma was inoculated to high- and low-resistant animals. In 19 days after melanoma transplantation, the severity...
08:58
Adhesive Hydrogels for Maxillofacial Tissue Regeneration Using Minimally Invasive Procedures: This paper describes an adhesive hyaluronic acid (HA)‐based hydrogel, which may be suitable for use in minimally invasive procedures to repair maxillofacial tissues. To create hydrogels, HA is modified with methacrylate and 3,4‐dihydroxyphenylalanine (Dopa), forming a material that can be applied under aqueous conditions and gelled with visible light. Upon Dopa oxidation, hydrogels adhere to tissues and...
08:57
Improving Quantum Yield of a NIR‐II Dye by Phenylazo Group: A NIR‐II fluorophore and its three derivatives bearing respectively amino, tert‐butyloxycarbonyl amino and phenylazo groups are synthesized. It is found that the phenylazo groups can significantly enhance its quantum yield (QY). The phenylazo‐containing fluorophore is encapsulated in micelles and a QY of ≈3.51% is achieved in aqueous medium, which is among the highest of the reported organic NIR‐II probes. AbstractUnderstanding structure‐fluorescence...
08:57
Synthetic Polymers Provide a Robust Substrate for Functional Neuron Culture: Synthetic polymeric substrates for in vitro neuron culture are identified via a high throughput approach. Polymeric substrates are shown to be superior to the current gold standard laminin, showing high levels of neuron and progenitor cell attachment, with the substrate significantly promoting progenitor cell maturation with remarkably high expression of neuron‐related biomarkers in the absence of serum. AbstractSubstrates...
08:57
Bioinspired Biomaterials with a Brick‐and‐Mortar Microstructure Combining Mechanical and Biological Performance: Advanced silicate‐based bioceramic composites with "brick‐and‐mortar" architecture are shown to possess superior mechanical performances matching with cortical bone, controllable bioactive ions release, and the ability to induce bone integration. AbstractThe fabrication of bone regeneration biomaterials, which simultaneously possess superior mechanical performances and excellent bioactivity,...
08:56
Control of Astrocyte Quiescence and Activation in a Synthetic Brain Hydrogel: This work describes the development of a synthetic brain‐mimicking hydrogel. The human brain is characterized mechanically and proteomically, and a modulus and protein composition characteristic of the human brain is defined. Using this brain‐mimicking hydrogel, astrocyte quiescence and activation is controlled via hydrogel composition or soluble cytokines, not possible in other in vitro systems. AbstractBioengineers have...
08:56
Design and Analysis of Elimination Surveys for Neglected Tropical Diseases: AbstractAs neglected tropical diseases approach elimination status, there is a need to develop efficient sampling strategies for confirmation (or not) that elimination criteria have been met. This is an inherently difficult task because the relative precision of a prevalence estimate deteriorates as prevalence decreases, and classic survey sampling strategies based on random sampling therefore require increasingly large sample...
08:56
Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer: AbstractTumor mutations in the gene encoding estrogen receptor alpha (ESR1) have been identified in metastatic breast cancer patients with endocrine therapy resistance. However, relatively little is known about the occurrence of mutations in the progesterone receptor (PGR) gene in this population. The study objective was to determine the frequency and prognostic significance of tumor PGR mutations for patients...
08:56
Non-Syndromic Cleft Lip with or without Cleft Palate: Genome-Wide Association Study in Europeans Identifies a Suggestive Risk Locus at 16p12.1 and Supports SH3PXD2A as a Clefting Susceptibility GeneGenesLatest additions to Europe PMC2hVariants in Miro1 Cause Alterations of ER-Mitochondria Contact Sites in Fibroblasts from Parkinson's Disease PatientsJournal of Clinical MedicineLatest additions to Europe PMC2hHealth in Preconception, Pregnancy and Postpartum Global Alliance: International Network...
08:55
Novel technique of fixing intracorneal rings segments after migration: A 38-year-old patient with a history of non-progressive keratoconus in the left eye presented to us with an uncorrected visual acuity of 20/400, which improved to 20/60 with pinhole. We planned for intracorneal rings segment in the left eye. Postoperatively uncorrected visual acuity improved to 20/30. The patient presented 2 weeks later with severely decreased vision to 20/100 and migration of intracorneal rings were noted with...
08:55
Volatile anaesthetic for treatment of respiratory failure from status asthmaticus requiring extracorporeal membrane oxygenation: A 37-year-old male smoker with asthma presented with status asthmaticus refractory to terbutaline, intravenous magnesium, continuous bronchodilators, steroids, heliox and theophylline infusion. He was intubated on hospital day 2 and cannulated for veno-venous extracorporeal membrane oxygenation (V-V ECMO) on hospital day 3 for refractory respiratory acidosis secondary to...
08:54
Cyclophosphamide, bortezomib and dexamethasone (CyBorD): a promising regimen for renal light chain deposit disease: Renal light chain deposit disease is a rare disease with rapid progression to renal failure when left untreated. There is no standard treatment available. We present a unique case of renal IgA kappa deposit disease who developed severe decline in renal function within a few months of diagnosis. She was started on a single regimen of cyclophosphamide, bortezomib and dexamethasone (CyBorD)...
08:54
Successful liver transplantation for drug-induced vanishing bile duct syndrome: Drug-induced cholestasis has a wide range of clinical presentations, and in a small number of patients, it can progress to severe ductopenia. A 63-year-old woman was referred to our department with progressive cholestasis and hyperbilirubinaemia following a course of flucloxacillin. Despite the comprehensive laboratory, imaging and genetic investigations, no other cause for the cholestasis was demonstrated. Sequential...
08:54
Rare case of bilateral wrist and foot drop from SLE-related vasculitic polyneuropathy: Systemic lupus erythematosus (SLE) is a heterogeneous, chronic, inflammatory, autoimmune disease characterised by multiorgan involvement and the production of multiple autoantibodies. Neurological manifestations in SLE patients are frequently reported—the prevalence is 37%–90%. We present a unique case where the patient presented with bilateral wrist and foot drop for 4 days, which later led to the diagnosis of...
08:53
Rupture of mitral valve papillary muscle: a rare complication following myocardial infarction: Here we present a rare clinical presentation of papillary muscle rupture in a 55-year-old man who presented to accident and emergency department with chest pain and was diagnosed as having had a non-ST elevation myocardial infarction. During the admission, he developed papillary muscle rupture due to the myocardial infarction resulting in acute mitral regurgitation. This caused significant haemodynamic...
08:53
Terlipressin-induced ischaemic skin necrosis: Terlipressin is a commonly used drug in hepatology practice for the two most serious complications of cirrhosis, that is, acute oesophageal variceal bleed and hepatorenal syndrome. Acute-on-chronic liver failure (ACLF) is a medical emergency and is frequently associated with acute kidney injury (AKI). Two male patients with alcohol-induced ACLF with high MELD (Model for End-Stage Liver Disease) score presented with AKI. Both were treated with terlipressin...
08:53
Patterns of care for patients with non-operable T1-4 N+ M0 non-small cell lung cancer in the US and outcomes with radiation or chemotherapy monotherapiesTreatment of patients with inoperable locally advanced non-small cell lung cancer (NSCLC), defined as lymph node-positive (N+) non-metastatic (M0), has improved tremendously since the first trial comparing radiation monotherapy (RTmono) to placebo [1]. Randomized trials established concurrent chemoradiation (CRT) as the standard of care for non-operable...
08:53
The effect of eHealth-based falls prevention programmes on balance in people aged 65 years and over living in the community: protocol for a systematic review of randomised controlled trials: IntroductionBetween 20% and 28% of community-dwelling older people experience a fall each year. Falls can result in significant personal and socioeconomic costs, and are the leading cause of admission to hospital for an older person in Australia. Exercise interventions that target balance are the most effective...
08:51
Improving the quality of life of patients with breast cancer-related lymphoedema by lymphaticovenous anastomosis (LVA): study protocol of a multicentre randomised controlled trial: IntroductionEarly breast cancer detection and advancements in treatment options have resulted in an increase of breast cancer survivors. An increasing number of women are living with the long-term effects of breast cancer treatment, making the quality of survivorship an increasingly important goal. Breast cancer-related...
08:51
Impact of transforming mental health services for young people in England on patient access, resource use and health: a quasi-experimental study: ObjectiveTo evaluate the impact of child and adolescent mental health services (CAMHS) transformation in South East England on patient access, resource utilisation and health outcomes.DesignIn an observational study, we use difference-in-differences analysis with propensity score matching to analyse routinely collected patient level data.SettingThree CAMHS...
08:51
Point-of-care blood tests during home visits by out-of-hours primary care clinicians; a mixed methods evaluation of a service improvement: ObjectivesWe aimed to evaluate test usage and patient and clinician experience following the introduction of point-of-care (POC) blood tests into a primary care out-of-hours service.DesignA mixed methods service evaluation comprising quantitative records of the clinical contexts of tests taken and qualitative interviews with clinicians. Research permissions and...
08:51
Enhanced recovery following hip and knee arthroplasty: a systematic review of cost-effectiveness evidence: AbstractObjectivesTo assess cost-effectiveness of enhanced recovery pathways following total hip and knee arthroplasties. Secondary objectives were to report on quality of studies and identify research gaps for future work.DesignSystematic review of cost–utility analyses.Data sourcesOvid MEDLINE, Embase, the National Health Service Economic Evaluations Database and EconLit, January 2000 to August...
08:50
Cost-effectiveness of total knee replacement in addition to non-surgical treatment: a 2-year outcome from a randomised trial in secondary care in Denmark: ObjectiveTo assess the 24-month cost-effectiveness of total knee replacement (TKR) plus non-surgical treatment compared with non-surgical treatment with the option of later TKR if needed.Methods100 adults with moderate-to-severe knee osteoarthritis found eligible for TKR by an orthopaedic surgeon in secondary care were randomised to TKR plus 12...
08:50
Oral propranolol for treatment of the subgroups of essential tremor: a systematic review and meta-analysis protocol: IntroductionEssential tremor (ET), a tremor disorder, is one of the most common movement disorders. Only oral drugs (propranolol, primidone, topiramate, etc)are still the first-line treatment recommended by the Food and Drug Administration. Propranolol is thought to potentially reduce upper limb action tremor. However, it has a poor effect on axial tremor symptoms, such as essential...
08:50
Womens leadership in academic medicine: a systematic review of extent, condition and interventions: ObjectivesBecause culture reflects leadership, the making of diverse and inclusive medical schools begins with diversity among leaders. The inclusion of women leaders remains elusive, warranting a systematic exploration of scholarship in this area. We ask: (1) What is the extent of women's leadership in academic medicine? (2) What factors influence women's leadership? (3) What is the impact of leadership...
08:50
Cytokine Profiles in Human Parechovirus Type 3-induced Sepsis-like SyndromeWe aimed to assess the kinetics of the release of proinflammatory cytokines and to clarify clinical usefulness as an indicator of the disease activity in human parechovirus type 3 virus (HPeV3)-induced sepsis-like syndrome. We measured serum levels of neopterin, interleukin (IL)-6 and the soluble forms of tumor necrosis factor (TNF) receptor types I (sTNF-RI) and II (sTNF-RII). Serum samples were obtained from 12 patients...
08:49
Projecting the urban energy demand for Indiana, USA, in 2050 and 2080Abstract Energy use is one of the largest drivers of climate change, but the large share of energy used for space heating and cooling is also driven by climate change. Demand for energy, particularly cooling, is important for long-range infrastructure planning. Urban areas represent a very small proportion of total land, but usually consume the majority of energy. In this work, statistical, top-down approaches are used to model...
08:48
IL-9 blockade attenuates inflammation in a murine model of methicillin-resistant Staphylococcus aureus pneumonia: AbstractMethicillin-resistant Staphylococcus aureus (MRSA) is an important etiology of pneumonia. Interleukin (IL)-9 is a T helper 9 (Th9) cytokine and participates in the pathogenesis of infectious diseases. Here, we investigated the role of IL-9 by using an MRSA pneumonia animal model. The BALB/c mice underwent nasal inhalation with an ST239 MRSA strain to establish the mouse model...
08:47
Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study: Background: Data on Candida bloodstream infections in pediatric patients in Europe are limited. We performed a retrospective multicenter European study of the epidemiology and outcome of neonatal and pediatric candidemia. Material and Methods: All first positive blood cultures from patients ≤ 18 years of age with candidemia were registered. Patients' demographic and clinical characteristics...
08:47
GSE132237 CRISPR-Cas9 screens to identify regulators of differentiation in Toxoplasma gondiiContributors : Benjamin S Waldman ; Dominic Schwarz ; Marc H Wadsworth II ; Jeroen P Saeij ; Alex K Shalek ; Sebastian LouridoSeries Type : OtherOrganism : Toxoplasma gondiiTargeted gRNA screen against putative nucleic-acid binding proteins in a differentiation reporter strain context. By looking for gRNAs enriched in parasites no longer able to activate reporter expression, we can identify genes essential...
08:47
Trace elements, polycyclic aromatic hydrocarbons, mineral composition, and FT-IR characterization of unrefined sea and rock salts: environmental interactionsAbstract Unrefined sea salt originates from seawater, typically by natural evaporation. Being minimally processed, it contains the natural minerals and impurities of seawater. Despite the wide applications of salt for culinary and food preservation purposes, the available composition data is particularly limited. Since seawater often contains...
08:45
GSE132237 CRISPR-Cas9 screens to identify regulators of differentiation in Toxoplasma gondiiContributors : Benjamin S Waldman ; Dominic Schwarz ; Marc H Wadsworth II ; Jeroen P Saeij ; Alex K Shalek ; Sebastian LouridoSeries Type : OtherOrganism : Toxoplasma gondiiTargeted gRNA screen against putative nucleic-acid binding proteins in a differentiation reporter strain context. By looking for gRNAs enriched in parasites no longer able to activate reporter expression, we can identify genes essential...
08:43
Trace elements, polycyclic aromatic hydrocarbons, mineral composition, and FT-IR characterization of unrefined sea and rock salts: environmental interactions: AbstractUnrefined sea salt originates from seawater, typically by natural evaporation. Being minimally processed, it contains the natural minerals and impurities of seawater. Despite the wide applications of salt for culinary and food preservation purposes, the available composition data is particularly limited. Since seawater often contains...
08:43
Insulin resistance is an independent risk factor for early neurological deterioration in non-diabetic patients with acute ischemic stroke: AbstractBackgroundThe role of insulin resistance (IR) in stroke prognosis remains largely unknown. This study aimed to investigate the relationship between IR and the risk of early neurological deterioration (END) in non-diabetic patients with acute ischemic stroke.MethodsThis is a retrospective analysis of non-diabetic patients with acute ischemic stroke enrolled...
08:42
Subthalamic nucleus deep brain stimulation in two siblings with chorea-acanthocytosis: Dear Editor,Chorea-acanthocytosis (ChAc) is a core neuroacanthocytosis syndrome and a rare neurodegenerative disease that principally affects the basal ganglia. It is caused by autosomal recessive mutations of VPS13A. The characteristic clinical features of ChAc include the appearance of acanthocytes in the peripheral blood smear and mixed movement disorders including, dystonia, chorea, and parkinsonism. Some patients...
08:42
Frequency and distribution of polyQ disease intermediate-length repeat alleles in healthy Italian population: AbstractBackgroundHuntington disease (HD) and spinocerebellar ataxia type 1-2-17 (SCA1-2-17) are adult-onset autosomal dominant diseases, caused by triplet repeat expansions in the HTT, ATXN1, ATXN2, and TBP genes. Alleles with a repeat number just below the pathological threshold are associated with reduced penetrance and meiotic instability and are defined as intermediate alleles (IAs).ObjectivesWe...
08:41
Novel mutations in SPEF2 causing different defects between flagella and cilia bridge: the phenotypic link between MMAF and PCD: AbstractSevere asthenozoospermia is a common cause of male infertility. Recent studies have revealed that SPEF2 mutations lead to multiple morphological abnormalities of the sperm flagella (MMAF) without primary ciliary dyskinesia (PCD) symptoms in males, but PCD phenotype was also found in one female individual. Therefore, whether there is a phenotypic continuum ranging...
08:41
Foxn1 and Prkdc genes are important for testis function: evidence from nude and scid adult mice: AbstractMutations in Foxn1 and Prkdc genes lead to nude and severe combined immunodeficiency (scid) phenotypes, respectively. Besides being immunodeficient, previous reports have shown that nude mice have lower gonadotropins and testosterone levels, while scid mice present increased pachytene spermatocyte (PS) apoptosis. Therefore, these specific features make them important experimental models for understanding...
08:40
A20-OVA Nanoparticles Inhibit Allergic Asthma in a Murine Model: AbstractThe skewed T helper (Th) 2 response plays a critical role in the pathogenesis of allergic asthma. Regulatory T (Treg) cells and the regulatory cytokines are required in maintaining the homeostasis in the body. This study aims to determine the effects of a poly(lactic-co-glycolic) acid (PLGA)-ovalbumin (OVA)+A20 (a ubiquitin E3 ligase) nanovaccine on inhibiting allergic asthma in a murine model. In this study, A20 and OVA (a...
08:39
MicroRNA-486-5p Promotes Acute Lung Injury via Inducing Inflammation and Apoptosis by Targeting OTUD7B: Abstract The aim of this article is to study the effect of miR-486-5p in acute lung injury (ALI). MiR-486-5p expression in peripheral blood was determined in ALI patients and healthy volunteers by qRT-PCR. ALI mouse model were reproduced by LPS treatment, and miR-486-5p NC and miRNA-486 inhibitors were injected through trachea. ALI patients' peripheral blood and LPS-induced acute lung injury in...
08:39
PNU-282987 Attenuates Intestinal Epithelial Barrier Dysfunction in LPS-Induced Endotoxemia: AbstractPNU-282987, the α7 acetylcholine receptor(α7nAchR) agonist, has been repeatedly reported to play a key role in anti-inflammatory action of multiple disease. However, little is known about its effect on LPS-induced intestinal epithelial barrier dysfunction. This study investigated the protective effects and mechanisms of PNU-282987 on intestinal epithelial barrier dysfunction in lipopolysaccharide(LPS)-induced...
08:39
Ossiculoplasty for Tympanosclerosis: AbstractPurpose of ReviewThe utility of surgery for tympanosclerosis has been a controversial topic among otologic surgeons for many decades. Knowing the variations in tympanosclerotic involvement, different aspects of surgical technique, and audiologic outcomes data can help inform the discussion of optimal management between surgeon and patient.Recent FindingsTympanosclerosis can involve all structures in the middle ear, and the distribution of that involvement...
08:38
Brief Immunology Review for Targeted Biologic Therapies in Allergic Disease: AbstractPurpose of the ReviewThis article provides a concise overview of important aspects of immunology related to atopic disorders and the key inflammatory components that biologic agents target.Recent FindingsOver 15 years ago, the first biologic agent for an allergic disease gained FDA approval. Since then, additional attention has been given to elucidating the underlying pathways involved in these inflammatory disorders...
08:38
The association between Chinese patients' elevated omentin-1 levels, their clinicopathological features, and the risk of colorectal cancer.: Related ArticlesThe association between Chinese patients' elevated omentin-1 levels, their clinicopathological features, and the risk of colorectal cancer.Int J Clin Exp Pathol. 2019;12(6):2264-2274Authors: Zhao X, Zhang Y, Deng L, Wang Y, Li Y, Chen MAbstract To investigate the association between plasma omentin-1 levels and the risk of colorectal cancer...
08:38
A 67-year-old Man With Recurrent Multifocal Cellulitis: A 67-year-old Caucasian man, an avid traveler with a history of hypertension, depression, and previous morbid obesity treated with bariatric surgery, presented with low-grade fever and recurrent left-ankle painful rash (Figure 1A). The patient noted the first episode 2 months prior to presentation when he presented with a poorly defined painful erythematous patch over his left ankle and leukocytosis. He was treated with cefazolin for suspected...
08:37
Cell adhesion in cancer: Beyond the migration of single cells [Signal Transduction]: Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-extracellular matrix interactions. For instance, normal epithelial cells maintain tissue structure by adhering to each other and to the extracellular matrix. The proteins that mediate these distinct interactions are collectively called cell adhesion molecules and are divided into four major groups: cadherins, integrins, selectins,...
08:34
Estrogen-induced FOS like 1 regulates matrix metalloproteinase expression and the motility of human endometrial/decidual stromal cells [Cell Biology]: The regulation mechanisms involved in matrix metalloproteinase (MMP) expression and the motility of human endometrial/decidual stromal cells (ESCs/DSCs) during decidualization remain unclear. DSCs show a significant increased cell motility and expression of FOS like 1 (FOSL1) and MMP-1, -2, -9 when compared with ESCs, whereas a lack of decidualization...
08:34
The basis for non-canonical ROK family function in the N-acetylmannosamine kinase from the pathogen Staphylococcus aureus [Enzymology]: In environments where glucose is limited, some pathogenic bacteria metabolise host derived sialic acid as a nutrient source. N-Acetylmannosamine kinase (NanK) is the second enzyme of the bacterial sialic acid import and degradation pathway and adds phosphate to N-acetylmannosamine using ATP to prime the molecule for future pathway reactions. Sequence alignments reveal...
08:34
ALS-derived fibroblasts exhibit reduced proliferation rate, cytoplasmic TDP-43 aggregation and a higher susceptibility to DNA damage: AbstractBackgroundDermic fibroblasts have been proposed as a potential genetic-ALS cellular model. This study aimed to explore whether dermic fibroblasts from patients with sporadic-ALS (sALS) recapitulate alterations typical of ALS motor neurons and exhibit abnormal DNA-damage response.MethodsDermic fibroblasts were obtained from eight sALS patients and four control...
08:33
Brain MRI of multiple system atrophy of cerebellar type: a prospective study with implications for diagnosis criteria: AbstractAimThe second consensus statement for the diagnosis of multiple system atrophy type cerebellar (MSA-C) includes pons and middle cerebellar peduncle (MCP) atrophy as MRI features. However, other MRI abnormalities such as MCP hyperintensity, hot cross bun sign (HCB), putaminal hypointensity and hyperintense putaminal rim have been described.ObjectivesTo evaluate, in patients...
08:33
A pooled meta-analysis of GPi and STN deep brain stimulation outcomes for cervical dystonia: AbstractObjectiveTo analyze deep brain stimulation (DBS) outcomes in patients with cervical dystonia (CD), the relationships between motor and disability/pain outcomes, and the differences in outcomes between globus pallidus internus (GPi) and subthalamic nucleus (STN) DBS, and to identify potential outcome predictors.MethodsA systematic literature search identified individual patient data of CD patients...
08:33
Assessing heavy metal pollution by biomonitoring honeybee nectar in Córdoba (Spain): AbstractNectar of honeybee colonies has been used in order to identify heavy metals and establish the benefit of this type of studies as a tool for environmental management. For these goals, samples of nectar were obtained from Apis mellifera hives placed in the city of Córdoba (Spain) and its surroundings. Five stations (each with two hives) were selected and samples were collected from May to July of 2007, 2009...
08:32
Acute ecotoxicity and genotoxicity assessment of two wastewater treatment units: AbstractWater contamination by discharge of untreated or poorly treated wastewater into water bodies is a current issue that may cause harm to humans. Water quality assessment targets general parameters, which often misleads to underestimation of their implication in the environment. Acute and genotoxicity assays using Daphnia magna is a reliable tool for testing deleterious effects of wastewater exposure. This paper...
08:32
Environmentally relevant exposures of male mice to carbendazim and thiram cause persistent genotoxicity in male mice: AbstractCarbendazim and thiram are fungicides used in combination to prevent mold destruction of crops. Studies have demonstrated genotoxicity by these agents, but have not used concentrations below their water solubility limits in drinking water to test for persistence of genotoxicity due to chronic exposure. Ten 8-week old male Swiss-Webster mice were exposed to tap water, or nominal...
08:32
"Modern agriculture" transfers many pesticides to watercourses: a case study of a representative rural catchment of southern Brazil: AbstractThe total cultivated area in Brazil reached to 62 million ha in 2018, with the predominance of genetically modified soybean and corn (36 and 17 million ha, respectively) in no-tillage systems. In 2018, 5.3 × 105 Mg of active ingredient of pesticides was applied in cropfields, representing about 7.3 L of commercial product by habitant. However, the monitoring...
08:31
Plastic floating debris along a summer-winter estuarine environmental gradient in a coastal lagoon: how does plastic debris arrive in a conservation unit?: AbstractImproper management of plastic waste is an important contributor to the pollution in water bodies. However, how floating plastic debris is transported to coastal lagoons and marine conservation units is still poorly understood. This work determined the level of contamination due to floating plastic debris in Acaraí Lagoon by establishing...
08:30
Phosphorus removal from wastewater by waste concrete: influence of P concentration and temperature on the product: AbstractThis study investigated the feature of phosphorus uptake by low-cost waste concrete. Adsorption isotherms, metal dissolution, influence of P concentration and temperature, as well as adsorbent regeneration were investigated. Chemical extraction, SEM, XRD, FTIR, and XPS were employed to determine the products of P sequestration. Results demonstrated that phosphate adsorption fitted...
08:30
Embryo/larval toxicity and transcriptional effects in zebrafish ( Danio rerio ) exposed to endocrine active riverbed sediments: AbstractSediment toxicity plays a fundamental role in the health of inland fish communities; however, the assessment of the hazard potential of contaminated sediments is not a common objective in environmental diagnostics or remediation. This study examined the potential of transcriptional endpoints investigated in zebrafish (Danio rerio) exposed to riverbed sediments in...
08:30
Influence of graphene oxide nanosheets on the cotransport of cu-tetracycline multi-pollutants in saturated porous media: AbstractAntibiotic-heavy metal multi-pollutants are produced by intensive livestock farming and become an increasingly prominent problem. In this study, the transport behavior of tetracycline (TC) and its chelate with copper ions (Cu-TC) in saturated sand column with and without graphene oxide (GO) prefilled was investigated by laboratory breakthrough experiments. The effects of...
08:29
Trace elements, polycyclic aromatic hydrocarbons, mineral composition, and FT-IR characterization of unrefined sea and rock salts: environmental interactions: AbstractUnrefined sea salt originates from seawater, typically by natural evaporation. Being minimally processed, it contains the natural minerals and impurities of seawater. Despite the wide applications of salt for culinary and food preservation purposes, the available composition data is particularly limited. Since seawater often contains...
08:29
Distribution and risk analysis of heavy metals in sediments from the Yangtze River Estuary, China: AbstractSediments core within the Yangtze River Estuary was collected for metal and grain size analysis. The vertical distribution characteristics of eight metals along the core were investigated based on 137Cs and 210Pb radionuclide dating. The sediment was mainly composed of sand and silt. The metals concentrations were Al, 4.67–6.83; Fe, 2.3–3.94; Mn, 0.046–0.07; Cr, 69.5–103; Cu, 14.3–32.1; Zn,...
08:29
If the vocal cords are visible:Insert the introducer guide;Feel palpable vibrations (or clicks);Insert the endotracheal tube over the guide (without removing the laryngoscope);Rotate the endotracheal tube 90° clockwise before passing by vocal cords (keeping the bevel of the tube posteriorly directed eases its positioning and prevents arytenoid injury);Remove the guide, while maintaining the endotracheal tube positioned;Confirm proper endotracheal tube position.If the vocal cords are NOT visible:Insert...
Wed Jan 15, 2020 12:17
- Volume: 99, Number: 1 (January 2020)EditorialHuman Subject Research or Quality Improvement Project?Robert T. SataloffImaging ClinicUnilateral Cricoarytenoid Joint Ankylosis in Rheumatoid ArthritisAbdul-Latif Hamdan, Elie Khalifee, and Ghina BerjawiLaryngoscopic ClinicLaryngeal Cryptococcal InfectionJessica R. Winters, Rodolfo E. Manosalva, and Michele P. MorrisonClinical StudyModified Infrahyoid Myocutaneous Flap for Laryngopharyngeal ReconstructionDanqing Yan, Jian Zhang, and Xiang MinEvaluation...
Wed Jan 15, 2020 10:48
Amateur Music Theatre Singers' Perceptions of their Current Singing Voice FunctionThe primary aim of this study was to investigate amateur music theatre singers (MTS)' perceptions of their current singing voice function according to evaluation of ability to sing easily (EASE) scores while involved in a musical theatre production, to determine if scores were influenced by demographic or voice-related factors and to compare EASE scores of amateur MTS and previously published professional MTS.Resident...
Wed Jan 15, 2020 10:47
Environmental Research International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case ReportIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case Report International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020535 Authors: Abdulmalek Alsharidah Yahya Mahli Nayef Alshabyli Mohammed Alsuhaibani Basidiobolomycosis is...
Wed Jan 15, 2020 10:43
If the vocal cords are visible:Insert the introducer guide;Feel palpable vibrations (or clicks);Insert the endotracheal tube over the guide (without removing the laryngoscope);Rotate the endotracheal tube 90° clockwise before passing by vocal cords (keeping the bevel of the tube posteriorly directed eases its positioning and prevents arytenoid injury);Remove the guide, while maintaining the endotracheal tube positioned;Confirm proper endotracheal tube position.If the vocal cords are NOT visible:Insert...
Wed Jan 15, 2020 12:17
Environmental Research International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case ReportIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case Report International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020535 Authors: Abdulmalek Alsharidah Yahya Mahli Nayef Alshabyli Mohammed Alsuhaibani Basidiobolomycosis is...
Wed Jan 15, 2020 10:43
If the vocal cords are visible:Insert the introducer guide;Feel palpable vibrations (or clicks);Insert the endotracheal tube over the guide (without removing the laryngoscope);Rotate the endotracheal tube 90° clockwise before passing by vocal cords (keeping the bevel of the tube posteriorly directed eases its positioning and prevents arytenoid injury);Remove the guide, while maintaining the endotracheal tube positioned;Confirm proper endotracheal tube position.If the vocal cords are NOT visible:Insert...
Wed Jan 15, 2020 12:17
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